The Molecular Biology of Cancer (eBook, PDF)

A Bridge from Bench to Bedside
Redaktion: Pelengaris, Stella; Khan, Michael

• Format: PDF

Produktbeschreibung

This comprehensive text provides a detailed overview of the molecular mechanisms underpinning the development of cancer and its treatment. Written by an international panel of researchers, specialists and practitioners in the field, the text discusses all aspects of cancer biology from the causes, development and diagnosis through to the treatment of cancer. The text offers in-depth coverage of traditional areas of study, while also discussing areas of controversy and emerging importance and highlighting future directions for research.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 640
• Erscheinungstermin: 5. März 2013
• Englisch
• ISBN-13: 9781118430842
• Artikelnr.: 37747056

Autorenporträt

Stella Pelengaris Ph.D is Director of Pharmalogos and previous Researcher at the Imperial Cancer Research Fund, and Senior Research Fellow at the University of Warwick and Warwick Medical School. Mike Khan Ph.D FRCP is Associate Professor of Medicine at University Hospitals of Coventry and Warwickshire and previous Head of Molecular Medicine at the University of Warwick.

Inhaltsangabe

Contributors
vii Preface to the Second Edition
ix Reviews of the First Edition
x Acknowledgments and Dedication
xi About the Companion Website
xii Introduction
1 1 Overview of Cancer Biology
3 Michael Khan and Stella Pelengaris 2 The Burden of Cancer
43 William P. Steward and Anne L. Thomas 3 Nature and Nurture in Oncogenesis
67 Michael Khan and Stella Pelengaris 4 DNA Replication and the Cell Cycle
111 Stella Pelengaris and Michael Khan 5 Growth Signaling Pathways and the New Era of Targeted Treatment of Cancer
146 Stella Pelengaris and Michael Khan 6 Oncogenes
188 Stella Pelengaris and Michael Khan 7 Tumor Suppressors
239 Martine F. Roussel 8 Cell Death
266 Stella Pelengaris and Michael Khan 9 Senescence
Telomeres
and Cancer Stem Cells
295 Maria A. Blasco and Michael Khan 10 Genetic Instability
Chromosomes
and Repair
314 Michael Khan 11 There Is More to Cancer than Genetics: Regulation of Gene and Protein Expression by Epigenetic Factors
Small Regulatory RNAs
and Protein Stability
350 Stella Pelengaris and Michael Khan 12 Cell Adhesion in Cancer
383 Charles H. Streuli 13 Tumor Immunity and Immunotherapy
410 Cassian Yee 14 Tumor Angiogenesis
429 Christiana Ruhrberg 15 Cancer Chemistry: Designing New Drugs for Cancer Treatment
438 Ana M. Pizarro and Peter J. Sadler 16 Biologically Targeted Agents from Bench to Bedside
461 Michael Khan
Peter Sadler
Ana M. Pizarro
and Stella Pelengaris 17 The Diagnosis of Cancer
509 Anne L. Thomas
Bruno Morgan
and William P. Steward 18 Treatment of Cancer: Chemotherapy and Radiotherapy
526 Anne L. Thomas
J.P. Sage
and William P. Steward 19 Caring for the Cancer Patient
544 Nicky Rudd and Esther Waterhouse 20 Systems Biology of Cancer
554 Walter Schubert
Norbert C.J. de Wit
and Peter Walden Glossary
585 Answers to Questions
597 Index
603