Structural, Metabolic Efficiency and Functional Monitoring

Structural, Metabolic Efficiency and Functional Monitoring

of the Cerebellum and Basal Ganglia during Aging

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Our understanding of the mechanisms responsible for decline of human mental capabilities which accompany aging became one of the major concerns of modern gerontology. Our understanding of their structure, organization, function and implication in diseases and age-related changes has increased equally. The most recent global analysis of the pathogenesis of aging process of BG and cerebellum at the molecular level suggested that aging resulted in a gene expression profile indicative of an inflammatory response, oxidative stress, alteration in mitochondrial DNA, loss of homeostasis (dynamic equil...