Nuclear Receptors in Drug Metabolism (eBook, PDF)

Redaktion: Xie, Wen

• Format: PDF

Produktbeschreibung

This book gives you an updated and expert overview of nuclear hormone receptors in drug metabolism and drug development and equips you with the interdisciplinary understanding of these receptors and how they can be regulated. Pharmaceutical researchers will find this extremely useful in developing drugs for cancer, heart disease, and diabetes treatment. This comprehensive resource collects scattered materials into one handy, informative volume.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 352
• Erscheinungstermin: 11. November 2008
• Englisch
• ISBN-13: 9780470409053
• Artikelnr.: 37292268

Autorenporträt

Wen Xie, MD, PHD, directs the Center for Pharmacogenetics at the University of Pittsburgh's School of Pharmacy. Among the courses he teaches are Pharmaceutical Analysis: Nucleic Acid Techniques; Pharmacogenomics: Pharmacogenetics of Drug Metabolizing Enzymes; and Drug Development. Dr. Xie is the author or coauthor of nearly seventy journal articles and more than seventy invited lectures.

Inhaltsangabe

Preface. Abbreviations. Contributors. Chapter 1. Drug Metabolism:
Significance and Challenges (Chandra Prakash and Alfin D.N. Vaz). Chapter
2. Establishing Orphan Nuclear Receptors PXR and CAR as Xenobiotic
Receptors (Tao Li, Junichiro Sonoda, and Ronald M. Evans). Chapter 3.
Nuclear Receptor-Mediated Regulation of Phase II Conjugating Enzymes
(Olivier Barbier). Chapter 4. Nuclear Receptor-Mediated Regulation of Drug
Transporters (Oliver Burk). Chapter 5. Structure and Function of PXR and
CAR (X. Edward Zhou and H. Eric Xu). Chapter 6. Xenobiotic Receptor
CoFactors and Coregulators (John Y. L. Chiang). Chapter 7. Animal Models of
Xenobiotic Nuclear Receptors and Their Utility in Drug Development (Haibiao
Gong and Wen Xie). Chapter 8. Nuclear Receptors and Drug-Drug Interactions
with Prescription Drugs and Herbal Medicines (Rommel G. Tirona and Richard
B. Kim). Chapter 9. Genetic Variants of Xenobiotic Receptors and Their
Implications in Drug Metabolism and Pharmacogenetics (Jatinder Lamba and
Erin G. Schuetz). Chapter 10. Beyond PXR and CAR, Regulation of Xenobiotic
Metabolism by Other Nuclear Receptors (Martin Wagner, Gernot Zollner, and
Michael Trauner). Chapter 11. Emerging Role of Retinoid-Related Orphan
Receptor (ROR) and Its Crosst alk With LXR(Liver X Receptor) in the
Regulation Of Drug-Metabolizing Enzymes (Taira Wada and Wen Xie). Index.