Sotiris Missailidis

Anticancer Therapeutics (eBook, PDF)

• Format: PDF

Produktbeschreibung

Written by the winner of the 2008 Mike Price Fellowship "This volume provides a comprehensive overview of the wealth of information now available in this important and fast-moving subject." Anticancer Research, November - December 2008 This book provides a clear introduction to the area, with an overview of the various drug design and development approaches for cancer therapeutics and their progress in today's multidisciplinary approach to cancer treatment. Clearly structured throughout, the book not only provides information on currently used molecular treatment approaches, but also describes the various agents that are currently at various stages of development and clinical trials, thus making them the drugs of tomorrow. The book goes on to present current therapeutic regimes including their indications and side effects, as well as their position in the international market in terms of sales and development costs. Furthermore, coverage of our advancement in the understanding of cancer biology and how this has driven the drug discovery process is clearly discussed. Modern drug discovery aspects, through genomic, proteomic and metabolomic approaches are referred to as well as combinatorial chemistry techniques and discovery of chemotherapeutic agents from plant extracts, re-use of old drugs and drugs from other indications, or de novo rational drug design. Including contributions from leading experts in the field, this book provides the reader with a complete overview of the various types of therapeutic agents, current and emerging, as well as other aspects associated with anticancer therapy, drug design, resistance and clinical trials in oncology.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 424
• Erscheinungstermin: 13. Oktober 2008
• Englisch
• ISBN-13: 9780470697030
• Artikelnr.: 37298875

Autorenporträt

Dr Sotiris Missailidis. Department of Chemistry and Analytical Sciences, The Open University, Milton Keynes, UK.

Inhaltsangabe

Contributors. Preface. SECTION I: DEVELOPMENT OF ANTICANCER THERAPEUTICS.
1. Exploring the potential of natural products in cancer treatment (Fotini
N. Lamari and Paul Cordopatis). 2. Combinatorial approach to anticancer
drug design (Sotiris Missailidis). 3. Rational approaches to anticancer
drug design/in silico drug development (Stefano Alcaro, Anna Artese and
Francesco Ortuso). SECTION II: ANTICANCER THERAPEUTICS. 4. Introduction
(Teni Boulikas). 5. Platinum drugs (Teni Boulikas, Alexandros Pantos,
Evagelos Bellis and Petros Christofis). 6. Antimicrotubule agents (Iain
Brown, Jay N Sangrithi-Wallace and Andrew C Schofield). 7. Antimetabolites
in cancer therapy (Jessica Scaiffe and David Kerr). 8. Antitumour
antibiotics (Manuel M. Paz). 9. Alkylating agents (Ana Paula Francisco,
Maria de Jesus Perry, Eduarda Mendes and Rui Moreira). 10. Hormone
therapies (George C. Zografos, Nikolaos V. Michalopoulos and Flora
Zagouri). 11. Photodynamic therapy of cancer (K. Eszter Borbas and Dorothée
Lahaye). 12. Target-directed drug discovery (Tracey Bradshaw). 13. Tumour
hypoxia: a malignant mediator (Jill L. O'Donnell, Aoife M. Shannon, David
Bouchier-Hayes). 14. Resistance to chemotherapy drugs (Robert O?Connor and
Laura Breen). 15. Cancer immunotherapy (Maria Belimezi). 16. Gene therapy
(Maria Belimezi, Teni Boulikas and Michael L. Roberts). 17. Antisense
agents (Huma Khan and Sotiris Missailidis). 18. Aptamers as anticancer
agents (Vaidehi Makwana, Suzanne Simmons and Sotiris Missailidis). SECTION
III: OTHER ASPECTS IN ANTICANCER THERAPEUTIC DEVELOPMENT. 19. Treatment of
cancer in conjunction with other agents (Gary Robert Smith). 20. Clinical
trials in oncology (Tim Friede, Janet Dunn and Nigel Stallard). 21.
Representative cancers, treatment and market (Teni Boulikas). 22.
Conclusions and prospects (Sotiris Missailidis). 04707231063ENIntroduction.
1. Can Computer Games Affect Your Health? 2. Can Computer Games Change the
Way You Think? 3. Can Computer Games Change Who You Are? 4. Can Computer
Games Turn You Into an Addict? 5. Can Computer Games Make You Violent? 6.
Can Computer Games Change the Way You Learn? 7. Can Computer Games Change
Your Beliefs? 8. Can Computer Games Change Your Future? Index.