Cancer and Inflammation (eBook, PDF)

Redaktion: Chadwick, Derek J.; Goode, Jamie A.

• Format: PDF

Produktbeschreibung

Chronic inflammation predisposes to some forms of cancer and the host response to malignant disease shows several parallels with inflammation and wound healing. The cells involved in inflammation are detected in a range of common cancers, together with the inflammatory cytokines and members of the chemokine ligand/receptor systems. Neutralization or deletion of the gene for some inflammatory cytokines confers resistance to tumour induction and experimental metastasis. Over-expression of such cytokines in tumour cells may enhance malignant potential. Certain chemokines are likely to subvert antitumour immunity by favouring development of ineffective Type 2 responses. Tumour cells may even utilize chemokine receptors in homing to lymph nodes and other organs. Thus, the cells, cytokines and chemokines found in tumours are more likely to contribute to tumour growth, progression and immunosuppression than they are to mount an effective host antitumour response. This book draws together contributions from an international group of scientists and clinicians from diverse disciplines, ranging from epidemiology to immunology, cell biology, molecular oncology, molecular medicine and pharmacology to debate these and related issues. Topics covered include the epidemiological links between cancer and inflammation, the parallels between inflammation and cancer, the role of inflammation in cancer, inflammatory genes as risk factors for cancer initiation and progression, inflammation and cancer angiogenesis, and preventative and therapeutic strategies. Related Novartis Foundation symposia: 252 Generation and Effector Functions of Regulatory Lymphocytes Chair: Jean-François Bach 254 Immunoinformatics: Bioinformatic Strategies for Better Understanding of Immune Function Chair: Hans-Georg Rammensee

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 290
• Erscheinungstermin: 6. Mai 2004
• Englisch
• ISBN-13: 9780470856727
• Artikelnr.: 37299449

Autorenporträt

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research. Chair: SIAMON GORDON, Sir William Dunn School of Pathology, University of Oxford, UK

Inhaltsangabe

Chair's Introduction (S. Gordon). Inflammation and cancer: an
epidemiological perspective (M. Thun, et al.). Chemokine-based pathogenetic
mechanisms in cancer (I. Conti, et al.). General Discussion I. Anti-TNF
therapy of rheumatoid arthritis: what can we learn about chronic disease?
(M. Feldmann, et al.). How do chemokine/chemokine receptor activations
affect tumorigenesis? (A. Richmond, et al.). Proinflammatory cytokines,
immune response and tumour progression (M. Spadaro and G. Forni). General
discussion II. Lymphangiogenesis and tumour metastasis (J. Tille, et al.).
Infiltration of tumours by macrophages and dendritic cells:
tumour-associated macrophages as a paradigm for polarized M2 mononuclear
phagocytes (A. Mantovani, et al.). The influence of CD25+ cells on the
generation of immunity to tumour cell-lines in mice (E. Jones, et al.).
Macrophages: modulators of breast cancer progression (E. Lin and J.
Pollard). Chemokines: angiogenesis and metastases in lung cancer (R.
Strieter, et al.). Macrophage infiltration and angiogenesis in human
malignancy (H. Knowles, et al.). The role of inflammation for tumour growth
and tumour suppression (T. Blankenstein). Cyclooxygenase 2: from
inflammation to carcinogenesis (A. Ristimäki). The inflammatory cytokine
network of epithelial cancer: therapeutic implications (P. Szlosarek and F.
Balkwill). In vivo manipulation of DC migration and activation to elicit
anti-tumour immunity (A. Vicari, et al.). Final general discussion.
Concluding remarks (S. Gordon). Index of contributors. Subject Index.