Von Willebrand Disease (eBook, ePUB)

Basic and Clinical Aspects
Redaktion: Federici, Augusto B.; Montgomery, Robert R.; Lillicrap, David; Berntorp, Erik E.; Lee, Christine A.

• Format: ePub

Produktbeschreibung

Von Willebrand Disease: Basic and Clinical Aspects provides an insight into all aspects of the condition. Since its discovery, von Willebrand disease has been extensively studied and the causative factor deficiency, the understanding of the condition and its treatment has greatly improved. This book summarizes recent research and will help to optimize the management of patients with von Willebrand disease. This valuable book describes the important and complex role of von Willebrand factor in hemostasis and thrombosis. In addition to the current understanding of its molecular biology, this book gives particular focus to the association between genetic variants of von Willebrand factor and different von Willebrand disease phenotypes. It also reviews the important area of the obstetric and gynecological manifestations of von Willebrand disease, as well as the treatment of acute bleeding. Written by an international team of contributors it describes the progress in, and difficulties of diagnosing phenotypes and genotypes. Molecular diagnosis of type 1, type 2 and its subgroups, and type 3 von Willebrand disease are presented as well as discussion of the potential future role of gene therapy. Von Willebrand Disease: Basic and Clinical Aspects is a valuable resource for hematologists in practice and in training, and specialists in thrombosis and hemostasis.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 268
• Erscheinungstermin: 9. Januar 2011
• Englisch
• ISBN-13: 9781444329940
• Artikelnr.: 37350345

Autorenporträt

Augusto B. Federici, University of Milan, Milan, Italy Christine A. Lee, Oxford Haemophilia & Thrombosis Centre, Oxford, UK Erik E. Berntorp, Lund University, Malmö, Sweden David Lillicrap, Queen's University, Kingston, ON, Canada Robert R. Montgomery, Medical College of Wisconsin; Milwaukee, WI, USA

Inhaltsangabe

Contributors. Foreword. Preface. 1 Historical perspective on von Willebrand
disease (Erik Berntorp and Margareta Blombäck). 2 Biosynthesis and
organization of von Willebrand factor (Sandra L. Haberichter). 3 von
Willebrand factor structure and function (Robert R. Montgomery and Sandra
L. Haberichter). 4 Modulation of von Willebrand factor by ADAMTS13
(Jennifer Barr and David Motto). 5 Animal models in von Willebrand disease
(Cécile V. Denis, Olivier D. Christophe and Peter J. Lenting0. 6 Classifi
cation of von Willebrand disease (Javier Batlle, Almudena Pérez-Rodríguez
and María Fernanda López-Fernández). 7 The epidemiology of von Willebrand
disease (Giancarlo Castaman and Francesco Rodeghiero). 8 Clinical aspects
of von Willebrand disease: bleeding history (Paula D. James and Alberto
Tosetto). 9 Laboratory diagnosis of von Willebrand disease: the phenotype
(Ulrich Budde and Emmanuel J. Favaloro). 10 Molecular diagnosis of von
Willebrand disease: the genotype (Anne C. Goodeve and Reinhard
Schneppenheim). 11 Clinical, laboratory, and molecular markers of type 1
von Willebrand disease (David Lillicrap, Francesco Rodeghiero, and Ian
Peake). 12 Clinical, laboratory, and molecular markers of type 2 von
Willebrand disease (Dominique Meyer, Edith Fressinaud, and Claudine
Mazurier). 13 Clinical, laboratory, and molecular markers of type 3 von
Willebrand disease (Luciano Baronciani, Augusto B. Federici, and Jeroen
C.J. Eikenboom). 14 Pediatric aspects of von Willebrand disease (Jorge Di
Paola and Thomas Abshire). 15 Women with von Willebrand disease (Christine
A. Lee, Rezan A. Kadir, and Peter A. Kouides). 16 On the use of
desmopressin in von Willebrand disease (Stefan Lethagen, Augusto B.
Federici, and Giancarlo Castaman). 17 The use of plasma-derived
concentrates (Pier Mannuccio Mannucci and Massimo Franchini). 18
Prophylaxis in von Willebrand disease (Erik Berntorp). 19 Pathophysiology,
epidemiology, diagnosis, and treatment of acquired von Willebrand syndrome
(Ulrich Budde, Augusto B. Federici and Jacob H. Rand). 20 Gene therapy for
von Willebrand disease (Marinee K.L. Chuah, Inge Petrus, and Thierry
VandenDriessche). Index.