A comprehensive and authoritative compilation of up-to-date developments in stem cell research and its use in toxicology and medicine _ Presented by internationally recognized investigators in this exciting field of scientific research _ Provides an insight into the current trends and future directions of research in this rapidly developing new field _ A valuable and excellent source of authoritative and up-to-date information for researchers, toxicologists, drug industry, risk assessors and regulators in academia, industry and government
A comprehensive and authoritative compilation of up-to-date developments in stem cell research and its use in toxicology and medicine _ Presented by internationally recognized investigators in this exciting field of scientific research _ Provides an insight into the current trends and future directions of research in this rapidly developing new field _ A valuable and excellent source of authoritative and up-to-date information for researchers, toxicologists, drug industry, risk assessors and regulators in academia, industry and government
Dr. Saura C. Sahu Research Chemist, Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration. Dr. Sahu is the US Editor for the Journal of Applied Toxicology and the editor of "Hepatotoxicity" (Wiley, 2007), "Toxicogenomics" (Wiley, 2008), "Nanotoxicity" (Wiley, 2009), and "Handbook of Systems Toxicology" (Wiley, 2011).
Inhaltsangabe
List of Contributors xx
Preface xxvi
Acknowledgements xxvii
PART I 1
1 Introduction 3 Saura C. Sahu
References 4
2 Application of Stem Cells and iPS Cells in Toxicology 5 Maria Virginia Caballero, Ramon A. Espinoza-Lewis, and Manila Candiracci
2.1 Introduction 5
2.2 Significance 6
2.3 Stem Cell (SC) Classification 7
2.4 Stem Cells and Pharmacotoxicological Screenings 8
2.5 Industrial Utilization Showcases Stem Cell Technology as a Research Tool 8
2.6 Multipotent Stem Cells (Adult Stem Cells) Characteristics and Current Uses 9
3 Stem Cells: A Potential Source for High Throughput Screening in Toxicology 26 Harish K Handral, Gopu Sriram, and Tong Cao
3.1 Introduction 26
3.2 Stem Cells 27
3.3 High Throughput Screening (HTS) 31
3.4 Need for a Stem Cell Approach in High Throughput Toxicity Studies 37
3.5 Role of Stem Cells in High Throughput Screening for Toxicity Prediction 38
3.6 Conclusion 40
Acknowledgement 41
Disclosure Statement 41
Author's Contribution 41
References 41
4 Human Pluripotent Stem Cells for Toxicological Screening 50 Lili Du and Dunjin Chen
4.1 Introduction 50
4.2 The Biological Characteristics of hPSCs 51
4.3 Screening of Embryotoxic Effects using hPSCs 52
4.4 The Potential of hPSC-Derived Neural Lineages in Neurotoxicology 55
4.5 The Potential of hPSC -Derived Cardiomyocytes in Cardiotoxicity 60
4.6 The Potential of hPSC-Derived Hepatocytes in Hepatotoxicity 62
4.7 Future Challenges and Perspectives for Embryotoxicity and Developmental Toxicity Studies using hPSCs 65
Acknowledgments 66
References 67
5 Effects of Culture Conditions on Maturation of Stem Cell-Derived Cardiomyocytes 71 Deborah K. Hansen, Amy L. Inselman, and Xi Yang
5.1 Introduction 71
5.2 Lengthening Culture Time 75
5.3 Substrate Stiffness 76
5.4 Structured Substrates 78
5.5 Conclusions 82
Disclaimer 82
References 83
6 Human Stem Cell-Derived Cardiomyocyte In Vitro Models for Cardiotoxicity Screening 85 Tracy Walker, Kate Harris, Evie Maifoshie, and Khuram Chaudhary
6.1 Introduction 85
6.2 Overview of hPSC-Derived Cardiomyocytes 88
6.3 Human PSC-CM Models for Cardiotoxicity Investigations 90
6.4 Conclusions and Future Direction 112
References 112
7 Disease-Specific Stem Cell Models for Toxicological Screenings and Drug Development 122 Matthias Jung, Juliane-Susanne Jung, Jovita Schiller, and Insa S. Schroeder
7.1 Evidence for Stem Cell-Based Drug Development and Toxicological Screenings in Psychiatric Diseases, Cardiovascular Diseases and Diabetes 122
7.2 Disease-Specific Stem Cell Models for Drug Development in Psychiatric Disorders 127
7.3 Stem Cell Models for Cardiotoxicity and Cardiovascular Disorders 132
7.4 Stem Cell Models for Toxicological Screenings of EDCs 133
References 135
8 Three-Dimensional Culture Systems and Humanized Liver Models Using Hepatic Stem Cells for Enhanced Toxicity Assessment 145 Ran-Ran Zhang, Yun-Wen Zhen
3 Stem Cells: A Potential Source for High Throughput Screening in Toxicology 26 Harish K Handral, Gopu Sriram, and Tong Cao
3.1 Introduction 26
3.2 Stem Cells 27
3.3 High Throughput Screening (HTS) 31
3.4 Need for a Stem Cell Approach in High Throughput Toxicity Studies 37
3.5 Role of Stem Cells in High Throughput Screening for Toxicity Prediction 38
3.6 Conclusion 40
Acknowledgement 41
Disclosure Statement 41
Author's Contribution 41
References 41
4 Human Pluripotent Stem Cells for Toxicological Screening 50 Lili Du and Dunjin Chen
4.1 Introduction 50
4.2 The Biological Characteristics of hPSCs 51
4.3 Screening of Embryotoxic Effects using hPSCs 52
4.4 The Potential of hPSC-Derived Neural Lineages in Neurotoxicology 55
4.5 The Potential of hPSC -Derived Cardiomyocytes in Cardiotoxicity 60
4.6 The Potential of hPSC-Derived Hepatocytes in Hepatotoxicity 62
4.7 Future Challenges and Perspectives for Embryotoxicity and Developmental Toxicity Studies using hPSCs 65
Acknowledgments 66
References 67
5 Effects of Culture Conditions on Maturation of Stem Cell-Derived Cardiomyocytes 71 Deborah K. Hansen, Amy L. Inselman, and Xi Yang
5.1 Introduction 71
5.2 Lengthening Culture Time 75
5.3 Substrate Stiffness 76
5.4 Structured Substrates 78
5.5 Conclusions 82
Disclaimer 82
References 83
6 Human Stem Cell-Derived Cardiomyocyte In Vitro Models for Cardiotoxicity Screening 85 Tracy Walker, Kate Harris, Evie Maifoshie, and Khuram Chaudhary
6.1 Introduction 85
6.2 Overview of hPSC-Derived Cardiomyocytes 88
6.3 Human PSC-CM Models for Cardiotoxicity Investigations 90
6.4 Conclusions and Future Direction 112
References 112
7 Disease-Specific Stem Cell Models for Toxicological Screenings and Drug Development 122 Matthias Jung, Juliane-Susanne Jung, Jovita Schiller, and Insa S. Schroeder
7.1 Evidence for Stem Cell-Based Drug Development and Toxicological Screenings in Psychiatric Diseases, Cardiovascular Diseases and Diabetes 122
7.2 Disease-Specific Stem Cell Models for Drug Development in Psychiatric Disorders 127
7.3 Stem Cell Models for Cardiotoxicity and Cardiovascular Disorders 132
7.4 Stem Cell Models for Toxicological Screenings of EDCs 133
References 135
8 Three-Dimensional Culture Systems and Humanized Liver Models Using Hepatic Stem Cells for Enhanced Toxicity Assessment 145 Ran-Ran Zhang, Yun-Wen Zhen
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