Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering
Ed.:Tiwari, Ashutosh and Tiwari Atul
Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering
Ed.:Tiwari, Ashutosh and Tiwari Atul
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Nanoscopic therapeutic systems incorporate therapeutic agents, molecular targeting and diagnostic imaging capabilities and are emerging as the next generation of multifarious nanomedicine to improve the therapeutic outcome including chemo and translational therapy. This reference work is one of the first to cover Nanotheragnostics which is the new edge of nanomedicine combining both diagnostic and therapeutic elements at nano level. This large multidisciplinary reference work is has four main parts: Biocompatible Nanomaterials; Nanomedicine: Drug Gene and Cell Delivery; Multi-functional…mehr
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Nanoscopic therapeutic systems incorporate therapeutic agents, molecular targeting and diagnostic imaging capabilities and are emerging as the next generation of multifarious nanomedicine to improve the therapeutic outcome including chemo and translational therapy. This reference work is one of the first to cover Nanotheragnostics which is the new edge of nanomedicine combining both diagnostic and therapeutic elements at nano level.
This large multidisciplinary reference work is has four main parts: Biocompatible Nanomaterials; Nanomedicine: Drug Gene and Cell Delivery; Multi-functional Nanocarrier: Diagnosis, Imaging and Treatment; Tissue Engineering/Regenerative Medicine.
This large multidisciplinary reference work is has four main parts: Biocompatible Nanomaterials; Nanomedicine: Drug Gene and Cell Delivery; Multi-functional Nanocarrier: Diagnosis, Imaging and Treatment; Tissue Engineering/Regenerative Medicine.
Produktdetails
- Produktdetails
- Verlag: Wiley & Sons
- 1. Auflage
- Seitenzahl: 576
- Erscheinungstermin: 18. Februar 2013
- Englisch
- Abmessung: 236mm x 163mm x 33mm
- Gewicht: 930g
- ISBN-13: 9781118290323
- ISBN-10: 1118290321
- Artikelnr.: 36901190
- Verlag: Wiley & Sons
- 1. Auflage
- Seitenzahl: 576
- Erscheinungstermin: 18. Februar 2013
- Englisch
- Abmessung: 236mm x 163mm x 33mm
- Gewicht: 930g
- ISBN-13: 9781118290323
- ISBN-10: 1118290321
- Artikelnr.: 36901190
Ashutosh Tiwari is an assistant professor of nanobioelectronics at the Biosensors and Bioelectronics Centre, IFM-Linköping University, Editor-in-Chief of Advanced Materials Letters, and a materials chemist. He graduated from the University of Allahabad, India. He has published more than 125 articles and patents as well as authored/edited in the field of materials science and technology. Dr.Tiwari received the 2011 "Innovation in Materials Science Award and Medal" during the International Conference on Chemistry for Mankind: Innovative Ideas in Life Sciences. Atul Tiwari is an associate researcher at the Department of Mechanical Engineering in the University of Hawaii, USA. He received his PhD in Polymer Science and earned the Chartered Chemist and Chartered Scientist status from the Royal Society of Chemistry, UK. His areas of research interest include the development of silicones and graphene materials for various industrial applications. Dr. Tiwari has invented several international patents pending technologies that have been transferred to industries. He has been actively engaged in various fields of polymer science, engineering, and technology and has published more than fifty peer-reviewed journal papers, book chapters, and books related to material science.
Preface xv Part I: Biomedical nanomaterials 1 Nanoemulsions: Preparation,
Stability and Application in Biosciences 1 Thomas Delmas, Nicolas
Atrux-Tallau, Mathieu Goutayer, SangHoon Han, Jin Woong Kim, and Jérôme
Bibette 1.1 Introduction 2 1.2 Nanoemulsion:A Thermodynamic Definition and
Its Practical Implications 5 1.3 Stable Nanoemulsion Formulation 9 1.4
Nanoencapsulation in Lipid Nanoparticles 21 1.5 Interactions between
Nanoemulsions and the Biological Medium: Applications in Biosciences 35 1.6
General Conclusion 47 References 48 2 Multifunctional Polymeric
Nanostructures for Therapy and Diagnosis 57 Angel Contreras-García and
Emilio Bucio 2.1 Introduction 58 2.2 Polymeric-based Core-shell Colloid 61
2.3 Proteins and Peptides 64 2.4 Drug Conjugates and Complexes with
Synthetic Polymers 65 2.5 Dendrimers, Vesicles, and Micelles 67 2.6 Smart
Nanopolymers 71 2.7 Stimuli Responsive Polymer-metal Nanocomposites 75 2.8
Enzyme-responsive Nanoparticles 78 Acknowledgements 83 References 83 3
Carbon Nanotubes: Nanotoxicity Testing and Bioapplications 97 R. Sharma and
S. Kwon 3.1 Introduction 98 3.2 Historical Review of Carbon Nanotube 99 3.3
Carbon Nanotubes (CNTs) and Other Carbon Nanomaterials 100 3.4 Motivation -
Combining Nanotechnology and Surface Science with Growing Bioapplications
104 3.5 Cytotoxicity Measurement and Mechanisms of CNT Toxicity 111 3.6
MSCs Differentiation and Proliferation on Different Types of Scaffolds 120
3.7 New Lessons on CNT Nanocomposites 130 3.8 Conclusions 135 Part II:
Advanced nanomedicine 4 Discrete Metalla-Assemblies as Drug Delivery
Vectors 149 Bruno Therrien 4.1 Introduction 149 4.2 Complex-in-a-Complex
Systems 150 4.3 Encapsulation of Pyrenyl-functionalized Derivatives 155 4.4
Exploiting the Enhanced Permeability and Retention Effect 159 4.5
Incorporation of Photosensitizers in Metalla-assemblies 162 4.6 Conclusion
165 Acknowledgments 165 References 166 5 Nanomaterials for Management of
Lung Disorders and Drug Delivery 169 Jyothi U. Menon, Aniket S. Wadajkar,
Zhiwe iXie, and Kytai T. Nguyen 5.1 Lung Structure and Physiology 170 5.2
Common Lung DiseasesAnd Treatment Methods 171 5.3 Types of Nanoparticles
(NPs) 173 5.4 Methods for Pulmonary Delivery 179 5.5 Targeting Mechanisms
184 5.6 TherapeuticAgents Used for Delivery 188 5.7 Applications 191 5.8
Design Considerations of NPs 195 5.9 Current Challenges and Future Outlook
197 6 Nano-Sized Calcium Phosphate (CaP) Carriers for Non-Viral Gene/Drug
Delivery 199 Donghyun Lee, Geunseon Ahn and Prashant N. Kumta 6.1
Introduction 200 6.2 Vectors for Gene Delivery 202 6.3 Modulation of
Protection and Release Characteristics of Calcium Phosphate Vector 213 6.4
Calcium Phosphate Carriers for Drug Delivery Systems 219 6.5 Variants of
Nano-calcium Phosphates: Future Trends of the CaPDelivery Systems 221
Acknowledgements 223 References 223 7 Organics ModifiedMesoporous Silica
for Controlled Drug Delivery Systems 233 Jingke Fu, Yang Zhao, Yingchun Zhu
and Fang Chen 7.1 Introduction 233 7.2 Controlled Drug Delivery Systems
Based on Organics Modified 7.3 Conclusions 258 References 259 Part III:
Nanotheragnostics 8 Responsive Polymer-Inorganic Hybrid Nanogels for
Optical Sensing, Imaging, and Drug Delivery 263 Weitai Wu and Shuiqin Zhou
8.1 Introduction 264 8.2 Mechanisms of Response 268 8.3 Synthesis of
Responsive Polymer-inorganic Hybrid Nanogels 285 8.4 Applications 293
References 306 9 Core/Shell Nanoparticles for Drug Delivery and Diagnosis
315 Hwanbum Lee, Jae Yeon Kim, Eun Hee Lee, Young In Park, Keun Sang Oh,
Kwangmeyung Kim, Ick Chan Kwonand Soon Hong Yuk 9.2 Core/Shell NPs from
Polymeric Micelles 319 9.3 Phospholipid-based Core/Shell Nanoparticles 325
9.4 Layer-by-Layer-Assembled Core/Shell Nanoparticles 329 9.5 Core/Shell
NPs for Diagnosis 330 9.4 Conclusions 331 Acknowledgments 331 References
331 10 Dendrimer Nanoparticles and Their Applications in Biomedicine 339
Arghya Paul, Wei Shao, Tom J. Burdon, Dominique Shum-Tim and Satya Prakash
10.1 Introduction 340 10.2 Dendrimers and Their Characteristics 341 10.3
Biomolecular Interactions of Dendrimer Nanocomplexes 343 10.4
PotentialApplications of Dendrimer in Nanomedicine 347 10.5 Conclusion 353
Acknowledgements 355 Indexing words 355 References 355 11 Theranostic
Nanoparticles for Cancer Imaging and Therapy 363 Mami Murakami, Mark J.
Ernsting and Shyh-Dar Li 11.1 Introduction 363 11.2 Multifunctional
Nanoparticles for Noninvasive 11.3 Multifunctional Nanoparticles for
Monitoring Drug Release 375 11.4 Theranostics to Image Therapeutic Response
380 11.5 Conclusion and Future Directions 382 Acknowledgement 383
References 383 Part IV: Nanoscaffolds technology 12 Nanostructure Polymers
in Function Generating Substitute and Organ Transplants 389 S.K. Shukla
12.1 Introduction 389 12.2 Important Nanopolymers 391 12.3
MedicalApplications 397 Acknowledgement 411 References 411 13 Electrospun
Nanofiberfor Three Dimensional Cell Culture 417 Yashpal Sharma, Ashutosh
Tiwari and Hisatoshi Kobayashi 13.1 Introduction 417 13.2 Nanofiber
Scaffolds Fabrication Techniques 419 13.3 Parameters of Electrospinning
Process 424 13.4 Electrospun Nanofibers for Three-dimensional Cell Culture
426 13.5 Conclusions 429 References 431 14 Magnetic Nanoparticles in Tissue
Regeneration 435 Anuj Tripathi, Jose Savio Melo and Stanislaus Francis
D'Souza 14.1 Introduction 435 14.2 Magnetic Nanoparticles: Physical
Properties 438 14.3 Synthesis of Magnetic Nanoparticles 440 14.4 Design and
Structure of Magnetic Nanoparticles 443 14.5 Stability and
Functionalization of Magnetic Nanoparticles 445 14.6 Cellular Toxicity of
Magnetic Nanoparticles 450 14.7 Tissue EngineeringApplications of Magnetic
Nanoparticles 453 14.8 Challenges and Future Prospects 473 Acknowledgement
474 References 474 15 Core-sheath Fibersfor Regenerative Medicine 485
Rajesh Vasita and Fabrizio Gelain 15.1 Introduction 486 15.2 Core-sheath
Nanofiber Technology 489 15.3Application of Core-sheath Nanofibers 504 15.4
Conclusions 519 References 519
Stability and Application in Biosciences 1 Thomas Delmas, Nicolas
Atrux-Tallau, Mathieu Goutayer, SangHoon Han, Jin Woong Kim, and Jérôme
Bibette 1.1 Introduction 2 1.2 Nanoemulsion:A Thermodynamic Definition and
Its Practical Implications 5 1.3 Stable Nanoemulsion Formulation 9 1.4
Nanoencapsulation in Lipid Nanoparticles 21 1.5 Interactions between
Nanoemulsions and the Biological Medium: Applications in Biosciences 35 1.6
General Conclusion 47 References 48 2 Multifunctional Polymeric
Nanostructures for Therapy and Diagnosis 57 Angel Contreras-García and
Emilio Bucio 2.1 Introduction 58 2.2 Polymeric-based Core-shell Colloid 61
2.3 Proteins and Peptides 64 2.4 Drug Conjugates and Complexes with
Synthetic Polymers 65 2.5 Dendrimers, Vesicles, and Micelles 67 2.6 Smart
Nanopolymers 71 2.7 Stimuli Responsive Polymer-metal Nanocomposites 75 2.8
Enzyme-responsive Nanoparticles 78 Acknowledgements 83 References 83 3
Carbon Nanotubes: Nanotoxicity Testing and Bioapplications 97 R. Sharma and
S. Kwon 3.1 Introduction 98 3.2 Historical Review of Carbon Nanotube 99 3.3
Carbon Nanotubes (CNTs) and Other Carbon Nanomaterials 100 3.4 Motivation -
Combining Nanotechnology and Surface Science with Growing Bioapplications
104 3.5 Cytotoxicity Measurement and Mechanisms of CNT Toxicity 111 3.6
MSCs Differentiation and Proliferation on Different Types of Scaffolds 120
3.7 New Lessons on CNT Nanocomposites 130 3.8 Conclusions 135 Part II:
Advanced nanomedicine 4 Discrete Metalla-Assemblies as Drug Delivery
Vectors 149 Bruno Therrien 4.1 Introduction 149 4.2 Complex-in-a-Complex
Systems 150 4.3 Encapsulation of Pyrenyl-functionalized Derivatives 155 4.4
Exploiting the Enhanced Permeability and Retention Effect 159 4.5
Incorporation of Photosensitizers in Metalla-assemblies 162 4.6 Conclusion
165 Acknowledgments 165 References 166 5 Nanomaterials for Management of
Lung Disorders and Drug Delivery 169 Jyothi U. Menon, Aniket S. Wadajkar,
Zhiwe iXie, and Kytai T. Nguyen 5.1 Lung Structure and Physiology 170 5.2
Common Lung DiseasesAnd Treatment Methods 171 5.3 Types of Nanoparticles
(NPs) 173 5.4 Methods for Pulmonary Delivery 179 5.5 Targeting Mechanisms
184 5.6 TherapeuticAgents Used for Delivery 188 5.7 Applications 191 5.8
Design Considerations of NPs 195 5.9 Current Challenges and Future Outlook
197 6 Nano-Sized Calcium Phosphate (CaP) Carriers for Non-Viral Gene/Drug
Delivery 199 Donghyun Lee, Geunseon Ahn and Prashant N. Kumta 6.1
Introduction 200 6.2 Vectors for Gene Delivery 202 6.3 Modulation of
Protection and Release Characteristics of Calcium Phosphate Vector 213 6.4
Calcium Phosphate Carriers for Drug Delivery Systems 219 6.5 Variants of
Nano-calcium Phosphates: Future Trends of the CaPDelivery Systems 221
Acknowledgements 223 References 223 7 Organics ModifiedMesoporous Silica
for Controlled Drug Delivery Systems 233 Jingke Fu, Yang Zhao, Yingchun Zhu
and Fang Chen 7.1 Introduction 233 7.2 Controlled Drug Delivery Systems
Based on Organics Modified 7.3 Conclusions 258 References 259 Part III:
Nanotheragnostics 8 Responsive Polymer-Inorganic Hybrid Nanogels for
Optical Sensing, Imaging, and Drug Delivery 263 Weitai Wu and Shuiqin Zhou
8.1 Introduction 264 8.2 Mechanisms of Response 268 8.3 Synthesis of
Responsive Polymer-inorganic Hybrid Nanogels 285 8.4 Applications 293
References 306 9 Core/Shell Nanoparticles for Drug Delivery and Diagnosis
315 Hwanbum Lee, Jae Yeon Kim, Eun Hee Lee, Young In Park, Keun Sang Oh,
Kwangmeyung Kim, Ick Chan Kwonand Soon Hong Yuk 9.2 Core/Shell NPs from
Polymeric Micelles 319 9.3 Phospholipid-based Core/Shell Nanoparticles 325
9.4 Layer-by-Layer-Assembled Core/Shell Nanoparticles 329 9.5 Core/Shell
NPs for Diagnosis 330 9.4 Conclusions 331 Acknowledgments 331 References
331 10 Dendrimer Nanoparticles and Their Applications in Biomedicine 339
Arghya Paul, Wei Shao, Tom J. Burdon, Dominique Shum-Tim and Satya Prakash
10.1 Introduction 340 10.2 Dendrimers and Their Characteristics 341 10.3
Biomolecular Interactions of Dendrimer Nanocomplexes 343 10.4
PotentialApplications of Dendrimer in Nanomedicine 347 10.5 Conclusion 353
Acknowledgements 355 Indexing words 355 References 355 11 Theranostic
Nanoparticles for Cancer Imaging and Therapy 363 Mami Murakami, Mark J.
Ernsting and Shyh-Dar Li 11.1 Introduction 363 11.2 Multifunctional
Nanoparticles for Noninvasive 11.3 Multifunctional Nanoparticles for
Monitoring Drug Release 375 11.4 Theranostics to Image Therapeutic Response
380 11.5 Conclusion and Future Directions 382 Acknowledgement 383
References 383 Part IV: Nanoscaffolds technology 12 Nanostructure Polymers
in Function Generating Substitute and Organ Transplants 389 S.K. Shukla
12.1 Introduction 389 12.2 Important Nanopolymers 391 12.3
MedicalApplications 397 Acknowledgement 411 References 411 13 Electrospun
Nanofiberfor Three Dimensional Cell Culture 417 Yashpal Sharma, Ashutosh
Tiwari and Hisatoshi Kobayashi 13.1 Introduction 417 13.2 Nanofiber
Scaffolds Fabrication Techniques 419 13.3 Parameters of Electrospinning
Process 424 13.4 Electrospun Nanofibers for Three-dimensional Cell Culture
426 13.5 Conclusions 429 References 431 14 Magnetic Nanoparticles in Tissue
Regeneration 435 Anuj Tripathi, Jose Savio Melo and Stanislaus Francis
D'Souza 14.1 Introduction 435 14.2 Magnetic Nanoparticles: Physical
Properties 438 14.3 Synthesis of Magnetic Nanoparticles 440 14.4 Design and
Structure of Magnetic Nanoparticles 443 14.5 Stability and
Functionalization of Magnetic Nanoparticles 445 14.6 Cellular Toxicity of
Magnetic Nanoparticles 450 14.7 Tissue EngineeringApplications of Magnetic
Nanoparticles 453 14.8 Challenges and Future Prospects 473 Acknowledgement
474 References 474 15 Core-sheath Fibersfor Regenerative Medicine 485
Rajesh Vasita and Fabrizio Gelain 15.1 Introduction 486 15.2 Core-sheath
Nanofiber Technology 489 15.3Application of Core-sheath Nanofibers 504 15.4
Conclusions 519 References 519
Preface xv Part I: Biomedical nanomaterials 1 Nanoemulsions: Preparation,
Stability and Application in Biosciences 1 Thomas Delmas, Nicolas
Atrux-Tallau, Mathieu Goutayer, SangHoon Han, Jin Woong Kim, and Jérôme
Bibette 1.1 Introduction 2 1.2 Nanoemulsion:A Thermodynamic Definition and
Its Practical Implications 5 1.3 Stable Nanoemulsion Formulation 9 1.4
Nanoencapsulation in Lipid Nanoparticles 21 1.5 Interactions between
Nanoemulsions and the Biological Medium: Applications in Biosciences 35 1.6
General Conclusion 47 References 48 2 Multifunctional Polymeric
Nanostructures for Therapy and Diagnosis 57 Angel Contreras-García and
Emilio Bucio 2.1 Introduction 58 2.2 Polymeric-based Core-shell Colloid 61
2.3 Proteins and Peptides 64 2.4 Drug Conjugates and Complexes with
Synthetic Polymers 65 2.5 Dendrimers, Vesicles, and Micelles 67 2.6 Smart
Nanopolymers 71 2.7 Stimuli Responsive Polymer-metal Nanocomposites 75 2.8
Enzyme-responsive Nanoparticles 78 Acknowledgements 83 References 83 3
Carbon Nanotubes: Nanotoxicity Testing and Bioapplications 97 R. Sharma and
S. Kwon 3.1 Introduction 98 3.2 Historical Review of Carbon Nanotube 99 3.3
Carbon Nanotubes (CNTs) and Other Carbon Nanomaterials 100 3.4 Motivation -
Combining Nanotechnology and Surface Science with Growing Bioapplications
104 3.5 Cytotoxicity Measurement and Mechanisms of CNT Toxicity 111 3.6
MSCs Differentiation and Proliferation on Different Types of Scaffolds 120
3.7 New Lessons on CNT Nanocomposites 130 3.8 Conclusions 135 Part II:
Advanced nanomedicine 4 Discrete Metalla-Assemblies as Drug Delivery
Vectors 149 Bruno Therrien 4.1 Introduction 149 4.2 Complex-in-a-Complex
Systems 150 4.3 Encapsulation of Pyrenyl-functionalized Derivatives 155 4.4
Exploiting the Enhanced Permeability and Retention Effect 159 4.5
Incorporation of Photosensitizers in Metalla-assemblies 162 4.6 Conclusion
165 Acknowledgments 165 References 166 5 Nanomaterials for Management of
Lung Disorders and Drug Delivery 169 Jyothi U. Menon, Aniket S. Wadajkar,
Zhiwe iXie, and Kytai T. Nguyen 5.1 Lung Structure and Physiology 170 5.2
Common Lung DiseasesAnd Treatment Methods 171 5.3 Types of Nanoparticles
(NPs) 173 5.4 Methods for Pulmonary Delivery 179 5.5 Targeting Mechanisms
184 5.6 TherapeuticAgents Used for Delivery 188 5.7 Applications 191 5.8
Design Considerations of NPs 195 5.9 Current Challenges and Future Outlook
197 6 Nano-Sized Calcium Phosphate (CaP) Carriers for Non-Viral Gene/Drug
Delivery 199 Donghyun Lee, Geunseon Ahn and Prashant N. Kumta 6.1
Introduction 200 6.2 Vectors for Gene Delivery 202 6.3 Modulation of
Protection and Release Characteristics of Calcium Phosphate Vector 213 6.4
Calcium Phosphate Carriers for Drug Delivery Systems 219 6.5 Variants of
Nano-calcium Phosphates: Future Trends of the CaPDelivery Systems 221
Acknowledgements 223 References 223 7 Organics ModifiedMesoporous Silica
for Controlled Drug Delivery Systems 233 Jingke Fu, Yang Zhao, Yingchun Zhu
and Fang Chen 7.1 Introduction 233 7.2 Controlled Drug Delivery Systems
Based on Organics Modified 7.3 Conclusions 258 References 259 Part III:
Nanotheragnostics 8 Responsive Polymer-Inorganic Hybrid Nanogels for
Optical Sensing, Imaging, and Drug Delivery 263 Weitai Wu and Shuiqin Zhou
8.1 Introduction 264 8.2 Mechanisms of Response 268 8.3 Synthesis of
Responsive Polymer-inorganic Hybrid Nanogels 285 8.4 Applications 293
References 306 9 Core/Shell Nanoparticles for Drug Delivery and Diagnosis
315 Hwanbum Lee, Jae Yeon Kim, Eun Hee Lee, Young In Park, Keun Sang Oh,
Kwangmeyung Kim, Ick Chan Kwonand Soon Hong Yuk 9.2 Core/Shell NPs from
Polymeric Micelles 319 9.3 Phospholipid-based Core/Shell Nanoparticles 325
9.4 Layer-by-Layer-Assembled Core/Shell Nanoparticles 329 9.5 Core/Shell
NPs for Diagnosis 330 9.4 Conclusions 331 Acknowledgments 331 References
331 10 Dendrimer Nanoparticles and Their Applications in Biomedicine 339
Arghya Paul, Wei Shao, Tom J. Burdon, Dominique Shum-Tim and Satya Prakash
10.1 Introduction 340 10.2 Dendrimers and Their Characteristics 341 10.3
Biomolecular Interactions of Dendrimer Nanocomplexes 343 10.4
PotentialApplications of Dendrimer in Nanomedicine 347 10.5 Conclusion 353
Acknowledgements 355 Indexing words 355 References 355 11 Theranostic
Nanoparticles for Cancer Imaging and Therapy 363 Mami Murakami, Mark J.
Ernsting and Shyh-Dar Li 11.1 Introduction 363 11.2 Multifunctional
Nanoparticles for Noninvasive 11.3 Multifunctional Nanoparticles for
Monitoring Drug Release 375 11.4 Theranostics to Image Therapeutic Response
380 11.5 Conclusion and Future Directions 382 Acknowledgement 383
References 383 Part IV: Nanoscaffolds technology 12 Nanostructure Polymers
in Function Generating Substitute and Organ Transplants 389 S.K. Shukla
12.1 Introduction 389 12.2 Important Nanopolymers 391 12.3
MedicalApplications 397 Acknowledgement 411 References 411 13 Electrospun
Nanofiberfor Three Dimensional Cell Culture 417 Yashpal Sharma, Ashutosh
Tiwari and Hisatoshi Kobayashi 13.1 Introduction 417 13.2 Nanofiber
Scaffolds Fabrication Techniques 419 13.3 Parameters of Electrospinning
Process 424 13.4 Electrospun Nanofibers for Three-dimensional Cell Culture
426 13.5 Conclusions 429 References 431 14 Magnetic Nanoparticles in Tissue
Regeneration 435 Anuj Tripathi, Jose Savio Melo and Stanislaus Francis
D'Souza 14.1 Introduction 435 14.2 Magnetic Nanoparticles: Physical
Properties 438 14.3 Synthesis of Magnetic Nanoparticles 440 14.4 Design and
Structure of Magnetic Nanoparticles 443 14.5 Stability and
Functionalization of Magnetic Nanoparticles 445 14.6 Cellular Toxicity of
Magnetic Nanoparticles 450 14.7 Tissue EngineeringApplications of Magnetic
Nanoparticles 453 14.8 Challenges and Future Prospects 473 Acknowledgement
474 References 474 15 Core-sheath Fibersfor Regenerative Medicine 485
Rajesh Vasita and Fabrizio Gelain 15.1 Introduction 486 15.2 Core-sheath
Nanofiber Technology 489 15.3Application of Core-sheath Nanofibers 504 15.4
Conclusions 519 References 519
Stability and Application in Biosciences 1 Thomas Delmas, Nicolas
Atrux-Tallau, Mathieu Goutayer, SangHoon Han, Jin Woong Kim, and Jérôme
Bibette 1.1 Introduction 2 1.2 Nanoemulsion:A Thermodynamic Definition and
Its Practical Implications 5 1.3 Stable Nanoemulsion Formulation 9 1.4
Nanoencapsulation in Lipid Nanoparticles 21 1.5 Interactions between
Nanoemulsions and the Biological Medium: Applications in Biosciences 35 1.6
General Conclusion 47 References 48 2 Multifunctional Polymeric
Nanostructures for Therapy and Diagnosis 57 Angel Contreras-García and
Emilio Bucio 2.1 Introduction 58 2.2 Polymeric-based Core-shell Colloid 61
2.3 Proteins and Peptides 64 2.4 Drug Conjugates and Complexes with
Synthetic Polymers 65 2.5 Dendrimers, Vesicles, and Micelles 67 2.6 Smart
Nanopolymers 71 2.7 Stimuli Responsive Polymer-metal Nanocomposites 75 2.8
Enzyme-responsive Nanoparticles 78 Acknowledgements 83 References 83 3
Carbon Nanotubes: Nanotoxicity Testing and Bioapplications 97 R. Sharma and
S. Kwon 3.1 Introduction 98 3.2 Historical Review of Carbon Nanotube 99 3.3
Carbon Nanotubes (CNTs) and Other Carbon Nanomaterials 100 3.4 Motivation -
Combining Nanotechnology and Surface Science with Growing Bioapplications
104 3.5 Cytotoxicity Measurement and Mechanisms of CNT Toxicity 111 3.6
MSCs Differentiation and Proliferation on Different Types of Scaffolds 120
3.7 New Lessons on CNT Nanocomposites 130 3.8 Conclusions 135 Part II:
Advanced nanomedicine 4 Discrete Metalla-Assemblies as Drug Delivery
Vectors 149 Bruno Therrien 4.1 Introduction 149 4.2 Complex-in-a-Complex
Systems 150 4.3 Encapsulation of Pyrenyl-functionalized Derivatives 155 4.4
Exploiting the Enhanced Permeability and Retention Effect 159 4.5
Incorporation of Photosensitizers in Metalla-assemblies 162 4.6 Conclusion
165 Acknowledgments 165 References 166 5 Nanomaterials for Management of
Lung Disorders and Drug Delivery 169 Jyothi U. Menon, Aniket S. Wadajkar,
Zhiwe iXie, and Kytai T. Nguyen 5.1 Lung Structure and Physiology 170 5.2
Common Lung DiseasesAnd Treatment Methods 171 5.3 Types of Nanoparticles
(NPs) 173 5.4 Methods for Pulmonary Delivery 179 5.5 Targeting Mechanisms
184 5.6 TherapeuticAgents Used for Delivery 188 5.7 Applications 191 5.8
Design Considerations of NPs 195 5.9 Current Challenges and Future Outlook
197 6 Nano-Sized Calcium Phosphate (CaP) Carriers for Non-Viral Gene/Drug
Delivery 199 Donghyun Lee, Geunseon Ahn and Prashant N. Kumta 6.1
Introduction 200 6.2 Vectors for Gene Delivery 202 6.3 Modulation of
Protection and Release Characteristics of Calcium Phosphate Vector 213 6.4
Calcium Phosphate Carriers for Drug Delivery Systems 219 6.5 Variants of
Nano-calcium Phosphates: Future Trends of the CaPDelivery Systems 221
Acknowledgements 223 References 223 7 Organics ModifiedMesoporous Silica
for Controlled Drug Delivery Systems 233 Jingke Fu, Yang Zhao, Yingchun Zhu
and Fang Chen 7.1 Introduction 233 7.2 Controlled Drug Delivery Systems
Based on Organics Modified 7.3 Conclusions 258 References 259 Part III:
Nanotheragnostics 8 Responsive Polymer-Inorganic Hybrid Nanogels for
Optical Sensing, Imaging, and Drug Delivery 263 Weitai Wu and Shuiqin Zhou
8.1 Introduction 264 8.2 Mechanisms of Response 268 8.3 Synthesis of
Responsive Polymer-inorganic Hybrid Nanogels 285 8.4 Applications 293
References 306 9 Core/Shell Nanoparticles for Drug Delivery and Diagnosis
315 Hwanbum Lee, Jae Yeon Kim, Eun Hee Lee, Young In Park, Keun Sang Oh,
Kwangmeyung Kim, Ick Chan Kwonand Soon Hong Yuk 9.2 Core/Shell NPs from
Polymeric Micelles 319 9.3 Phospholipid-based Core/Shell Nanoparticles 325
9.4 Layer-by-Layer-Assembled Core/Shell Nanoparticles 329 9.5 Core/Shell
NPs for Diagnosis 330 9.4 Conclusions 331 Acknowledgments 331 References
331 10 Dendrimer Nanoparticles and Their Applications in Biomedicine 339
Arghya Paul, Wei Shao, Tom J. Burdon, Dominique Shum-Tim and Satya Prakash
10.1 Introduction 340 10.2 Dendrimers and Their Characteristics 341 10.3
Biomolecular Interactions of Dendrimer Nanocomplexes 343 10.4
PotentialApplications of Dendrimer in Nanomedicine 347 10.5 Conclusion 353
Acknowledgements 355 Indexing words 355 References 355 11 Theranostic
Nanoparticles for Cancer Imaging and Therapy 363 Mami Murakami, Mark J.
Ernsting and Shyh-Dar Li 11.1 Introduction 363 11.2 Multifunctional
Nanoparticles for Noninvasive 11.3 Multifunctional Nanoparticles for
Monitoring Drug Release 375 11.4 Theranostics to Image Therapeutic Response
380 11.5 Conclusion and Future Directions 382 Acknowledgement 383
References 383 Part IV: Nanoscaffolds technology 12 Nanostructure Polymers
in Function Generating Substitute and Organ Transplants 389 S.K. Shukla
12.1 Introduction 389 12.2 Important Nanopolymers 391 12.3
MedicalApplications 397 Acknowledgement 411 References 411 13 Electrospun
Nanofiberfor Three Dimensional Cell Culture 417 Yashpal Sharma, Ashutosh
Tiwari and Hisatoshi Kobayashi 13.1 Introduction 417 13.2 Nanofiber
Scaffolds Fabrication Techniques 419 13.3 Parameters of Electrospinning
Process 424 13.4 Electrospun Nanofibers for Three-dimensional Cell Culture
426 13.5 Conclusions 429 References 431 14 Magnetic Nanoparticles in Tissue
Regeneration 435 Anuj Tripathi, Jose Savio Melo and Stanislaus Francis
D'Souza 14.1 Introduction 435 14.2 Magnetic Nanoparticles: Physical
Properties 438 14.3 Synthesis of Magnetic Nanoparticles 440 14.4 Design and
Structure of Magnetic Nanoparticles 443 14.5 Stability and
Functionalization of Magnetic Nanoparticles 445 14.6 Cellular Toxicity of
Magnetic Nanoparticles 450 14.7 Tissue EngineeringApplications of Magnetic
Nanoparticles 453 14.8 Challenges and Future Prospects 473 Acknowledgement
474 References 474 15 Core-sheath Fibersfor Regenerative Medicine 485
Rajesh Vasita and Fabrizio Gelain 15.1 Introduction 486 15.2 Core-sheath
Nanofiber Technology 489 15.3Application of Core-sheath Nanofibers 504 15.4
Conclusions 519 References 519