Chronic Kidney Disease and RAAS Blockade: A New view of Renoprotection - Onuigbo, Macaulay;Onuigbo, Nnonyelum
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Despite an increasing use of ACE inhibitors (ACEIs) and angiotensin receptor blockers (ARB) by tens of millions of chronic kidney disease (CKD) patients around the world for reno-protection, we have continued to witness global pandemics of acute renal failure, CKD and end-stage renal disease. While the mechanisms for these global pandemics remain speculative, there is accruing evidence of iatrogenic renal failure from ACEIs and ARBs. Since 2005, we have published an increasing number of such reports from our center. More complimentary reports from around the world have surfaced in recent…mehr

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Produktbeschreibung
Despite an increasing use of ACE inhibitors (ACEIs) and angiotensin receptor blockers (ARB) by tens of millions of chronic kidney disease (CKD) patients around the world for reno-protection, we have continued to witness global pandemics of acute renal failure, CKD and end-stage renal disease. While the mechanisms for these global pandemics remain speculative, there is accruing evidence of iatrogenic renal failure from ACEIs and ARBs. Since 2005, we have published an increasing number of such reports from our center. More complimentary reports from around the world have surfaced in recent years. We described two new syndromes - late onset renal failure from angiotensin blockade (LORFFAB) and the syndrome of rapid onset end-stage renal disease (SORO-ESRD). This book is an amalgam of all our work with new unpublished data. The contributions of LORFFAB and SORO-ESRD to the global pandemics warrant worldwide study. Finally, this work presents a very balanced review of the evidence base for reno-protection with ACEIs and ARBs and should be especially useful to medical professionals in Family Medicine, Internal Medicine, Nephrology and Hypertension, Emergency Medicine and Cardiology.
Autorenporträt
Dr. Onuigbo, Associate Professor of Medicine and Nephrologist, Mayo Clinic, Rochester, USA., Mayo MacMillan Scholar, Fellow of the American Society of Nephrology, Mayo SOAR Grant recipient, over 80 publications, two book chapters, MBBS and MSc degrees (University of Nigeria). We described two new syndromes ¿ LORFFAB in 2005 and SORO-ESRD in 2010.