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Global warming is carried forward by human endosymbiotic archaeal overgrowth and methanogenesis. The archaea can induce stem cell conversion and neanderthalisation of the human species. The archaea catabolizes cholesterol generating digoxin which can modulate RNA editing and magnesium deficiency resulting in reverse transcriptase inhibition. The archaeal cholesterol catabolism can deplete the membrane rafts of the CD4 cell of cholesterol impeding the entry of the retrovirus into the cell. The archaea can produce permanent immune activation producing resistance to viral and bacterial infection. The archaeal cholesterol catabolism depletes tissue cholesterol producing vitamin D deficiency and immune activation. Thus archaeal overgrowth results in retroviral resistance and generation of the Neanderthal phenotype. The homo sapiens do not have the Neanderthal mechanisms of immune activation as their archaeal load is meagre. They serve as fodder for infection from Neanderthal generatedviruses and bacteria and suffer eventual extinction.