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This comprehensive volume provides the reader valuable insight into the major areas of biomedical nanomaterials, advanced nanomedicine, nanotheragnostics, and cutting-edge nanoscaffolds. The ability to control the structure of materials allows scientists to accomplish what once appeared impossible before the advent of nanotechnology. It is now possible to generate nanoscopic self-assembled and self-destructive robots for effective utilization in therapeutics, diagnostics, and biomedical implants. Nanoscopic therapeutic systems incorporate therapeutic agents, molecular targeting, and diagnostic…mehr
This comprehensive volume provides the reader valuable insight into the major areas of biomedical nanomaterials, advanced nanomedicine, nanotheragnostics, and cutting-edge nanoscaffolds. The ability to control the structure of materials allows scientists to accomplish what once appeared impossible before the advent of nanotechnology. It is now possible to generate nanoscopic self-assembled and self-destructive robots for effective utilization in therapeutics, diagnostics, and biomedical implants. Nanoscopic therapeutic systems incorporate therapeutic agents, molecular targeting, and diagnostic imaging capabilities and they have emerged as the next generation of multifarious nanomedicine to improve the therapeutic outcome including chemo and translational therapy. Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering comprises fifteen chapters authored by senior scientists, and is one of the first books to cover nanotheragnostics, which is the new developmental edge of nanomedicine combining both diagnostic and therapeutic elements at the nano level. This large multidisciplinary reference work has four main parts: biomedical nanomaterials; advanced nanomedicine; nanotheragnostics; and nanoscaffolds technology. This groundbreaking volume also covers: * Multifunctional polymeric nanostructures for therapy and diagnosis * Metalla-assemblies acting as drug carriers * Nanomaterials for management of lung disorders and drug delivery * Responsive polymer-inorganic hybrid nanogels for optical sensing, imaging, and drug delivery * Core/shell nanoparticles for drug delivery and diagnosis * Theranostic nanoparticles for cancer imaging and therapy * Magnetic nanoparticles in tissue regeneration * Core-sheath fibers for regenerative medicine
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Ashutosh Tiwari is an assistant professor of nanobioelectronics at the Biosensors and Bioelectronics Centre, IFM-Linköping University, Editor-in-Chief of Advanced Materials Letters, and a materials chemist. He graduated from the University of Allahabad, India. He has published more than 125 articles and patents as well as authored/edited in the field of materials science and technology. Dr.Tiwari received the 2011 "Innovation in Materials Science Award and Medal" during the International Conference on Chemistry for Mankind: Innovative Ideas in Life Sciences. Atul Tiwari is an associate researcher at the Department of Mechanical Engineering in the University of Hawaii, USA. He received his PhD in Polymer Science and earned the Chartered Chemist and Chartered Scientist status from the Royal Society of Chemistry, UK. His areas of research interest include the development of silicones and graphene materials for various industrial applications. Dr. Tiwari has invented several international patents pending technologies that have been transferred to industries. He has been actively engaged in various fields of polymer science, engineering, and technology and has published more than fifty peer-reviewed journal papers, book chapters, and books related to material science.
Inhaltsangabe
Preface xv Part I: Biomedical nanomaterials 1 Nanoemulsions: Preparation, Stability and Application in Biosciences 1 Thomas Delmas, Nicolas Atrux-Tallau, Mathieu Goutayer, SangHoon Han, Jin Woong Kim, and Jérôme Bibette 1.1 Introduction 2 1.2 Nanoemulsion:A Thermodynamic Definition and Its Practical Implications 5 1.3 Stable Nanoemulsion Formulation 9 1.4 Nanoencapsulation in Lipid Nanoparticles 21 1.5 Interactions between Nanoemulsions and the Biological Medium: Applications in Biosciences 35 1.6 General Conclusion 47 References 48 2 Multifunctional Polymeric Nanostructures for Therapy and Diagnosis 57 Angel Contreras-García and Emilio Bucio 2.1 Introduction 58 2.2 Polymeric-based Core-shell Colloid 61 2.3 Proteins and Peptides 64 2.4 Drug Conjugates and Complexes with Synthetic Polymers 65 2.5 Dendrimers, Vesicles, and Micelles 67 2.6 Smart Nanopolymers 71 2.7 Stimuli Responsive Polymer-metal Nanocomposites 75 2.8 Enzyme-responsive Nanoparticles 78 Acknowledgements 83 References 83 3 Carbon Nanotubes: Nanotoxicity Testing and Bioapplications 97 R. Sharma and S. Kwon 3.1 Introduction 98 3.2 Historical Review of Carbon Nanotube 99 3.3 Carbon Nanotubes (CNTs) and Other Carbon Nanomaterials 100 3.4 Motivation - Combining Nanotechnology and Surface Science with Growing Bioapplications 104 3.5 Cytotoxicity Measurement and Mechanisms of CNT Toxicity 111 3.6 MSCs Differentiation and Proliferation on Different Types of Scaffolds 120 3.7 New Lessons on CNT Nanocomposites 130 3.8 Conclusions 135 Part II: Advanced nanomedicine 4 Discrete Metalla-Assemblies as Drug Delivery Vectors 149 Bruno Therrien 4.1 Introduction 149 4.2 Complex-in-a-Complex Systems 150 4.3 Encapsulation of Pyrenyl-functionalized Derivatives 155 4.4 Exploiting the Enhanced Permeability and Retention Effect 159 4.5 Incorporation of Photosensitizers in Metalla-assemblies 162 4.6 Conclusion 165 Acknowledgments 165 References 166 5 Nanomaterials for Management of Lung Disorders and Drug Delivery 169 Jyothi U. Menon, Aniket S. Wadajkar, Zhiwe iXie, and Kytai T. Nguyen 5.1 Lung Structure and Physiology 170 5.2 Common Lung DiseasesAnd Treatment Methods 171 5.3 Types of Nanoparticles (NPs) 173 5.4 Methods for Pulmonary Delivery 179 5.5 Targeting Mechanisms 184 5.6 TherapeuticAgents Used for Delivery 188 5.7 Applications 191 5.8 Design Considerations of NPs 195 5.9 Current Challenges and Future Outlook 197 6 Nano-Sized Calcium Phosphate (CaP) Carriers for Non-Viral Gene/Drug Delivery 199 Donghyun Lee, Geunseon Ahn and Prashant N. Kumta 6.1 Introduction 200 6.2 Vectors for Gene Delivery 202 6.3 Modulation of Protection and Release Characteristics of Calcium Phosphate Vector 213 6.4 Calcium Phosphate Carriers for Drug Delivery Systems 219 6.5 Variants of Nano-calcium Phosphates: Future Trends of the CaPDelivery Systems 221 Acknowledgements 223 References 223 7 Organics ModifiedMesoporous Silica for Controlled Drug Delivery Systems 233 Jingke Fu, Yang Zhao, Yingchun Zhu and Fang Chen 7.1 Introduction 233 7.2 Controlled Drug Delivery Systems Based on Organics Modified 7.3 Conclusions 258 References 259 Part III: Nanotheragnostics 8 Responsive Polymer-Inorganic Hybrid Nanogels for Optical Sensing, Imaging, and Drug Delivery 263 Weitai Wu and Shuiqin Zhou 8.1 Introduction 264 8.2 Mechanisms of Response 268 8.3 Synthesis of Responsive Polymer-inorganic Hybrid Nanogels 285 8.4 Applications 293 References 306 9 Core/Shell Nanoparticles for Drug Delivery and Diagnosis 315 Hwanbum Lee, Jae Yeon Kim, Eun Hee Lee, Young In Park, Keun Sang Oh, Kwangmeyung Kim, Ick Chan Kwonand Soon Hong Yuk 9.2 Core/Shell NPs from Polymeric Micelles 319 9.3 Phospholipid-based Core/Shell Nanoparticles 325 9.4 Layer-by-Layer-Assembled Core/Shell Nanoparticles 329 9.5 Core/Shell NPs for Diagnosis 330 9.4 Conclusions 331 Acknowledgments 331 References 331 10 Dendrimer Nanoparticles and Their Applications in Biomedicine 339 Arghya Paul, Wei Shao, Tom J. Burdon, Dominique Shum-Tim and Satya Prakash 10.1 Introduction 340 10.2 Dendrimers and Their Characteristics 341 10.3 Biomolecular Interactions of Dendrimer Nanocomplexes 343 10.4 PotentialApplications of Dendrimer in Nanomedicine 347 10.5 Conclusion 353 Acknowledgements 355 Indexing words 355 References 355 11 Theranostic Nanoparticles for Cancer Imaging and Therapy 363 Mami Murakami, Mark J. Ernsting and Shyh-Dar Li 11.1 Introduction 363 11.2 Multifunctional Nanoparticles for Noninvasive 11.3 Multifunctional Nanoparticles for Monitoring Drug Release 375 11.4 Theranostics to Image Therapeutic Response 380 11.5 Conclusion and Future Directions 382 Acknowledgement 383 References 383 Part IV: Nanoscaffolds technology 12 Nanostructure Polymers in Function Generating Substitute and Organ Transplants 389 S.K. Shukla 12.1 Introduction 389 12.2 Important Nanopolymers 391 12.3 MedicalApplications 397 Acknowledgement 411 References 411 13 Electrospun Nanofiberfor Three Dimensional Cell Culture 417 Yashpal Sharma, Ashutosh Tiwari and Hisatoshi Kobayashi 13.1 Introduction 417 13.2 Nanofiber Scaffolds Fabrication Techniques 419 13.3 Parameters of Electrospinning Process 424 13.4 Electrospun Nanofibers for Three-dimensional Cell Culture 426 13.5 Conclusions 429 References 431 14 Magnetic Nanoparticles in Tissue Regeneration 435 Anuj Tripathi, Jose Savio Melo and Stanislaus Francis D'Souza 14.1 Introduction 435 14.2 Magnetic Nanoparticles: Physical Properties 438 14.3 Synthesis of Magnetic Nanoparticles 440 14.4 Design and Structure of Magnetic Nanoparticles 443 14.5 Stability and Functionalization of Magnetic Nanoparticles 445 14.6 Cellular Toxicity of Magnetic Nanoparticles 450 14.7 Tissue EngineeringApplications of Magnetic Nanoparticles 453 14.8 Challenges and Future Prospects 473 Acknowledgement 474 References 474 15 Core-sheath Fibersfor Regenerative Medicine 485 Rajesh Vasita and Fabrizio Gelain 15.1 Introduction 486 15.2 Core-sheath Nanofiber Technology 489 15.3Application of Core-sheath Nanofibers 504 15.4 Conclusions 519 References 519
Preface xv Part I: Biomedical nanomaterials 1 Nanoemulsions: Preparation, Stability and Application in Biosciences 1 Thomas Delmas, Nicolas Atrux-Tallau, Mathieu Goutayer, SangHoon Han, Jin Woong Kim, and Jérôme Bibette 1.1 Introduction 2 1.2 Nanoemulsion:A Thermodynamic Definition and Its Practical Implications 5 1.3 Stable Nanoemulsion Formulation 9 1.4 Nanoencapsulation in Lipid Nanoparticles 21 1.5 Interactions between Nanoemulsions and the Biological Medium: Applications in Biosciences 35 1.6 General Conclusion 47 References 48 2 Multifunctional Polymeric Nanostructures for Therapy and Diagnosis 57 Angel Contreras-García and Emilio Bucio 2.1 Introduction 58 2.2 Polymeric-based Core-shell Colloid 61 2.3 Proteins and Peptides 64 2.4 Drug Conjugates and Complexes with Synthetic Polymers 65 2.5 Dendrimers, Vesicles, and Micelles 67 2.6 Smart Nanopolymers 71 2.7 Stimuli Responsive Polymer-metal Nanocomposites 75 2.8 Enzyme-responsive Nanoparticles 78 Acknowledgements 83 References 83 3 Carbon Nanotubes: Nanotoxicity Testing and Bioapplications 97 R. Sharma and S. Kwon 3.1 Introduction 98 3.2 Historical Review of Carbon Nanotube 99 3.3 Carbon Nanotubes (CNTs) and Other Carbon Nanomaterials 100 3.4 Motivation - Combining Nanotechnology and Surface Science with Growing Bioapplications 104 3.5 Cytotoxicity Measurement and Mechanisms of CNT Toxicity 111 3.6 MSCs Differentiation and Proliferation on Different Types of Scaffolds 120 3.7 New Lessons on CNT Nanocomposites 130 3.8 Conclusions 135 Part II: Advanced nanomedicine 4 Discrete Metalla-Assemblies as Drug Delivery Vectors 149 Bruno Therrien 4.1 Introduction 149 4.2 Complex-in-a-Complex Systems 150 4.3 Encapsulation of Pyrenyl-functionalized Derivatives 155 4.4 Exploiting the Enhanced Permeability and Retention Effect 159 4.5 Incorporation of Photosensitizers in Metalla-assemblies 162 4.6 Conclusion 165 Acknowledgments 165 References 166 5 Nanomaterials for Management of Lung Disorders and Drug Delivery 169 Jyothi U. Menon, Aniket S. Wadajkar, Zhiwe iXie, and Kytai T. Nguyen 5.1 Lung Structure and Physiology 170 5.2 Common Lung DiseasesAnd Treatment Methods 171 5.3 Types of Nanoparticles (NPs) 173 5.4 Methods for Pulmonary Delivery 179 5.5 Targeting Mechanisms 184 5.6 TherapeuticAgents Used for Delivery 188 5.7 Applications 191 5.8 Design Considerations of NPs 195 5.9 Current Challenges and Future Outlook 197 6 Nano-Sized Calcium Phosphate (CaP) Carriers for Non-Viral Gene/Drug Delivery 199 Donghyun Lee, Geunseon Ahn and Prashant N. Kumta 6.1 Introduction 200 6.2 Vectors for Gene Delivery 202 6.3 Modulation of Protection and Release Characteristics of Calcium Phosphate Vector 213 6.4 Calcium Phosphate Carriers for Drug Delivery Systems 219 6.5 Variants of Nano-calcium Phosphates: Future Trends of the CaPDelivery Systems 221 Acknowledgements 223 References 223 7 Organics ModifiedMesoporous Silica for Controlled Drug Delivery Systems 233 Jingke Fu, Yang Zhao, Yingchun Zhu and Fang Chen 7.1 Introduction 233 7.2 Controlled Drug Delivery Systems Based on Organics Modified 7.3 Conclusions 258 References 259 Part III: Nanotheragnostics 8 Responsive Polymer-Inorganic Hybrid Nanogels for Optical Sensing, Imaging, and Drug Delivery 263 Weitai Wu and Shuiqin Zhou 8.1 Introduction 264 8.2 Mechanisms of Response 268 8.3 Synthesis of Responsive Polymer-inorganic Hybrid Nanogels 285 8.4 Applications 293 References 306 9 Core/Shell Nanoparticles for Drug Delivery and Diagnosis 315 Hwanbum Lee, Jae Yeon Kim, Eun Hee Lee, Young In Park, Keun Sang Oh, Kwangmeyung Kim, Ick Chan Kwonand Soon Hong Yuk 9.2 Core/Shell NPs from Polymeric Micelles 319 9.3 Phospholipid-based Core/Shell Nanoparticles 325 9.4 Layer-by-Layer-Assembled Core/Shell Nanoparticles 329 9.5 Core/Shell NPs for Diagnosis 330 9.4 Conclusions 331 Acknowledgments 331 References 331 10 Dendrimer Nanoparticles and Their Applications in Biomedicine 339 Arghya Paul, Wei Shao, Tom J. Burdon, Dominique Shum-Tim and Satya Prakash 10.1 Introduction 340 10.2 Dendrimers and Their Characteristics 341 10.3 Biomolecular Interactions of Dendrimer Nanocomplexes 343 10.4 PotentialApplications of Dendrimer in Nanomedicine 347 10.5 Conclusion 353 Acknowledgements 355 Indexing words 355 References 355 11 Theranostic Nanoparticles for Cancer Imaging and Therapy 363 Mami Murakami, Mark J. Ernsting and Shyh-Dar Li 11.1 Introduction 363 11.2 Multifunctional Nanoparticles for Noninvasive 11.3 Multifunctional Nanoparticles for Monitoring Drug Release 375 11.4 Theranostics to Image Therapeutic Response 380 11.5 Conclusion and Future Directions 382 Acknowledgement 383 References 383 Part IV: Nanoscaffolds technology 12 Nanostructure Polymers in Function Generating Substitute and Organ Transplants 389 S.K. Shukla 12.1 Introduction 389 12.2 Important Nanopolymers 391 12.3 MedicalApplications 397 Acknowledgement 411 References 411 13 Electrospun Nanofiberfor Three Dimensional Cell Culture 417 Yashpal Sharma, Ashutosh Tiwari and Hisatoshi Kobayashi 13.1 Introduction 417 13.2 Nanofiber Scaffolds Fabrication Techniques 419 13.3 Parameters of Electrospinning Process 424 13.4 Electrospun Nanofibers for Three-dimensional Cell Culture 426 13.5 Conclusions 429 References 431 14 Magnetic Nanoparticles in Tissue Regeneration 435 Anuj Tripathi, Jose Savio Melo and Stanislaus Francis D'Souza 14.1 Introduction 435 14.2 Magnetic Nanoparticles: Physical Properties 438 14.3 Synthesis of Magnetic Nanoparticles 440 14.4 Design and Structure of Magnetic Nanoparticles 443 14.5 Stability and Functionalization of Magnetic Nanoparticles 445 14.6 Cellular Toxicity of Magnetic Nanoparticles 450 14.7 Tissue EngineeringApplications of Magnetic Nanoparticles 453 14.8 Challenges and Future Prospects 473 Acknowledgement 474 References 474 15 Core-sheath Fibersfor Regenerative Medicine 485 Rajesh Vasita and Fabrizio Gelain 15.1 Introduction 486 15.2 Core-sheath Nanofiber Technology 489 15.3Application of Core-sheath Nanofibers 504 15.4 Conclusions 519 References 519
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