Micro and Nanotechnologies in Engineering Stem Cells and Tissues (eBook, PDF)

Redaktion: Ramalingam, Murugan; Khademhosseini, Ali; Ramakrishna, Seeram; Jabbari, Esmaiel

• Format: PDF

Produktbeschreibung

A cutting-edge look at the application of micro and nanotechnologies in regenerative medicine The area at the interface of micro/nanotechnology and stem cells/tissue engineering has seen an explosion of activity in recent years. This book provides a much-needed overview of these exciting developments, covering all aspects of micro and nanotechnologies, from the fundamental principles to the latest research to applications in regenerative medicine. Written and edited by the top researchers in the field, Micro and Nanotechnologies in Engineering Stem Cells and Tissues describes advances in material systems along with current techniques available for cell, tissue, and organ studies. Readers will gain tremendous insight into the state of the art of stem cells and tissue engineering, and learn how to use the technology in their own research or clinical trials. Coverage includes: * Technologies for controlling or regulating stem cell and tissue growth * Various engineering approaches for stem cell, vascular tissue, and bone regeneration * The design and processing of biocompatible polymers and other biomaterials * Characterization of the interactions between cells and biomaterials Unrivaled among books of this kind, Micro and Nanotechnologies in Engineering Stem Cells and Tissues is the ultimate forward-looking reference for researchers in numerous disciplines, from engineering and materials science to biomedicine, and for anyone wishing to understand the trends in this transformative field.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 328
• Erscheinungstermin: 7. Mai 2013
• Englisch
• ISBN-13: 9781118574973
• Artikelnr.: 38401849

Autorenporträt

MURUGAN RAMALINGAM, PhD, is Associate Professor in the Centre for Stem Cell Research (a unit of Institute for Stem Cell Biology and Regenerative Medicine, Bengaluru) at the Christian Medical College, Vellore, India. He is well known for his pioneering work on gradient biomaterials, stem cell engineering, and soft-to-hard interface tissue engineering. ESMAIEL JABBARI, PhD, is Associate Professor of Chemical and Biomedical Engineering and Adjunct Professor of Orthopedic Surgery at the University of South Carolina. An internationally known researcher, he has published extensively on biomaterials, drug delivery, and tissue engineering. SEERAM RAMAKRISHNA, PhD, is Professor of Mechanical Engineering and Bioengineering at the National University of Singapore. He is well known for his pioneering work on electrospinning of nanofibers. ALI KHADEMHOSSEINI, PhD, is Associate Professor at the Harvard-MIT Division of Health Sciences and Technology, Brigham and Women's Hospital, and Harvard Medical School.

Inhaltsangabe

Preface xiii Contributors xv 1 Stem Cells and Nanotechnology in Tissue Engineering and Regenerative Medicine 1 1.1 A Brief History of Tissue Engineering and Regenerative Medicine
1 1.2 Introduction to Stem Cells
3 1.3 Tissue Engineering and Regenerative Medicine Strategies
5 1.4 Nanotechnology in Regenerative Medicine and Tissue Engineering
8 1.5 Conclusions
19 2 Nanofiber Technology for Controlling Stem Cell Functions and Tissue Engineering 27 2.1 Introduction
27 2.2 Fabrication of Nanofibrous Scaffolds by Electrospinning
30 2.3 Stem Cells: Type
Origin
and Functionality
32 2.4 Stem Cell-Nanofiber Interactions in Regenerative Medicine and Tissue Engineering
35 2.5 Conclusions
44 3 Micro- and Nanoengineering Approaches to Developing Gradient Biomaterials Suitable for Interface Tissue Engineering 52 3.1 Introduction
52 3.2 Classification of Gradient Biomaterials
54 3.3 Micro- and Nanoengineering Techniques for Fabricating Gradient Biomaterials
59 3.4 Conclusions
70 4 Microengineered Polymer- and Ceramic-Based Biomaterial Scaffolds: A Topical Review on Design
Processing
and Biocompatibility Properties 80 4.1 Introduction
80 4.2 Dense Hydroxyapatite Versus Porous Hydroxyapatite Scaffold
85 4.3 Property Requirement of Porous Scaffold
86 4.4 Design Criteria and Critical Issues with Porous Scaffolds for Bone Tissue Engineering
88 4.5 An Exculpation of Porous Scaffolds
90 4.6 Overview of Various Processing Techniques of Porous Scaffold
92 4.7 Overview of Physicomechanical Properties Evaluation of Porous Scaffold
95 4.8 Overview of Biocompatibility Properties: Evaluation of Porous Scaffolds
104 4.9 Outstanding Issues
107 4.10 Conclusions
109 5 Synthetic Enroutes to Engineer Electrospun Scaffolds for Stem Cells and Tissue Regeneration 119 5.1 Introduction
119 5.2 Synthetic Enroutes
125 5.3 Novel Nanofibrous Strategies for Stem Cell Regeneration and Differentiation
131 5.4 Conclusions
135 6 Integrating Top-Down and Bottom-Up Scaffolding Tissue Engineering Approach for Bone Regeneration 142 6.1 Introduction
142 6.2 Clinic Needs in Bone Regeneration Fields
143 6.3 Bone Regeneration Strategies and Techniques
144 6.4 Future Direction and Concluding Remarks
151 7 Characterization of the Adhesive Interactions Between Cells and Biomaterials 159 7.1 Introduction
159 7.2 Adhesion Receptors in Native Tissue
160 7.3 Optimization of Cellular Adhesion Through Biomaterial Modification
166 7.4 Measurement of Cell Adhesion
170 7.5 Conclusions
174 8 Microfluidic Formation of Cell-Laden Hydrogel Modules for Tissue Engineering 183 8.1 Introduction
183 8.2 Cell-Laden Hydrogel Modules
184 8.3 Cell Assay Systems Using Microfluidic Devices
189 8.4 Implantable Applications
191 8.5 Tissue Engineering
194 8.6 Summary
198 9 Micro- and Nanospheres for Tissue Engineering 202 9.1 Introduction
202 9.2 Materials Classification of Micro- and Nanospheres
204 9.3 Applications of Micro- and Nanospheres in Tissue Engineering
205 9.4 Conclusions
212 10 Micro- and Nanotechnologies to Engineer Bone Regeneration 220 10.1 Introduction
220 10.2 Nano-Hydroxyapatite Reinforced Scaffolds
221 10.3 Biodegradable Polymeric Scaffolds and Nanocomposites
225 10.4 Silk Fibers and Scaffolds
227 10.5 Summary
231 11 Micro- and Nanotechnology for Vascular Tissue Engineering 236 11.1 Introduction
236 11.2 Conventional Vascular Grafts
237 11.3 Tissue-Engineered Vascular Grafts
237 11.4 Micro- and Nanotopography in Vascular Tissue Engineering
238 11.5 Micro- and Nanofibrous Scaffolds in Vascular Tissue Engineering
241 11.6 Microvascular Tissue Engineering
246 11.7 Conclusions
253 12 Application of Stem Cells in Ischemic Heart Disease 261 12.1 Introduction
261 12.2 Adult Skeletal Myoblast Cells
267 12.3 Adult Bone Marrow-Derived Stem Cells
269 12.4 Type of Stem Cells Used to Treat Cardiac Diseases
273 12.5 Application
277 12.6 Other Developing Technologies in Cell Engineering
282 Acknowledgments
293 References
293 Index 303