Chemokine Receptors and NeuroAIDS (eBook, PDF)

Beyond Co-Receptor Function and Links to Other Neuropathologies
Redaktion: Meucci, Olimpia

• Format: PDF

Produktbeschreibung

Chemokines and their receptors are being recognized as an integral component of the nervous system implicated in fundamental aspects of development and homeostasis, such as neurotransmission, proliferation, differentiation, and neuronal-glial communication. Thus, their involvement in HIV neuropathology goes far beyond the co-receptors role and entails complex interactions of the chemokine system with different cell types and other regulators of neuronal function. The major goal of this volume is to review these topics in order to highlight alterations of chemokine physiology that may contribute to neuroAIDS and other neuropathologies.

This book will be of interest to neuroscientists, neurologists, virologists, pharmacologists, and students in these fields.

About the Editor:

Olimpia Meucci, MD, PhD is a Professor of Pharmacology and Physiology & Microbiology and Immunology at Drexel University College of Medicine in Philadelphia, PA. Since her seminal discovery about the regulation of neuronal signaling by chemokines, her research has primarily focused on the physio-pathological roles of this important class of neuroimmune modulators in the central nervous system and their involvement in neuroAIDS. These studies have significantly contributed to current understanding of the cellular and molecular mechanisms of HIV-related neuropathology including the interaction of the chemokine system with drug of abuse, namely opiates, which continues to be a major area of investigation in the Meucci lab.

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Produktdetails

• Verlag: Springer-Verlag GmbH
• Seitenzahl: 412
• Erscheinungstermin: 2. Dezember 2009
• Englisch
• ISBN-13: 9781441907936
• Artikelnr.: 37350295

Autorenporträt

About the Editor: Olimpia Meucci, MD, PhD is a Professor of Pharmacology and Physiology & Microbiology and Immunology at Drexel University College of Medicine in Philadelphia, PA. Since her seminal discovery about the regulation of neuronal signaling by chemokines, her research has primarily focused on the physio-pathological roles of this important class of neuroimmune modulators in the central nervous system and their involvement in neuroAIDS. These studies have significantly contributed to current understanding of the cellular and molecular mechanisms of HIV-related neuropathology including the interaction of the chemokine system with drug of abuse, namely opiates, which continues to be a major area of investigation in the Meucci lab.

Inhaltsangabe

Chemokine receptors as HIV coreceptors: the brain perspective.- HIV neurotropisms: lessons from the developing world.- CCR5 and CXCR4: different roles at different times.- Co-receptors signaling in neurons.- Roles of monocytes and microglia.- Regulation of glutamate release and uptake: CXCR4 and glia.- CX3CR1, glutamatergic neurotransmission and excitotoxicity.- Chemokines cleavage products in HIVE.- Expression and function of chemokine receptors in neural progenitors.- CXCR4 in neuronal migration and differentiation.- Altered expression of cell cycle proteins in HIVE.- E2F1 and downstream targets in HIV neuropathology.- Regulation of the Rb protein by CXCR4 in differentiated neurons.- Opiates and HIV.- Interaction between opioid and chemokine receptors in immune cells: implications to HIV infection.- Regulation of neuronal CXCR4 by µ-opioid receptors.- Opioids, chemokines and glial.- Opioids regulation of the immune response: what is relevant to HIV.- Chemokines and Alzheimer's.- Chemokines and brain cancer.- Index.