Overcoming Steroid Insensitivity in Respiratory Disease (eBook, PDF)

Redaktion: Adcock, Ian; Chung, Kian Fan

• Format: PDF

Produktbeschreibung

Written by well-known experts in field, this is the first book dedicated to dealing with the single most challenging management issue in long-term steroid therapy. Overcoming Steroid Insensitivity in Respiratory Disease reviews important new advances in therapeutics and provides the clinician with the most up to date information on one of the most significant therapeutic challenges to effective management of these diseases. This unique book is an invaluable resource for all postgraduate students and specialist physicians in pulmonology allergy and asthma. It is also of interest for workers in biomedical and pharmaceutical research.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 304
• Erscheinungstermin: 2. August 2008
• Englisch
• ISBN-13: 9780470985724
• Artikelnr.: 37301142

Autorenporträt

Ian Adcock, Professor of Respiratory Cell and Molecular Biology at the National Heart and Lung Institute, Royal Brompton Campus, ?London, UK. K Fan Chung, Professor, Experimental Studies Group, NHLI, Royal Brompton Campus, ?London, UK.

Inhaltsangabe

Contents List of contributors Preface 1 Molecular Mechanisms of
Glucocorticoid Receptor Action Pankaj Bhavsar and Ian M. Adcock 2 Side
Effects of Topical and Oral Glucocorticoids Heike Schäcke, Khusru Asadullah
and Wolf-Dietrich Döcke 3 Glucocorticoid Receptor Subtypes and Steroid
Sensitivity Robert H. Oakley and John A. Cidlowski 4 Dissociated
Glucocorticoids Ian M. Adcock 5 Generalized Glucocorticoid Insensitivity:
Clinical Phenotype and Molecular Mechanisms Evangelia Charmandari,
Tomoshige Kino and George P. Chrousos 6 Corticosteroid Responsiveness in
Asthma: Clinical Aspects Kian Fan Chung 7 Glucocorticoid-insensitive
Asthma: Molecular Mechanisms John W. Bloom 8 Cigarette Smoke, Oxidative
Stress and Corticosteroid Responsiveness Irfan Rahman and David Adenuga 9
Regulation of Glucocorticoid Sensitivity by Macrophage Migration Inhibitory
Factor Eric F. Morand 10 Steroid-sparing Strategies: Long-acting Inhaled ²2
-Agonists Anna Miller-Larsson and Olof Selroos 11 Steroid-sparing
Strategies: Other Combinations Gaetano Caramori, Kazuhiro Ito and Alberto
Papi 12 Kinases as Anti-inflammatory Targets for Respiratory Disease Iain
Kilty 13 Pharmacokinetic/Pharmacodynamic Factors and Steroid Sensitivity
Gönther Hochhaus 14 Improved Lung Deposition: New Inhaler Devices Omar S.
Usmani Index