Inhibitors of the Ras Superfamily G-proteins, Part B (eBook, ePUB)

• Format: ePub

Produktbeschreibung

Targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer, this is the second part of The Enzymes' volumes that discuss inhibitors of the Ras superfamily G-proteins.

• Informs and updates on all the latest developments in the field
• Contributions from leading authorities and industry experts

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 280
• Erscheinungstermin: 7. November 2013
• Englisch
• ISBN-13: 9780124202115
• Artikelnr.: 40022342

Autorenporträt

Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997.

Inhaltsangabe

1. Discovery of Small-Molecule Ras Inhibitors that Display Anti-Tumor Activity by Interfering with Ras.GTP-Effector InteractionFumi Shima, Yoko Yoshikawa, Shigeyuki Matsumoto and Tohru Kataoka
2. An Orthosteric Inhibitor of the RAS-SOS InteractionSeth Nickerson, Stephen T. Joy, Paramjit S. Arora and Dafna Bar-Sagi
3. Conformation-Specific Inhibitors of Raf kinasesXiaolun Wang and Kristin Schleicher
4. Inhibitors of the ERK Mitogen-activated Protein Kinase Cascade for Targeting RAS Mutant CancersLeanna Gentry, Ahmed A. Samatar and Channing J. Der
5. Inhibiting the RAS - PI3K Pathway in Cancer TherapyClare Sheridan and Julian Downward
6. The RalGEF/Ral Pathway: Evaluating an Intervention Opportunity for Ras CancersJonathan M. Cooper, Brian O. Bodemann and Michael A. White
7. p21-Activated Kinase InhibitorsJoachim Rudolph, James J. Crawford, Klaus P. Hoeflich, and Jonathan Chernoff
8. Recent Progress in Developing Small Molecule Inhibitors Designed to Interfere with Ras Membrane Association: Towards Inhibiting K-Ras and N-Ras Functions Fuyuhiko Tamanoi and Jie Lu
9. Synthetic Lethal Genetic Screens in Ras Mutant CancersBing Yu and Ji Luo