Proteinase and Peptidase Inhibition (eBook, PDF)

Recent Potential Targets for Drug Development
Redaktion: Smith, H. John; Simons, Claire

• Format: PDF

Produktbeschreibung

Cellular proteinases and their physiological role in normal and disease states have been the subject of great interest recently. Proteinase and Peptidase Inhibition presents new reports on a wide range of cellular proteinases whose inhibitors may hold the key to the development of new drugs. It deals with enzyme classes, inhibitor types and regulatory mechanisms governing proteinase activity. Target enzymes are fully described and classified by structural similarity, rather than by pharmacological effects. This is a valuable reference for academic and industrial researchers in medicinal chemistry, drug design and development, pharmacology, biochemistry, and molecular and cell biology.

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 440
• Erscheinungstermin: 28. März 2002
• Englisch
• ISBN-13: 9780203219171
• Artikelnr.: 38173055

Autorenporträt

Smith, H. John; Simons, Claire

Inhaltsangabe

Enzyme Classes and Mechanisms. Regulatory Mechanisms for Proteinase
Activity. Matrix Metalloproteinases (MMPs). Proteasomes. Cathepsins.
Calpain. Human Neutrophil Elastase Inhibitors. Thrombin. Inhibitors of
Factor VIIa, Factor IXa, and Factor Xa as Anticoagulants. The
Urokinase-Type Plasminogen Activator (uPA) System: A New Target for Tumor
Therapy. Proteinases Involved in Amyloid ß-Peptide (Aß) Production and
Clearance. Herpes Virus and Cytomegalovirus Proteinase. Human Rhinovirus 3C
Proteinase Inhibitors. Aminopeptidases. The Hepatitis C Virus NS3
Serine-Type Proteinase. Zinc Metallopeptidases. HIV Aspartate Proteinase:
Resistance to Inhibitors. Proteases of Protozoan Parasites for Proteinase
Activity.