Surendra Nimesh, Ramesh Chandra, Nidhi Gupta

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids (eBook, ePUB)

• Format: ePub

Produktbeschreibung

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance.

The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc.

• Provides a complete overview of the applicatiosn of nanomedicine in the delivery of nucleic acids, from characterization of nanoparticles, to in vitro and in vivo studies
• Discusses delivery issues of less well explored nucleic acids, like PNAs, Ribozymes, DNAzymes, etc.
• Summarizes the current state of research in nucleic acid delivery and underscores the future of nanomedicine in this field

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 256
• Erscheinungstermin: 4. April 2017
• Englisch
• ISBN-13: 9780081005637
• Artikelnr.: 47995761

Autorenporträt

Dr. Surendra Nimesh did PhD in nanotechnology from Dr. B.R. Ambedkar Center for Biomedical Science Research, University of Delhi and CSIR-Institute of Genomics and Integrative Biology, Delhi, India. He did postdoctorate at Ecole Polytechnique of Montreal, Montreal; Clinical Research Institute of Montreal, Montreal and Health Canada, Ottawa, Canada. He has published several research and review articles and authored/coauthored seven books that includes two Elsevier books: The Design and Development of Novel Drugs and Vaccines (2021) and Gene Therapy: Potential Applications of Nanotechnology (2013). He is an internationally recognized expert of nanotechnology for biological applications with specialization in drug and gene delivery.
Dr. Nidhi Gupta received PhD degree in virology from the National Institute of Immunology and Jawaharlal Nehru University, New Delhi, India. She did doctoral research at Clinical Research Institute of Montreal, Montreal, and McGill University, Montreal, Canada. She has several research and review articles to her credit along with three authored/coauthored books. Her field of interest includes catalytic nucleic acids, siRNA, antisense, and nanomedicine.

Inhaltsangabe

1. Nanomedicine for delivery of therapeutic molecules 2. Nanoparticles as nucleic acid delivery vectors 3. Methods for characterization of nanoparticles 4. Nanoparticles for DNA delivery 5. Nanoparticles for siRNA-mediated gene silencing 6. Nanoparticles for locked nucleic acid delivery 7. Nanoparticles for ribozymes delivery 8. Nanoparticles for DNAzymes delivery 9. Pharmacokinetics and biodistribution of the nanoparticles 10. Nanotoxicology: Evaluation of toxicity potential of nanoparticles 11. Regulatory aspects of nanoparticulate mediated nucleic acid delivery systems 12. Clinical studies and future prospects