Systematic review and meta-analysis of the relationship between BDNF and MDD

Systematic review and meta-analysis of the relationship between BDNF and MDD

A search for biomarkers for the prognosis or diagnosis of major depressive disorder

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Depression is a multifactorial illness that, according to the World Health Organisation, affects more than 300 million people worldwide. It is highly incapacitating and in its worst case scenario leads to suicide and death. The pathophysiology of depressive disorder has a number of theories such as mono aminergic, inflammatory and neurotrophin. This work is based on the latter, more precisely on one of the neurotrophins, brain-derived neurotrophic factor (BDNF). BDNF in its mature form acts on Trkbeta receptors, promoting neuronal survival, long- and short-term potentiation and hippocampal neu...