Defining Optimal Immunotherapies for Type 1 Diabetes (eBook, PDF)

Redaktion: Bock, Gregory R.; Goode, Jamie A.

• Format: PDF

Produktbeschreibung

* This book is a comprehensive and up-to-date account of where we stand in immunological strategies for preventing or treating type 1 diabetes (T1D). * Brings together contributions from the leaders in the arena of clinical immunotherapy, not limited to the diabetes field exclusively, in order to delineate a road-map that would lead to future clinical trials. * The book integrates information from human and animal studies. * The book considers T1D within the broader context of autoimmune disease. * The format contains several discussions, which address specific questions and provides guidelines for future strategies and solutions for discovering a cure.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 222
• Erscheinungstermin: 14. September 2008
• Englisch
• ISBN-13: 9780470697412
• Artikelnr.: 37298679

Autorenporträt

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.

Inhaltsangabe

1. Michael Rutter Introduction: whither gene-environment interactions? 2.
Rudolf Uher Gene-environment interaction: overcoming methodological
challenges Discussion 3. Marco Battaglia, Cecilia Marino, Michel Maziade,
Massimo Molteni and Francesca D'Amato Gene-environment interaction and
behavioural disorders: a developmental perspective based on endophenotypes
Discussion 4. Naomi R. Wray, William L. Coventry, Michael R. James, Grant
W. Montgomery, Lindon J. Eaves and Nicholas G. Martin Use of monozygotic
twins to investigate the relationship between 5HTTLPR genotype, depression
and stressful life events: an application of Item Response Theory
Discussion Appendix General discussion I 5. Harold Snieder, Xiaoling Wang,
Vasiliki Lagou, Brenda W. J. H. Penninx, Harriëtte Riese and Catharina A.
Hartman Role of gene-stress interactions in gene-finding studies Discussion
6. Kenneth A. Dodge Practice and public policy in the era of
gene-environment interactions Discussion 7. Kristi B. Adamo and Frédérique
Tesson Gene-environment interaction and the metabolic syndrome Discussion
General discussion II 8. Stephen P. Robertson and Richie Poulton
Longitudinal studies of gene-environment interaction in common
diseases--good value for money? Discussion 9. Kee-Seng Chia
Gene-environment interactions in breast cancer Discussion 10. Malak Kotb,
Nourtan Abdeltawab, Ramy Aziz, Sarah Rowe, Robert W. Williams and Lu Lu
Unbiased forward genetics and systems biology approaches to understanding
how gene-environment interactions work to predict susceptibility and
outcomes of infections Discussion 11. Steven R. Kleeberger and Hye-Youn Cho
Gene-environment interactions in environmental lung diseases Discussion
General discussion III 12. Fernando D. Martinez Gene-environment
interaction in complex diseases: asthma as an illustrative case Discussion
13. Michael Rutter Conclusions: taking stock and looking ahead Glossary
Index of contributors Subject index