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This Special Issue aims to assemble the latest perspectives and research findings to illuminate the role of altered sympathetic nerve activity (SNA) in cardiovascular disease (CVD) pathogenesis. It comprises one editorial article, five review articles, and six original research articles, which collectively emphasize the significance of SNA in the pathogenesis of various CVDs, including hypertension, atherosclerosis, heart failure, peripheral artery disease, diabetic wound healing, and chronic pain-associated CVDs.