Evolutionary Biology (eBook, PDF)
Cell-Cell Communication, and Complex Disease
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Evolutionary Biology (eBook, PDF)
Cell-Cell Communication, and Complex Disease
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An integrative view of the evolution of genetics and the natural world Even in this advanced age of genomics, the evolutionary process of unicellular and multicellular organisms is continually in debate. Evolutionary Biology, Cell-Cell Communication, and Complex Disease challenges current wisdom by using physiology to present an integrative view of the nature, origins, and evolution of fundamental biological systems. Providing a deeper understanding of the way genes relate to the traits of living organisms, this book offers useful information applying evolutionary biology, functional genomics,…mehr
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- Produktdetails
- Verlag: John Wiley & Sons
- Seitenzahl: 176
- Erscheinungstermin: 15. März 2012
- Englisch
- ISBN-13: 9781118130421
- Artikelnr.: 37340574
- Verlag: John Wiley & Sons
- Seitenzahl: 176
- Erscheinungstermin: 15. März 2012
- Englisch
- ISBN-13: 9781118130421
- Artikelnr.: 37340574
The Origins of Unicellular Life on Earth 1 Prokaryotes versus Eukaryotes 4
Coevolution of traits 5 Cholesterol Facilitates Lipid Rafts for Cell-Cell
Communication 7 The Endomembrane System 9 The Cellular Mechanism of
Evolution 10 Why Evolve? 11 Cell-Cell Communication and Aging 12 2 REDUCING
LUNG PHYSIOLOGY TO ITS MOLECULAR PHENOTYPES 17 Hormonal Acceleration of
Lung Development 17 Neutral Lipid Traffi cking and Lung Evolution 19 Other
Examples of Cellular Cooperativity 23 Summary 24 3 A CELL-MOLECULAR
STRATEGY FOR SOLVING THE EVOLUTIONARY PUZZLE 25 Rationale for
Cell-Molecular Evolution 25 Mechanism of Mammalian Lung Development 28
Avian Lung Structure-Function Relationship: The Exception that Proves the
Rule 32 Does Ontogeny Recapitulate Phylogeny? The Role of PTHrP in Lung
Development 32 Interrelationship between PTHrP, Development, Physiology,
and Repair: Is Repair a Recapitulation of Ontogeny and Phylogeny? 33 4 THE
EVOLUTION OF CELL-CELL COMMUNICATION 35 Cell-Cell Communication as the
Mechanistic Basis for Evolutionary Biology 36 The Darwinian Biologic
Spacetime Continuum and Einstein's Vision of the Universe 37 Reverse
Engineering of Physiologic Traits as a Portal for Viewing Evolution 38
Cell-Cell Communication as the Basis for the Evolution of Metazoans 41
Understanding Lung Evolution from the Middle Out 42 The Cell-Cell
Communication Model of Lung Evolution Traces Contemporary Phenotypes Back
to Ancestral Phenotypes 43 Predictive Value of the Lung Cell-Cell
Communication Model for Understanding the Evolution of Physiologic Systems
44 Sexual Dimorphism of Lung Development: A Case Study in Cell-Cell
Communication and Evolutionary Plasticity 46 Androgen Affects the
Expression of Growth Factors Involved in Lung Development 48 Evidence for
an Association between Steroid-Resistant/Responsive Phenotypes and Human
Lymphocyte Antigen (HLA) Haplotypes 49 5 HOW TO INTEGRATE CELL-MOLECULAR
DEVELOPMENT, HOMEOSTASIS, ECOLOGY, AND EVOLUTIONARY BIOLOGY: THE MISSING
LINKS 53 Neutral Theory versus Intelligent Design 54 Internal Selection
Theory 54 The Counterintuitive Nature of Physiology and Solution to the
Dead Sea Scrolls Puzzle 57 The Continuum from Microevolution to
Macroevolution 58 cis Regulation and Adaptive Evolution 69 Evolution of cis
Regulatory Mechanisms 70 6 FROM CELL-CELL COMMUNICATION TO THE EVOLUTION OF
INTEGRATED PHYSIOLOGY 75 Cell-cell Signaling and Alveolar Development: A
Reductionist Approach to the Evolution of Physiologic Traits 77 An
Integrated, Empiric, Middle-Out Approach to Physiology 79 A Molecular
Evolutionary Link between the Lung and the Kidney? 82 The Berner Hypothesis
and Emergence of the Adipocyte: The Evolutionary Origins of the Lipofi
broblast 83 Lung Biology as a Cipher for Evolution 85 Do Stretch Effects on
PTHrP Expression Reflect Its Role in Adapting to Gravity? 85 Wolff's Law
Works for Both Bone and Lung 88 Functional Relationship between the
External and Internal Environments 89 An Evolutionary Vertical Integration
of the Phylogeny and Ontogeny of the Thyroid 91 7 EXPLOITING CELL-CELL
COMMUNICATION ACROSS SPACETIME TO DECONSTRUCT EVOLUTION 95 Somewhere
between the Gene and the Phenotype Lies the Process of Evolution 98 A
Functional Genomic Approach to Evolution as an Example of Terminal Addition
100 Seeking Deep Homologies in Lung Evolution 102 Systems Biology Based on
Cell-Cell Communication 105 Vertical Integration of Leptin Signaling, Human
Evolution, and the Trojan Horse Effect 108 Leptin and Human Evolution: Food
for Thought 109 8 THE PERIODIC TABLE OF BIOLOGY 115 The Prospect of a
Periodic Table of Biology 115 Cellular Cooperation Is Key 116 Elemental
Biology 118 PTHrP as an Archetype 118 Evolution as the Solution 119 Ramping
Up a Mathematical Model of Evolution 121 The Anthropic Principle Results
from the Evolution of Cell-Cell Interactions 124 9 VALUE ADDED BY THINKING
IN TERMS OF THE CELL-CELL COMMUNICATION MODEL FOR EVOLUTION 125 This is Not
a Just-So Story 126 Beyond Genomics 128 From Fat Cells to Integrated
Physiology 128 Molecular Homologies Distinguish between the Evolutionary
Forest and Trees 129 The Oxygen-Cholesterol-Surfactant-Membrane Connection
130 Cholesterol Metabolism as the Data Operating System for Vertebrate
Biology? 131 Translation of Genomics into the Periodic Table for Biology
132 Deep Homologies 134 Selection Pressure for Cell-Cell Communication: The
Key to Understanding Evolution 135 10 CELL-CELL COMMUNICATION AS THE BASIS
FOR PRACTICING CLINICAL MEDICINE 139 Cell-Cell Communication Maintenance
and Breakdown Represent Heath and Disease, Respectively 140 Cell-Cell
Communications as a Framework for Human Evolution 140 Canalization,
Decanalization, and the Holistic Approach to the Practice of Medicine 141
Exploiting Lung Evolution to Prevent and Treat Chronic Lung Disease 141
Lung Evolution Explains the Magic of Continuous Positive Airway Pressure
142 The Paradox of Infecting the Lung in Order to Treat Lung Disease Caused
by Infection 143 Exploiting Lung Evolution to Prevent and Treat
Smoking-Related Lung Damage 144 The Trojan Horse Effect of Canalization 145
Impetus for Evolutionary Science as an Integral Part of the Clinical
Curriculum 146 Application of Evolutionary Science to Bioethics 147
Evolutionary Science, a Biologic Periodic Table, and a Unifi ed Theory of
Biology 148 Summary 149 Name Index 151 Subject Index 153
The Origins of Unicellular Life on Earth 1 Prokaryotes versus Eukaryotes 4
Coevolution of traits 5 Cholesterol Facilitates Lipid Rafts for Cell-Cell
Communication 7 The Endomembrane System 9 The Cellular Mechanism of
Evolution 10 Why Evolve? 11 Cell-Cell Communication and Aging 12 2 REDUCING
LUNG PHYSIOLOGY TO ITS MOLECULAR PHENOTYPES 17 Hormonal Acceleration of
Lung Development 17 Neutral Lipid Traffi cking and Lung Evolution 19 Other
Examples of Cellular Cooperativity 23 Summary 24 3 A CELL-MOLECULAR
STRATEGY FOR SOLVING THE EVOLUTIONARY PUZZLE 25 Rationale for
Cell-Molecular Evolution 25 Mechanism of Mammalian Lung Development 28
Avian Lung Structure-Function Relationship: The Exception that Proves the
Rule 32 Does Ontogeny Recapitulate Phylogeny? The Role of PTHrP in Lung
Development 32 Interrelationship between PTHrP, Development, Physiology,
and Repair: Is Repair a Recapitulation of Ontogeny and Phylogeny? 33 4 THE
EVOLUTION OF CELL-CELL COMMUNICATION 35 Cell-Cell Communication as the
Mechanistic Basis for Evolutionary Biology 36 The Darwinian Biologic
Spacetime Continuum and Einstein's Vision of the Universe 37 Reverse
Engineering of Physiologic Traits as a Portal for Viewing Evolution 38
Cell-Cell Communication as the Basis for the Evolution of Metazoans 41
Understanding Lung Evolution from the Middle Out 42 The Cell-Cell
Communication Model of Lung Evolution Traces Contemporary Phenotypes Back
to Ancestral Phenotypes 43 Predictive Value of the Lung Cell-Cell
Communication Model for Understanding the Evolution of Physiologic Systems
44 Sexual Dimorphism of Lung Development: A Case Study in Cell-Cell
Communication and Evolutionary Plasticity 46 Androgen Affects the
Expression of Growth Factors Involved in Lung Development 48 Evidence for
an Association between Steroid-Resistant/Responsive Phenotypes and Human
Lymphocyte Antigen (HLA) Haplotypes 49 5 HOW TO INTEGRATE CELL-MOLECULAR
DEVELOPMENT, HOMEOSTASIS, ECOLOGY, AND EVOLUTIONARY BIOLOGY: THE MISSING
LINKS 53 Neutral Theory versus Intelligent Design 54 Internal Selection
Theory 54 The Counterintuitive Nature of Physiology and Solution to the
Dead Sea Scrolls Puzzle 57 The Continuum from Microevolution to
Macroevolution 58 cis Regulation and Adaptive Evolution 69 Evolution of cis
Regulatory Mechanisms 70 6 FROM CELL-CELL COMMUNICATION TO THE EVOLUTION OF
INTEGRATED PHYSIOLOGY 75 Cell-cell Signaling and Alveolar Development: A
Reductionist Approach to the Evolution of Physiologic Traits 77 An
Integrated, Empiric, Middle-Out Approach to Physiology 79 A Molecular
Evolutionary Link between the Lung and the Kidney? 82 The Berner Hypothesis
and Emergence of the Adipocyte: The Evolutionary Origins of the Lipofi
broblast 83 Lung Biology as a Cipher for Evolution 85 Do Stretch Effects on
PTHrP Expression Reflect Its Role in Adapting to Gravity? 85 Wolff's Law
Works for Both Bone and Lung 88 Functional Relationship between the
External and Internal Environments 89 An Evolutionary Vertical Integration
of the Phylogeny and Ontogeny of the Thyroid 91 7 EXPLOITING CELL-CELL
COMMUNICATION ACROSS SPACETIME TO DECONSTRUCT EVOLUTION 95 Somewhere
between the Gene and the Phenotype Lies the Process of Evolution 98 A
Functional Genomic Approach to Evolution as an Example of Terminal Addition
100 Seeking Deep Homologies in Lung Evolution 102 Systems Biology Based on
Cell-Cell Communication 105 Vertical Integration of Leptin Signaling, Human
Evolution, and the Trojan Horse Effect 108 Leptin and Human Evolution: Food
for Thought 109 8 THE PERIODIC TABLE OF BIOLOGY 115 The Prospect of a
Periodic Table of Biology 115 Cellular Cooperation Is Key 116 Elemental
Biology 118 PTHrP as an Archetype 118 Evolution as the Solution 119 Ramping
Up a Mathematical Model of Evolution 121 The Anthropic Principle Results
from the Evolution of Cell-Cell Interactions 124 9 VALUE ADDED BY THINKING
IN TERMS OF THE CELL-CELL COMMUNICATION MODEL FOR EVOLUTION 125 This is Not
a Just-So Story 126 Beyond Genomics 128 From Fat Cells to Integrated
Physiology 128 Molecular Homologies Distinguish between the Evolutionary
Forest and Trees 129 The Oxygen-Cholesterol-Surfactant-Membrane Connection
130 Cholesterol Metabolism as the Data Operating System for Vertebrate
Biology? 131 Translation of Genomics into the Periodic Table for Biology
132 Deep Homologies 134 Selection Pressure for Cell-Cell Communication: The
Key to Understanding Evolution 135 10 CELL-CELL COMMUNICATION AS THE BASIS
FOR PRACTICING CLINICAL MEDICINE 139 Cell-Cell Communication Maintenance
and Breakdown Represent Heath and Disease, Respectively 140 Cell-Cell
Communications as a Framework for Human Evolution 140 Canalization,
Decanalization, and the Holistic Approach to the Practice of Medicine 141
Exploiting Lung Evolution to Prevent and Treat Chronic Lung Disease 141
Lung Evolution Explains the Magic of Continuous Positive Airway Pressure
142 The Paradox of Infecting the Lung in Order to Treat Lung Disease Caused
by Infection 143 Exploiting Lung Evolution to Prevent and Treat
Smoking-Related Lung Damage 144 The Trojan Horse Effect of Canalization 145
Impetus for Evolutionary Science as an Integral Part of the Clinical
Curriculum 146 Application of Evolutionary Science to Bioethics 147
Evolutionary Science, a Biologic Periodic Table, and a Unifi ed Theory of
Biology 148 Summary 149 Name Index 151 Subject Index 153