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Drug Utilization Research (DUR) is an eclectic scientific discipline, integrating descriptive and analytical methods for the quantification, understanding and evaluation of the processes of prescribing, dispensing and consumption of medicines and for the testing of interventions to enhance the quality of these processes. The discipline is closely related and linked mainly to the broader field of pharmacoepidemiology, but also to health outcomes research, pharmacovigilance and health economics. Drug Utilization Research is a unique, practical guide to the assessment and evaluation of…mehr
Drug Utilization Research (DUR) is an eclectic scientific discipline, integrating descriptive and analytical methods for the quantification, understanding and evaluation of the processes of prescribing, dispensing and consumption of medicines and for the testing of interventions to enhance the quality of these processes. The discipline is closely related and linked mainly to the broader field of pharmacoepidemiology, but also to health outcomes research, pharmacovigilance and health economics. Drug Utilization Research is a unique, practical guide to the assessment and evaluation of prescribing practices and to interventions to improve the use of medicines in populations. Edited by an international expert team from the International Society for Pharmacoepidemiology (ISPE), DUR is the only title to cover both the methodology and applications of drug utilization research and covers areas such as health policy, specific populations, therapeutics and adherence.
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Monique Elseviers, Centre for Research and Innovation in Care, University of Antwerp, Belgium. Björn Wettermark, Associate Professor in Pharmacoepidemiology, Karolinska Institutet, Stockholm, Sweden. Morten Andersen, Visiting Professor, Centre for Pharmacoepidemiology, Karolinska Institutet, Stockholm, Sweden; Senior Physician at the Department of Clinical Pharmacology, Karolinska University Hospital, Stockholm, Sweden; Senior Researcher at the Research Unit for General Practice, University of Southern Denmark, Denmark. Ria Benko, Associate Professor, Department of Clinical Pharmacy at the University of Szeged, Hungary. Marion Bennie, Professor of Pharmacy Practice, University of Strathclyde, UK; Chief Pharmaceutical Adviser, NHS National Services Scotland, UK. Brian Godman, Research Scientist, Karolinska Institutet, Stockholm, Sweden. Janet Krska, Professor of Clinical and Professional Pharmacy, Medway School of Pharmacy, Universities of Greenwich and Kent, UK. Elisabetta Poluzzi, Assistant Professor of Pharmacology, Department of Pharmacology, Faculty of Medicine, University of Bologna, Italy. Katja Taxis, Associate Professor of Pharmacotherapy and Clinical Pharmacy, University of Groningen, Netherlands. Vera Vlahovic-Palcevski, Professor, Department of Pharmacology, University of Rijeka Medical School, Croatia; Specialist in Clinical Pharmacology, University Hospital Rijeka, Croatia. Robert Vander Stichele, practicing family physician in Ghent, Belgium.
Inhaltsangabe
List of contributors List of reviewers Acknowledgements About the companion website Part 1 -INTRODUCTION 1 INTRODUCTION TO DRUG UTILIZATION RESEARCH Björn Wettermark Monique Elseviers Anna Birna Almarsdóttir Morten Andersen Ria Benko Marion Bennie Irene Eriksson Brian Godman Janet Krska Elisabetta Poluzzi Katja Taxis Robert Vander Stichele Vera Vlahoviæ-Palèevski Part 2 -METHODOLOGY 2 STUDY DESIGNS IN DRUG UTILIZATION RESEARCH Björn Wettermark Mirko Di Martino Monique Elseviers 3 PRIMARY DATA COLLECTION FOR DRUG UTILIZATION RESEARCH Tatiana Chama Borges Luz Evalill Nilsson 4 SECONDARY DATA SOURCES FOR DRUG UTILIZATION RESEARCH Irene Eriksson Luisa Ibanez 5 CLASSIFICATION SYSTEMS FOR DRUGS AND DISEASES Marit Rønning Stuart McTaggart 6 MEASUREMENT UNITS OF DRUG UTILIZATION Hege Salvesen Blix 7 INDIVIDUAL LEVEL DRUG UTILIZATION ANALYSES Jesper Hallas Henrik Støvring Anton Pottegård 8 MEASUREMENT OF DRUG EXPENDITURE Sabine Vogler Jaana E. Martikainen 9 BASIC STATISTICAL METHODS IN DRUG UTILIZATION RESEARCH Douglas T Steinke Monique M Elseviers 10 VISUALIZATION OF DRUG UTILIZATION DATA Maria Matuz Ria Benko Mikael Hoffmann 11 MULTILEVEL ANALYSES IN DRUG UTILIZATION RESEARCH Juan Merlo 12 DEFINING AND DEVELOPING QUALITY INDICATORS FOR DRUG UTILIZATION Stephen Campbell Björn Wettermark Morten Andersen 13 QUALITATIVE METHODS IN DRUG UTILIZATION RESEARCH Anna Birna Almarsdóttir Pia Bastholm Rahmner Part 3 - APPLIED DRUG UTILIZATION RESEARCH Section A - COMPARATIVE DRUG UTILIZATION RESEARCH 14 COMPARISON OF DRUG UTILIZATION ACROSS DIFFERENT GEOGRAPHICAL AREAS Vera Vlahoviæ-Palèevski Björn Wettermark Luisa Ibanez Robert Vander Stichele 15 COMPARISON OF DRUG UTILIZATION IN DIFFERENT HEALTH CARE SETTINGS Sean MacBride-Stewart Ksenia Zagorodnikova Irene Langner Gisbert W Selke 16 TIME-DEPENDENT AND SEASONAL VARIATION IN DRUG UTILIZATION Eric Van Ganse Laurent Laforest Niels Adriaenssens 17 COMPARATIVE STUDIES ON PATIENT AND PRESCRIBER CHARACTERISTICS Irene Eriksson Ulf Bergman Vera Vlahoviæ-Palèevski Mia von Euler 18 COMPARATIVE STUDIES ON HEALTH SYSTEMS Tatiana Chama Borges Luz Claudia Osorio-de-Castro Björn Wettermark Section B - DRUG UTILIZATION AND HEALTH POLICY 19 INTRODUCTION TO DRUG UTILIZATION AND HEALTH POLICY Brian Godman Hye-Young Kwon Marion Bennie Anna Birna Almarsdóttir 20 MANAGED INTRODUCTION OF NEW DRUGS Brian Godman Roberta Joppi Marion Bennie Saira Jan Björn Wettermark 21 MANAGEMENT OF DRUGS IN THE HEALTH CARE SYSTEM Brian Godman Marion Bennie Claudia Osorio-de-Castro Vu Thi Thu Huong Saira Jan 22 PHARMACEUTICAL INDUSTRY AND HEALTH POLICY Richard Torbett Donald Han Indranil Bagchi Secion B - DRUG UTILIZATION IN SPECIFIC POPULATIONS 23 DRUG UTILIZATION IN PREGNANT WOMEN Hedvig Nordeng 24 DRUG UTILIZATION IN THE PAEDIATRIC POPULATION Antje Neubert Katja Taxis Ian Wong 25 DRUG UTILIZATION IN OLDER PEOPLE Katja Taxis David O'Sullivan Shane Cullinan Stephen Byrne Section C - DRUG UTILIZATION IN SPECIFIC THERAPEUTIC AREAS 26 DRUG UTILIZATION RESEARCH IN THE AREA OF ANTIBIOTICS Ria Benko Marion Bennie Samuel Coenen 27 DRUG UTILIZATION RESEARCH IN THE AREA OF CARDIOVASCULAR MEDICINES Elisabetta Poluzzi Maarit Jaana Korhonen 28 DRUG UTILIZATION RESEARCH IN THE AREA OF ANALGESICS AND PSYCHOTROPICS Helga Zoëga Alesha Smith Nadia Barozzi 29 DRUG UTILIZATION RESEARCH IN THE AREA OF BIOLOGICALS Carlo Piccinni Luigi Naldi Martin Neovius 30 DRUG UTILIZATION RESEARCH IN THE AREA OF CANCER DRUGS Nils Wilking Thomas Hofmarcher Ulla Wilking Bengt Jönsson Section D - DETERMINANTS OF DRUG UTILIZATION 31 HEALTH SYSTEM PERSPECTIVES Paul Spivey Brian Godman 32 PRESCRIBER PERSPECTIVES Colin Bradley Kathleen Holloway Janet Krska 33 PATIENT PERSPECTIVES Janine Traulsen Nicky Britten Janet Krska Section E - ADHERENCE AND DRUG UTILIZATION RESEARCH 34 AN INTRODUCTION TO ADHERENCE RESEARCH Bernard Vrijens 35 ASSESSMENT OF MEDICATION ADHERENCE IN FIELD RESEARCH Monique Elseviers Bernard Vrijens 36 ASSESSMENT OF ADHERENCE TO DRUG TREATMENT IN DATABASE RESEARCH Jean-Pierre Grégoire Jocelyne Moisan 37 INTERVENTIONS TO IMPROVE ADHERENCE TO DRUG TREATMENT Marie Paule Schneider Jennifer Celio Yoleen van Camp Matthias Cavassini Section F - THE ROLE OF DRUG UTILIZATION WITHIN THE FIELD OF PHARMACOEPIDEMIOLOGY 38 DRUG UTILIZATION RESEARCH AND RISK MANAGEMENT Giampiero Mazzaglia Peter Mol 39 DRUG UTILIZATION RESEARCH AND METHODS OF PHARMACOVIGILANCE Emanuel Raschi Fabrizio De Ponti 40 DRUG UTILIZATION RESEARCH AND THE REGULATOR'S PERSPECTIVE IN PHARMACOVIGILANCE Xavier Kurz Kevin Blake 41 DRUG UTILIZATION RESEARCH AND OUTCOME RESEARCH Henrik Toft Sørensen Gianluca Trifirò 42 DRUG UTILIZATION RESEARCH AND PHARMACOECONOMICS Cara Usher Kathleen Bennett Lorenzo G Mantovani Dyfrig Hughes Section G - ASSESSMENT AND IMPROVEMENT OF THE QUALITY OF MEDICINE USE 43 QUALITY INDICATORS FOR PRESCRIBING - WHAT DO WE MEASURE? Petra Denig Flora Haaijer-Ruskamp Lisa Pont 44 QUALITY INDICATORS FOR PATIENT CARE IN PHARMACY PRACTICE Hanne Herborg 45 INTERVENTIONS WHICH INFLUENCE PRESCRIBING DECISIONS AND DRUG UTILIZATION Jens Søndergaard Dorte Gilså Hansen Debra Rowett 46 DEVELOPMENT DELIVERY AND EVALUATION OF IMPLEMENTATION PROGRAMS Elizabeth Roughead Andrew Gilbert 47 TOWARDS BETTER UNDERSTANDING OF PRESCRIBING- ENHANCEMENT INTERVENTIONS Frank May Part 4 -EPILOGUE 48 THE MANY FUTURES OF DRUG UTILIZATION RESEARCH Hubert GM Leufkens Frank May Nicky Britten Glossary Index
List of contributors List of reviewers Acknowledgements About the companion website Part 1 -INTRODUCTION 1 INTRODUCTION TO DRUG UTILIZATION RESEARCH Björn Wettermark Monique Elseviers Anna Birna Almarsdóttir Morten Andersen Ria Benko Marion Bennie Irene Eriksson Brian Godman Janet Krska Elisabetta Poluzzi Katja Taxis Robert Vander Stichele Vera Vlahoviæ-Palèevski Part 2 -METHODOLOGY 2 STUDY DESIGNS IN DRUG UTILIZATION RESEARCH Björn Wettermark Mirko Di Martino Monique Elseviers 3 PRIMARY DATA COLLECTION FOR DRUG UTILIZATION RESEARCH Tatiana Chama Borges Luz Evalill Nilsson 4 SECONDARY DATA SOURCES FOR DRUG UTILIZATION RESEARCH Irene Eriksson Luisa Ibanez 5 CLASSIFICATION SYSTEMS FOR DRUGS AND DISEASES Marit Rønning Stuart McTaggart 6 MEASUREMENT UNITS OF DRUG UTILIZATION Hege Salvesen Blix 7 INDIVIDUAL LEVEL DRUG UTILIZATION ANALYSES Jesper Hallas Henrik Støvring Anton Pottegård 8 MEASUREMENT OF DRUG EXPENDITURE Sabine Vogler Jaana E. Martikainen 9 BASIC STATISTICAL METHODS IN DRUG UTILIZATION RESEARCH Douglas T Steinke Monique M Elseviers 10 VISUALIZATION OF DRUG UTILIZATION DATA Maria Matuz Ria Benko Mikael Hoffmann 11 MULTILEVEL ANALYSES IN DRUG UTILIZATION RESEARCH Juan Merlo 12 DEFINING AND DEVELOPING QUALITY INDICATORS FOR DRUG UTILIZATION Stephen Campbell Björn Wettermark Morten Andersen 13 QUALITATIVE METHODS IN DRUG UTILIZATION RESEARCH Anna Birna Almarsdóttir Pia Bastholm Rahmner Part 3 - APPLIED DRUG UTILIZATION RESEARCH Section A - COMPARATIVE DRUG UTILIZATION RESEARCH 14 COMPARISON OF DRUG UTILIZATION ACROSS DIFFERENT GEOGRAPHICAL AREAS Vera Vlahoviæ-Palèevski Björn Wettermark Luisa Ibanez Robert Vander Stichele 15 COMPARISON OF DRUG UTILIZATION IN DIFFERENT HEALTH CARE SETTINGS Sean MacBride-Stewart Ksenia Zagorodnikova Irene Langner Gisbert W Selke 16 TIME-DEPENDENT AND SEASONAL VARIATION IN DRUG UTILIZATION Eric Van Ganse Laurent Laforest Niels Adriaenssens 17 COMPARATIVE STUDIES ON PATIENT AND PRESCRIBER CHARACTERISTICS Irene Eriksson Ulf Bergman Vera Vlahoviæ-Palèevski Mia von Euler 18 COMPARATIVE STUDIES ON HEALTH SYSTEMS Tatiana Chama Borges Luz Claudia Osorio-de-Castro Björn Wettermark Section B - DRUG UTILIZATION AND HEALTH POLICY 19 INTRODUCTION TO DRUG UTILIZATION AND HEALTH POLICY Brian Godman Hye-Young Kwon Marion Bennie Anna Birna Almarsdóttir 20 MANAGED INTRODUCTION OF NEW DRUGS Brian Godman Roberta Joppi Marion Bennie Saira Jan Björn Wettermark 21 MANAGEMENT OF DRUGS IN THE HEALTH CARE SYSTEM Brian Godman Marion Bennie Claudia Osorio-de-Castro Vu Thi Thu Huong Saira Jan 22 PHARMACEUTICAL INDUSTRY AND HEALTH POLICY Richard Torbett Donald Han Indranil Bagchi Secion B - DRUG UTILIZATION IN SPECIFIC POPULATIONS 23 DRUG UTILIZATION IN PREGNANT WOMEN Hedvig Nordeng 24 DRUG UTILIZATION IN THE PAEDIATRIC POPULATION Antje Neubert Katja Taxis Ian Wong 25 DRUG UTILIZATION IN OLDER PEOPLE Katja Taxis David O'Sullivan Shane Cullinan Stephen Byrne Section C - DRUG UTILIZATION IN SPECIFIC THERAPEUTIC AREAS 26 DRUG UTILIZATION RESEARCH IN THE AREA OF ANTIBIOTICS Ria Benko Marion Bennie Samuel Coenen 27 DRUG UTILIZATION RESEARCH IN THE AREA OF CARDIOVASCULAR MEDICINES Elisabetta Poluzzi Maarit Jaana Korhonen 28 DRUG UTILIZATION RESEARCH IN THE AREA OF ANALGESICS AND PSYCHOTROPICS Helga Zoëga Alesha Smith Nadia Barozzi 29 DRUG UTILIZATION RESEARCH IN THE AREA OF BIOLOGICALS Carlo Piccinni Luigi Naldi Martin Neovius 30 DRUG UTILIZATION RESEARCH IN THE AREA OF CANCER DRUGS Nils Wilking Thomas Hofmarcher Ulla Wilking Bengt Jönsson Section D - DETERMINANTS OF DRUG UTILIZATION 31 HEALTH SYSTEM PERSPECTIVES Paul Spivey Brian Godman 32 PRESCRIBER PERSPECTIVES Colin Bradley Kathleen Holloway Janet Krska 33 PATIENT PERSPECTIVES Janine Traulsen Nicky Britten Janet Krska Section E - ADHERENCE AND DRUG UTILIZATION RESEARCH 34 AN INTRODUCTION TO ADHERENCE RESEARCH Bernard Vrijens 35 ASSESSMENT OF MEDICATION ADHERENCE IN FIELD RESEARCH Monique Elseviers Bernard Vrijens 36 ASSESSMENT OF ADHERENCE TO DRUG TREATMENT IN DATABASE RESEARCH Jean-Pierre Grégoire Jocelyne Moisan 37 INTERVENTIONS TO IMPROVE ADHERENCE TO DRUG TREATMENT Marie Paule Schneider Jennifer Celio Yoleen van Camp Matthias Cavassini Section F - THE ROLE OF DRUG UTILIZATION WITHIN THE FIELD OF PHARMACOEPIDEMIOLOGY 38 DRUG UTILIZATION RESEARCH AND RISK MANAGEMENT Giampiero Mazzaglia Peter Mol 39 DRUG UTILIZATION RESEARCH AND METHODS OF PHARMACOVIGILANCE Emanuel Raschi Fabrizio De Ponti 40 DRUG UTILIZATION RESEARCH AND THE REGULATOR'S PERSPECTIVE IN PHARMACOVIGILANCE Xavier Kurz Kevin Blake 41 DRUG UTILIZATION RESEARCH AND OUTCOME RESEARCH Henrik Toft Sørensen Gianluca Trifirò 42 DRUG UTILIZATION RESEARCH AND PHARMACOECONOMICS Cara Usher Kathleen Bennett Lorenzo G Mantovani Dyfrig Hughes Section G - ASSESSMENT AND IMPROVEMENT OF THE QUALITY OF MEDICINE USE 43 QUALITY INDICATORS FOR PRESCRIBING - WHAT DO WE MEASURE? Petra Denig Flora Haaijer-Ruskamp Lisa Pont 44 QUALITY INDICATORS FOR PATIENT CARE IN PHARMACY PRACTICE Hanne Herborg 45 INTERVENTIONS WHICH INFLUENCE PRESCRIBING DECISIONS AND DRUG UTILIZATION Jens Søndergaard Dorte Gilså Hansen Debra Rowett 46 DEVELOPMENT DELIVERY AND EVALUATION OF IMPLEMENTATION PROGRAMS Elizabeth Roughead Andrew Gilbert 47 TOWARDS BETTER UNDERSTANDING OF PRESCRIBING- ENHANCEMENT INTERVENTIONS Frank May Part 4 -EPILOGUE 48 THE MANY FUTURES OF DRUG UTILIZATION RESEARCH Hubert GM Leufkens Frank May Nicky Britten Glossary Index
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