Chemokine Receptors and NeuroAIDS

Beyond Co-Receptor Function and Links to Other Neuropathologies
Herausgegeben:Meucci, Olimpia

• Gebundenes Buch

Produktbeschreibung

Chemokine Receptors and NeuroAIDS: Beyond the Co-receptor Function and Links to Other Neuropathologies focuses on unresolved or emerging issues concerning the role of chemokine receptors in neuronal injury and HIV neuropathology, including their ability to regulate fundamental neuronal and glial functions and their role in neurovirulence and neurotoxicity. Although the importance of these molecules in the CNS physiology and pathology is now apparent, these issues are still matter of debate, and further research is required to design effective pharmacological agents that specifically target the brain chemokine system without major side effects.

To this end, specific topics have been selected and are reviewed by international experts within the basic science/medical community. This book encourages investigation in the most controversial areas and fosters interaction between clinicians and basic scientists. The book also increases awareness about differences in disease progression among different parts of the world as well as selected patient populations, which may also help identifying novel therapeutic strategies.

Produktdetails

• Verlag: Springer / Springer New York / Springer, Berlin
• Artikelnr. des Verlages: 12217618, 978-1-4419-0792-9
• 2010
• Seitenzahl: 428
• Erscheinungstermin: 24. Dezember 2009
• Englisch
• Abmessung: 241mm x 160mm x 31mm
• Gewicht: 844g
• ISBN-13: 9781441907929
• ISBN-10: 1441907920
• Artikelnr.: 26244343

Autorenporträt

About the Editor: Olimpia Meucci, MD, PhD is a Professor of Pharmacology and Physiology & Microbiology and Immunology at Drexel University College of Medicine in Philadelphia, PA. Since her seminal discovery about the regulation of neuronal signaling by chemokines, her research has primarily focused on the physio-pathological roles of this important class of neuroimmune modulators in the central nervous system and their involvement in neuroAIDS. These studies have significantly contributed to current understanding of the cellular and molecular mechanisms of HIV-related neuropathology including the interaction of the chemokine system with drug of abuse, namely opiates, which continues to be a major area of investigation in the Meucci lab.

Inhaltsangabe

Chemokine receptors as HIV coreceptors: the brain perspective.- HIV neurotropisms: lessons from the developing world.- CCR5 and CXCR4: different roles at different times.- Co-receptors signaling in neurons.- Roles of monocytes and microglia.- Regulation of glutamate release and uptake: CXCR4 and glia.- CX3CR1, glutamatergic neurotransmission and excitotoxicity.- Chemokines cleavage products in HIVE.- Expression and function of chemokine receptors in neural progenitors.- CXCR4 in neuronal migration and differentiation.- Altered expression of cell cycle proteins in HIVE.- E2F1 and downstream targets in HIV neuropathology.- Regulation of the Rb protein by CXCR4 in differentiated neurons.- Opiates and HIV.- Interaction between opioid and chemokine receptors in immune cells: implications to HIV infection.- Regulation of neuronal CXCR4 by µ-opioid receptors.- Opioids, chemokines and glial.- Opioids regulation of the immune response: what is relevant to HIV.- Chemokines and Alzheimer's.- Chemokines and brain cancer.- Index.