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In the present study we have reported the synthesis of some new tamoxifen analogues comprising triphenylethylene core moiety which is the pharmacophoric requirement for estrogen receptor to act as anticancer agent by selective estrogen receptor modulation (SERM). Tamoxifen used for both purpose prevention and treatment of estrogen positive breast cancer. According to these knowledges we designed and synthesized new tamoxifen analogues as potential anticancer agents. New tamoxifen analogues contain triphenylethylene skeleton which is connected to 1,3,4-thiadiazole. Most of literature we found 1,3,4-thiadiazole showed good anticancer activity. To know the best structural requirement, we studied docking in which we found high docking score and similar kind of interaction for our designed tamoxifen analogues as compare to tamoxifen.