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Chronic inflammation predisposes to some forms of cancer and thehost response to malignant disease shows several parallels withinflammation and wound healing. The cells involved in inflammationare detected in a range of common cancers, together with theinflammatory cytokines and members of the chemokine ligand/receptorsystems. Neutralization or deletion of the gene for some inflammatorycytokines confers resistance to tumour induction and experimentalmetastasis. Over-expression of such cytokines in tumour cells mayenhance malignant potential. Certain chemokines are likely tosubvert antitumour…mehr

Produktbeschreibung
Chronic inflammation predisposes to some forms of cancer and thehost response to malignant disease shows several parallels withinflammation and wound healing. The cells involved in inflammationare detected in a range of common cancers, together with theinflammatory cytokines and members of the chemokine ligand/receptorsystems. Neutralization or deletion of the gene for some inflammatorycytokines confers resistance to tumour induction and experimentalmetastasis. Over-expression of such cytokines in tumour cells mayenhance malignant potential. Certain chemokines are likely tosubvert antitumour immunity by favouring development of ineffectiveType 2 responses. Tumour cells may even utilize chemokine receptorsin homing to lymph nodes and other organs. Thus, the cells,cytokines and chemokines found in tumours are more likely tocontribute to tumour growth, progression and immunosuppression thanthey are to mount an effective host antitumour response. This book draws together contributions from an international groupof scientists and clinicians from diverse disciplines, ranging fromepidemiology to immunology, cell biology, molecular oncology,molecular medicine and pharmacology to debate these and relatedissues. Topics covered include the epidemiological links betweencancer and inflammation, the parallels between inflammation andcancer, the role of inflammation in cancer, inflammatory genes asrisk factors for cancer initiation and progression, inflammationand cancer angiogenesis, and preventative and therapeuticstrategies. Related Novartis Foundation symposia: 252 Generation and Effector Functions of RegulatoryLymphocytes Chair: Jean-François Bach 254 Immunoinformatics: Bioinformatic Strategies for BetterUnderstanding of Immune Function Chair: Hans-Georg Rammensee

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  • Produktdetails
  • Verlag: John Wiley & Sons
  • Seitenzahl: 290
  • Erscheinungstermin: 06.05.2004
  • Englisch
  • ISBN-13: 9780470856727
  • Artikelnr.: 37299449
Inhaltsangabe
Chair's Introduction (S. Gordon).
Inflammation and cancer: an epidemiological perspective (M. Thun, et al.).
Chemokine-based pathogenetic mechanisms in cancer (I. Conti, et al.).
General Discussion I.
Anti-TNF therapy of rheumatoid arthritis: what can we learn about chronic disease? (M. Feldmann, et al.).
How do chemokine/chemokine receptor activations affect tumorigenesis? (A. Richmond, et al.).
Proinflammatory cytokines, immune response and tumour progression (M. Spadaro and G. Forni).
General discussion II.
Lymphangiogenesis and tumour metastasis (J. Tille, et al.).
Infiltration of tumours by macrophages and dendritic cells: tumour-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes (A. Mantovani, et al.).
The influence of CD25+ cells on the generation of immunity to tumour cell-lines in mice (E. Jones, et al.).
Macrophages: modulators of breast cancer progression (E. Lin and J. Pollard).
Chemokines: angiogenesis and metastases in lung cancer (R. Strieter, et al.).
Macrophage infiltration and angiogenesis in human malignancy (H. Knowles, et al.).
The role of inflammation for tumour growth and tumour suppression (T. Blankenstein).
Cyclooxygenase 2: from inflammation to carcinogenesis (A. Ristimäki).
The inflammatory cytokine network of epithelial cancer: therapeutic implications (P. Szlosarek and F. Balkwill).
In vivo manipulation of DC migration and activation to elicit anti-tumour immunity (A. Vicari, et al.).
Final general discussion.
Concluding remarks (S. Gordon).
Index of contributors.
Subject Index.