Inhibitors of the Ras Superfamily G-Proteins, Part B

Volume 34
Herausgegeben:Tamanoi, Fuyuhiko; Der, Channing J.

• Gebundenes Buch

Produktbeschreibung

Targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer, this is the second part of The Enzymes' volumes that discuss inhibitors of the Ras superfamily G-proteins.

Produktdetails

• The Enzymes Volume 34
• Verlag: Academic Press / Elsevier Science & Technology
• Artikelnr. des Verlages: C2012-0-03661-7
• Seitenzahl: 280
• Erscheinungstermin: 25. November 2013
• Englisch
• Abmessung: 236mm x 158mm x 20mm
• Gewicht: 570g
• ISBN-13: 9780124201460
• ISBN-10: 0124201466
• Artikelnr.: 39354847

Autorenporträt

Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997.

Inhaltsangabe

1. Discovery of Small-Molecule Ras Inhibitors that Display Anti-Tumor Activity by Interfering with Ras.GTP-Effector InteractionFumi Shima, Yoko Yoshikawa, Shigeyuki Matsumoto and Tohru Kataoka
2. An Orthosteric Inhibitor of the RAS-SOS InteractionSeth Nickerson, Stephen T. Joy, Paramjit S. Arora and Dafna Bar-Sagi
3. Conformation-Specific Inhibitors of Raf kinasesXiaolun Wang and Kristin Schleicher
4. Inhibitors of the ERK Mitogen-activated Protein Kinase Cascade for Targeting RAS Mutant CancersLeanna Gentry, Ahmed A. Samatar and Channing J. Der
5. Inhibiting the RAS - PI3K Pathway in Cancer TherapyClare Sheridan and Julian Downward
6. The RalGEF/Ral Pathway: Evaluating an Intervention Opportunity for Ras CancersJonathan M. Cooper, Brian O. Bodemann and Michael A. White
7. p21-Activated Kinase InhibitorsJoachim Rudolph, James J. Crawford, Klaus P. Hoeflich, and Jonathan Chernoff
8. Recent Progress in Developing Small Molecule Inhibitors Designed to Interfere with Ras Membrane Association: Towards Inhibiting K-Ras and N-Ras Functions Fuyuhiko Tamanoi and Jie Lu
9. Synthetic Lethal Genetic Screens in Ras Mutant CancersBing Yu and Ji Luo