Drug-Induced Mitochondrial Dysfunction (eBook, PDF)
Redaktion: Dykens, James A.; Will, Yvonne
Alle Infos zum eBook verschenken
Drug-Induced Mitochondrial Dysfunction (eBook, PDF)
Redaktion: Dykens, James A.; Will, Yvonne
- Format: PDF
- Merkliste
- Auf die Merkliste
- Bewerten Bewerten
- Teilen
- Produkt teilen
- Produkterinnerung
- Produkterinnerung
Hier können Sie sich einloggen
Bitte loggen Sie sich zunächst in Ihr Kundenkonto ein oder registrieren Sie sich bei bücher.de, um das eBook-Abo tolino select nutzen zu können.
This is the definitive, one-stop resource on preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue upfront in the drug development process. It discusses mitochondrial impairment to organs, skeletal muscle, and nervous systems and details methodologies used to assess mitochondria function. It covers both in vitro and in vivo methods for analysis and includes the latest models. This is the authoritative reference on drug-induced mitochondrial dysfunction for safety assessment professionals in the pharmaceutical industry and for pharmacologists and toxicologists in both drug and environmental health sciences.…mehr
- Geräte: PC
- mit Kopierschutz
- eBook Hilfe
- Größe: 13.22MB
- Early Drug Development (eBook, PDF)162,99 €
- Evaluation of Drug Candidates for Preclinical Development (eBook, PDF)112,99 €
- Binghe WangDrug-Drug Interactions in Pharmaceutical Development (eBook, PDF)101,99 €
- Predictive Approaches in Drug Discovery and Development (eBook, PDF)132,99 €
- Pharmaceutical Toxicology in Practice (eBook, PDF)107,99 €
- Pharmacometrics (eBook, PDF)220,99 €
- Molecular Pathology in Drug Discovery and Development (eBook, PDF)131,99 €
-
-
-
Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.
- Produktdetails
- Verlag: John Wiley & Sons
- Seitenzahl: 652
- Erscheinungstermin: 12. September 2008
- Englisch
- ISBN-13: 9780470372524
- Artikelnr.: 37291743
- Verlag: John Wiley & Sons
- Seitenzahl: 652
- Erscheinungstermin: 12. September 2008
- Englisch
- ISBN-13: 9780470372524
- Artikelnr.: 37291743
Physiology in Cell Viability and Death (Lech Wojtczak and Krzysztof
Zabtocki). 2. Basic Molecular Biology of Mitochondrial Replication (Immo E.
Scheffler). 3. Drug-Associated Mitochondrial Toxicity (Rhea Mehta, Katie
Chan, Owen Lee, Shahrzad Tafazoli, and Peter J. O'Brien). 4.
Pharmacogenetics of Mitochondrial Drug Toxicity (Neil Howell and Corinna
Howell). Part II: Organ Drug Toxicity: Mitochondrial Etiology. 5. Features
and Mechanisms of Drug-Induced Liver Injury (Dominique Pessayre, Alain
Berson, and Bernard Fromenty). 6. Cardiovascular Toxicity of Mitochondrial
Origin (Paulo J. Oliveira, Vilma A. Saradao, and Kendall B. Wallace). 7.
Skeletal Muscle and Mitochondrial toxicity (Timothy E. Johnson). 8.
Manifestations of Drug Toxicity on Mitochondria in the Nervous System (Ian
J. Reynolds). 9. Lipoatrophy and Other Manifestations of Antiretroviral
Therapeutics (Ulrich A. Walker). 10. Nephrotoxocity (Alberto Ortiz, Alberto
Tejedor, and Carlos Caramelo). 11. Drug Effects in Patients with
Mitochondrial Diseases (Eric A. Schon, Michio Hirano, and Salvatore
DiMauro). Part III: Assessment of Mitochondrial Function in Vitro and In
Vivo. 12. Polarographic Oxygen Sensors, the Oxygraph, and High-Resolution
Respirometry to Assess Mitochondrial Function (Erich Gnaiger). 13. Use of
Oxygen-Sensitive Fluorescent Probes for the Assesment of Mitochondrial
Function (James Hynes, Tomas C. O'riordan, and Dmitri B. Papkovsky). 14.
Mitochondrial Dysfunction Assessed Quantitatively in Real Time by Measuring
the Extracellular Flux of Oxygen and Protons (David Ferrick, Min Wu, Amy
Swift, and Andy Neilson). 15. Assessment of Mitochondrial Respiratory
Complex Function In Vitro and In Vivo (Mark A. Birch -Machin). 16. OXPHOS
Complex Activity Assays and Dipstick Immunoassays for Assessment of OXPHOS
Protein Levels (Sashi Nadanaciva). 17. Use of Fluorescent Reporters to
Measure Mitochondrial Membrane Potential and the Mitochondrial Permeability
Transition (Anna Liisa Nieminen, Benkat K. Ramshesh, and John L.
Lemasters). 18. Compartmentation of Redox Signaling and Control:
Discrimination of Oxidative Stress in Mitochondria, Cytoplasm, Nuclei, and
endoplasmic Reticulum (Patrick J. Halvey, Jason M. Hansen, Lawrence H.
Lash, and Dean P. Hones). 19. Assessing Mitochondrial Protein Synthesis in
Drug Toxicity Screening (Edward E. McKee). 20. Mitochondrial Toxicity of
Antiviral Drugs: A Challenge to Accurate Diagnosis (Michel P. de Baar and
Anthony de Ronde). 21. Clinical Assessment of Mitochondrial Function via
[13C]Methionine Exhalation (Laura Milazzo). 22. Assessment of Mitochondrial
Dysfunction by Microscopy (Ingrid Pruimboom-Brees, Germaine Boucher, Amy
Jakowski, and Jeanne Wolfgang). 23. Development of Animal Models of
Drug-Induced Mitochondrial Toxicity (Urs A. Boelsterli and Yie Hou Lee).
24. Noninvasive Assessment of Mitochondrial Function Using Nuclear Magnetic
Resonance Spectroscopy (Robert W. Wiseman and J.A. L. Jeneson). 25.
Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations
(Michael P. Murphy). Index.
Physiology in Cell Viability and Death (Lech Wojtczak and Krzysztof
Zabtocki). 2. Basic Molecular Biology of Mitochondrial Replication (Immo E.
Scheffler). 3. Drug-Associated Mitochondrial Toxicity (Rhea Mehta, Katie
Chan, Owen Lee, Shahrzad Tafazoli, and Peter J. O'Brien). 4.
Pharmacogenetics of Mitochondrial Drug Toxicity (Neil Howell and Corinna
Howell). Part II: Organ Drug Toxicity: Mitochondrial Etiology. 5. Features
and Mechanisms of Drug-Induced Liver Injury (Dominique Pessayre, Alain
Berson, and Bernard Fromenty). 6. Cardiovascular Toxicity of Mitochondrial
Origin (Paulo J. Oliveira, Vilma A. Saradao, and Kendall B. Wallace). 7.
Skeletal Muscle and Mitochondrial toxicity (Timothy E. Johnson). 8.
Manifestations of Drug Toxicity on Mitochondria in the Nervous System (Ian
J. Reynolds). 9. Lipoatrophy and Other Manifestations of Antiretroviral
Therapeutics (Ulrich A. Walker). 10. Nephrotoxocity (Alberto Ortiz, Alberto
Tejedor, and Carlos Caramelo). 11. Drug Effects in Patients with
Mitochondrial Diseases (Eric A. Schon, Michio Hirano, and Salvatore
DiMauro). Part III: Assessment of Mitochondrial Function in Vitro and In
Vivo. 12. Polarographic Oxygen Sensors, the Oxygraph, and High-Resolution
Respirometry to Assess Mitochondrial Function (Erich Gnaiger). 13. Use of
Oxygen-Sensitive Fluorescent Probes for the Assesment of Mitochondrial
Function (James Hynes, Tomas C. O'riordan, and Dmitri B. Papkovsky). 14.
Mitochondrial Dysfunction Assessed Quantitatively in Real Time by Measuring
the Extracellular Flux of Oxygen and Protons (David Ferrick, Min Wu, Amy
Swift, and Andy Neilson). 15. Assessment of Mitochondrial Respiratory
Complex Function In Vitro and In Vivo (Mark A. Birch -Machin). 16. OXPHOS
Complex Activity Assays and Dipstick Immunoassays for Assessment of OXPHOS
Protein Levels (Sashi Nadanaciva). 17. Use of Fluorescent Reporters to
Measure Mitochondrial Membrane Potential and the Mitochondrial Permeability
Transition (Anna Liisa Nieminen, Benkat K. Ramshesh, and John L.
Lemasters). 18. Compartmentation of Redox Signaling and Control:
Discrimination of Oxidative Stress in Mitochondria, Cytoplasm, Nuclei, and
endoplasmic Reticulum (Patrick J. Halvey, Jason M. Hansen, Lawrence H.
Lash, and Dean P. Hones). 19. Assessing Mitochondrial Protein Synthesis in
Drug Toxicity Screening (Edward E. McKee). 20. Mitochondrial Toxicity of
Antiviral Drugs: A Challenge to Accurate Diagnosis (Michel P. de Baar and
Anthony de Ronde). 21. Clinical Assessment of Mitochondrial Function via
[13C]Methionine Exhalation (Laura Milazzo). 22. Assessment of Mitochondrial
Dysfunction by Microscopy (Ingrid Pruimboom-Brees, Germaine Boucher, Amy
Jakowski, and Jeanne Wolfgang). 23. Development of Animal Models of
Drug-Induced Mitochondrial Toxicity (Urs A. Boelsterli and Yie Hou Lee).
24. Noninvasive Assessment of Mitochondrial Function Using Nuclear Magnetic
Resonance Spectroscopy (Robert W. Wiseman and J.A. L. Jeneson). 25.
Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations
(Michael P. Murphy). Index.