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Diabetes mellitus is a disease in the glucose-insulin
endocrine metabolic regulatory system, in which the
pancreas either does not release insulin or does not
properly use insulin to uptake glucose in the plasma,
which is referred as hyperglycemia. Complications of
diabetes mellitus include retinopathy, nephropathy,
peripheral neuropathy and blindness. The purpose of
this study is to model the dynamic of the short-term
glucose regulatory system (GRS) in man and its
hormonal regulation by considering all the feedback
loops which are responsible of controlling the
glucose metabolism in man. The model proposed in this
work used the system dynamics (SD) approach which was
designed for studying complex systems. This SD model
consists of twenty-three negative (balance) loops and
six compartments. The model was validated during wide
range of clinical test inputs, to be sure that this
model accurately represents the really endocrine
system. Understanding the mechanism underlying
glucose-insulin oscillations and determination of the
origin of the glucose insulin levels oscillations is
another purpose of this model.
Other applications for this model also have been
explored.
endocrine metabolic regulatory system, in which the
pancreas either does not release insulin or does not
properly use insulin to uptake glucose in the plasma,
which is referred as hyperglycemia. Complications of
diabetes mellitus include retinopathy, nephropathy,
peripheral neuropathy and blindness. The purpose of
this study is to model the dynamic of the short-term
glucose regulatory system (GRS) in man and its
hormonal regulation by considering all the feedback
loops which are responsible of controlling the
glucose metabolism in man. The model proposed in this
work used the system dynamics (SD) approach which was
designed for studying complex systems. This SD model
consists of twenty-three negative (balance) loops and
six compartments. The model was validated during wide
range of clinical test inputs, to be sure that this
model accurately represents the really endocrine
system. Understanding the mechanism underlying
glucose-insulin oscillations and determination of the
origin of the glucose insulin levels oscillations is
another purpose of this model.
Other applications for this model also have been
explored.