Uma Lakshmipathy, Jonathan D. Chesnut, Bhaskar Thyagarajan
Emerging Technology Platforms for Stem Cells
Uma Lakshmipathy, Jonathan D. Chesnut, Bhaskar Thyagarajan
Emerging Technology Platforms for Stem Cells
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This book focuses on practical applications for using adult and embryonic stem cells in the pharmaceutical development process. It emphasizes new technologies to help overcome the bottlenecks in developing stem cells as therapeutic agents. A key reference for professionals working in stem cell science, it presents the general principles and methodologies in stem cell research and covers topics such as derivitization and characterization of stem cells, stem cell culture and maintenance, stem cell engineering, applications of high throughput screening, and stem cell genetic modification with their use for drug delivery.…mehr
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This book focuses on practical applications for using adult and embryonic stem cells in the pharmaceutical development process. It emphasizes new technologies to help overcome the bottlenecks in developing stem cells as therapeutic agents. A key reference for professionals working in stem cell science, it presents the general principles and methodologies in stem cell research and covers topics such as derivitization and characterization of stem cells, stem cell culture and maintenance, stem cell engineering, applications of high throughput screening, and stem cell genetic modification with their use for drug delivery.
Produktdetails
- Produktdetails
- Verlag: Wiley & Sons
- Artikelnr. des Verlages: 14514693000
- 1. Auflage
- Seitenzahl: 512
- Erscheinungstermin: 1. April 2009
- Englisch
- Abmessung: 246mm x 162mm x 29mm
- Gewicht: 852g
- ISBN-13: 9780470146934
- ISBN-10: 0470146931
- Artikelnr.: 25933372
- Verlag: Wiley & Sons
- Artikelnr. des Verlages: 14514693000
- 1. Auflage
- Seitenzahl: 512
- Erscheinungstermin: 1. April 2009
- Englisch
- Abmessung: 246mm x 162mm x 29mm
- Gewicht: 852g
- ISBN-13: 9780470146934
- ISBN-10: 0470146931
- Artikelnr.: 25933372
Uma Lakshmipathy is a Principal Scientist at Life Technologies. She has a PhD in life sciences, with academic and industry experience in molecular biology and stem cells. Dr. Lakshmipathy holds two patents and has authored over thirty publications. Jonathan D. Chesnut is an R & D Director at Life Technologies, where he heads the stem cell engineering group. He holds five patents and has authored over twenty publications. Bhaskar Thyagarajan is a Program Manager at Life Technologies. He has a PhD in pharmacology, with expertise in the areas of molecular biology, DNA recombination, gene and cell therapy, and protein purification. He holds one patent and has authored over twenty publications.
Foreword Current state of stem cell field: Overview (Mahendra S. Rao).
Chapter 1: Derivation methods for human embryonic stem cells: Past, present
& future Necati Findikli. Mohan Vemuri. Chapter 2: Isolation of human ESCs
from various stages of the human embryo (Yuri Verlinsky, N. Strelchenko, V.
Kukharenko, A. Shkumatov, S. Rechitsky, O. Verlinsky, and A. Kuliev).
Chapter 3: Derivation of stem cells from epiblasts (Michal Amit). Chapter
4: Derivation of Embryonic Stem Cells from Parthenogenetic Eggs (Jose
Cibelli). Chapter 5: Reprogramming Developmental Potential (Costas A.
Lyssiotis Cradley D. Charette, and Luke L. Lairson). Chapter 6: Adult stem
cells and their role in endogenous tissue repair (N. Sachewsky and Cindi
Morshead). Chapter 7: Greater differentiation potential of adult stem cells
(Carlos Clavel and Catherine Verfaillie). Chapter 8: Cancer stem cells
(Scott Dylla, In-Kyung Park and Austin L. Gurney). Chapter 9: Large scale
production of adult stem cells for clinical use (Kristin Goltry, Brian
Hampson, Naia Venturi and Ronnda Bartel). Chapter 10: Genetic and
epigenetic features of stem cells (Jonathan Auerbach and Richard
Josephson). Chapter 11: Directed differentiation of embryonic stem cells
(Marjorie Pick). Chapter 12: Identification of signaling pathways involved
during differentiation Takumi Miura. Chapter 13 Media and extracellular
matrix requirements for large scale ESC growth (Allan J. Robins and Tom
Schultz). Chapter 14: Automated method for culturing ES cells (S. Terstegge
and Oliver Brustle). Chapter 15: Quantitative 2D Imaging of Human Embryonic
Stem Cells (Steven K.W. Oh, Allen K. Chen, Andre B.H. Choo and Ivan
Reading). Chapter 16: Nanobiotechonology for stem cell culture and
Maintenance (Minseok S. Kim, Wonhye Lee and Je-Kyun Park). Chapter 17:
Engineering Microenvironments to Control Stem Cell Functions (Anielle
An-Chi Tsou and Song Li). Chapter 18: Improved lentiviral gene delivery
tools for stem cells (Sanjay Vasu, Jian-Ping Yang and Wieslaw Kudlicki).
Chapter 19: Sleeping Beauty-mediated Transposition in Stem Cells (Andrew
Wilbur, Jakub Tolar, Bruce R Blazar, Catherine M Verfaillie, Uma
Lakshmipathy, Dan S Kaufman and Scott McIvor). Chapter 20: PhiC31 Integrase
for Modification of Stem Cells (W. Edward Jung and Michelle Calos). Chapter
21: Cell Engineering using Integrase and Recombinase systems (Takefumi
Sone, Fumiko Nishi, Kazuhide Yahata, Yukari Sasaki, Hiroe Kishine, Taichi
Andoh, Ken Inoue, Bhaskar Thyagarajan, Jonathan D. Chesnut and Fumio
Imamoto). Chapter 22: hESC derived cardiomyocytes for cell therapy and drug
discovery (William Sun and Robert Zweigerdt). Chapter 23: hESC in Drug
discovery (Catharina Ellerstrom, Petter Bjorquist, Peter Sartipy, Johan
Hyllner and Raimund Strehl). Chapter 24: Characterization and Culturing of
Adipose-Derived Precursor Cells (Dietmar Hutmacher, Joanna
Olkowska-Truchanowicz, David Leong, Johannes Reichert and Thiam Chye Lim).
Chapter 25: Bringing Mesenchymal stem cells to clinic (Robert Deans).
Chapter 1: Derivation methods for human embryonic stem cells: Past, present
& future Necati Findikli. Mohan Vemuri. Chapter 2: Isolation of human ESCs
from various stages of the human embryo (Yuri Verlinsky, N. Strelchenko, V.
Kukharenko, A. Shkumatov, S. Rechitsky, O. Verlinsky, and A. Kuliev).
Chapter 3: Derivation of stem cells from epiblasts (Michal Amit). Chapter
4: Derivation of Embryonic Stem Cells from Parthenogenetic Eggs (Jose
Cibelli). Chapter 5: Reprogramming Developmental Potential (Costas A.
Lyssiotis Cradley D. Charette, and Luke L. Lairson). Chapter 6: Adult stem
cells and their role in endogenous tissue repair (N. Sachewsky and Cindi
Morshead). Chapter 7: Greater differentiation potential of adult stem cells
(Carlos Clavel and Catherine Verfaillie). Chapter 8: Cancer stem cells
(Scott Dylla, In-Kyung Park and Austin L. Gurney). Chapter 9: Large scale
production of adult stem cells for clinical use (Kristin Goltry, Brian
Hampson, Naia Venturi and Ronnda Bartel). Chapter 10: Genetic and
epigenetic features of stem cells (Jonathan Auerbach and Richard
Josephson). Chapter 11: Directed differentiation of embryonic stem cells
(Marjorie Pick). Chapter 12: Identification of signaling pathways involved
during differentiation Takumi Miura. Chapter 13 Media and extracellular
matrix requirements for large scale ESC growth (Allan J. Robins and Tom
Schultz). Chapter 14: Automated method for culturing ES cells (S. Terstegge
and Oliver Brustle). Chapter 15: Quantitative 2D Imaging of Human Embryonic
Stem Cells (Steven K.W. Oh, Allen K. Chen, Andre B.H. Choo and Ivan
Reading). Chapter 16: Nanobiotechonology for stem cell culture and
Maintenance (Minseok S. Kim, Wonhye Lee and Je-Kyun Park). Chapter 17:
Engineering Microenvironments to Control Stem Cell Functions (Anielle
An-Chi Tsou and Song Li). Chapter 18: Improved lentiviral gene delivery
tools for stem cells (Sanjay Vasu, Jian-Ping Yang and Wieslaw Kudlicki).
Chapter 19: Sleeping Beauty-mediated Transposition in Stem Cells (Andrew
Wilbur, Jakub Tolar, Bruce R Blazar, Catherine M Verfaillie, Uma
Lakshmipathy, Dan S Kaufman and Scott McIvor). Chapter 20: PhiC31 Integrase
for Modification of Stem Cells (W. Edward Jung and Michelle Calos). Chapter
21: Cell Engineering using Integrase and Recombinase systems (Takefumi
Sone, Fumiko Nishi, Kazuhide Yahata, Yukari Sasaki, Hiroe Kishine, Taichi
Andoh, Ken Inoue, Bhaskar Thyagarajan, Jonathan D. Chesnut and Fumio
Imamoto). Chapter 22: hESC derived cardiomyocytes for cell therapy and drug
discovery (William Sun and Robert Zweigerdt). Chapter 23: hESC in Drug
discovery (Catharina Ellerstrom, Petter Bjorquist, Peter Sartipy, Johan
Hyllner and Raimund Strehl). Chapter 24: Characterization and Culturing of
Adipose-Derived Precursor Cells (Dietmar Hutmacher, Joanna
Olkowska-Truchanowicz, David Leong, Johannes Reichert and Thiam Chye Lim).
Chapter 25: Bringing Mesenchymal stem cells to clinic (Robert Deans).
Foreword Current state of stem cell field: Overview (Mahendra S. Rao).
Chapter 1: Derivation methods for human embryonic stem cells: Past, present
& future Necati Findikli. Mohan Vemuri. Chapter 2: Isolation of human ESCs
from various stages of the human embryo (Yuri Verlinsky, N. Strelchenko, V.
Kukharenko, A. Shkumatov, S. Rechitsky, O. Verlinsky, and A. Kuliev).
Chapter 3: Derivation of stem cells from epiblasts (Michal Amit). Chapter
4: Derivation of Embryonic Stem Cells from Parthenogenetic Eggs (Jose
Cibelli). Chapter 5: Reprogramming Developmental Potential (Costas A.
Lyssiotis Cradley D. Charette, and Luke L. Lairson). Chapter 6: Adult stem
cells and their role in endogenous tissue repair (N. Sachewsky and Cindi
Morshead). Chapter 7: Greater differentiation potential of adult stem cells
(Carlos Clavel and Catherine Verfaillie). Chapter 8: Cancer stem cells
(Scott Dylla, In-Kyung Park and Austin L. Gurney). Chapter 9: Large scale
production of adult stem cells for clinical use (Kristin Goltry, Brian
Hampson, Naia Venturi and Ronnda Bartel). Chapter 10: Genetic and
epigenetic features of stem cells (Jonathan Auerbach and Richard
Josephson). Chapter 11: Directed differentiation of embryonic stem cells
(Marjorie Pick). Chapter 12: Identification of signaling pathways involved
during differentiation Takumi Miura. Chapter 13 Media and extracellular
matrix requirements for large scale ESC growth (Allan J. Robins and Tom
Schultz). Chapter 14: Automated method for culturing ES cells (S. Terstegge
and Oliver Brustle). Chapter 15: Quantitative 2D Imaging of Human Embryonic
Stem Cells (Steven K.W. Oh, Allen K. Chen, Andre B.H. Choo and Ivan
Reading). Chapter 16: Nanobiotechonology for stem cell culture and
Maintenance (Minseok S. Kim, Wonhye Lee and Je-Kyun Park). Chapter 17:
Engineering Microenvironments to Control Stem Cell Functions (Anielle
An-Chi Tsou and Song Li). Chapter 18: Improved lentiviral gene delivery
tools for stem cells (Sanjay Vasu, Jian-Ping Yang and Wieslaw Kudlicki).
Chapter 19: Sleeping Beauty-mediated Transposition in Stem Cells (Andrew
Wilbur, Jakub Tolar, Bruce R Blazar, Catherine M Verfaillie, Uma
Lakshmipathy, Dan S Kaufman and Scott McIvor). Chapter 20: PhiC31 Integrase
for Modification of Stem Cells (W. Edward Jung and Michelle Calos). Chapter
21: Cell Engineering using Integrase and Recombinase systems (Takefumi
Sone, Fumiko Nishi, Kazuhide Yahata, Yukari Sasaki, Hiroe Kishine, Taichi
Andoh, Ken Inoue, Bhaskar Thyagarajan, Jonathan D. Chesnut and Fumio
Imamoto). Chapter 22: hESC derived cardiomyocytes for cell therapy and drug
discovery (William Sun and Robert Zweigerdt). Chapter 23: hESC in Drug
discovery (Catharina Ellerstrom, Petter Bjorquist, Peter Sartipy, Johan
Hyllner and Raimund Strehl). Chapter 24: Characterization and Culturing of
Adipose-Derived Precursor Cells (Dietmar Hutmacher, Joanna
Olkowska-Truchanowicz, David Leong, Johannes Reichert and Thiam Chye Lim).
Chapter 25: Bringing Mesenchymal stem cells to clinic (Robert Deans).
Chapter 1: Derivation methods for human embryonic stem cells: Past, present
& future Necati Findikli. Mohan Vemuri. Chapter 2: Isolation of human ESCs
from various stages of the human embryo (Yuri Verlinsky, N. Strelchenko, V.
Kukharenko, A. Shkumatov, S. Rechitsky, O. Verlinsky, and A. Kuliev).
Chapter 3: Derivation of stem cells from epiblasts (Michal Amit). Chapter
4: Derivation of Embryonic Stem Cells from Parthenogenetic Eggs (Jose
Cibelli). Chapter 5: Reprogramming Developmental Potential (Costas A.
Lyssiotis Cradley D. Charette, and Luke L. Lairson). Chapter 6: Adult stem
cells and their role in endogenous tissue repair (N. Sachewsky and Cindi
Morshead). Chapter 7: Greater differentiation potential of adult stem cells
(Carlos Clavel and Catherine Verfaillie). Chapter 8: Cancer stem cells
(Scott Dylla, In-Kyung Park and Austin L. Gurney). Chapter 9: Large scale
production of adult stem cells for clinical use (Kristin Goltry, Brian
Hampson, Naia Venturi and Ronnda Bartel). Chapter 10: Genetic and
epigenetic features of stem cells (Jonathan Auerbach and Richard
Josephson). Chapter 11: Directed differentiation of embryonic stem cells
(Marjorie Pick). Chapter 12: Identification of signaling pathways involved
during differentiation Takumi Miura. Chapter 13 Media and extracellular
matrix requirements for large scale ESC growth (Allan J. Robins and Tom
Schultz). Chapter 14: Automated method for culturing ES cells (S. Terstegge
and Oliver Brustle). Chapter 15: Quantitative 2D Imaging of Human Embryonic
Stem Cells (Steven K.W. Oh, Allen K. Chen, Andre B.H. Choo and Ivan
Reading). Chapter 16: Nanobiotechonology for stem cell culture and
Maintenance (Minseok S. Kim, Wonhye Lee and Je-Kyun Park). Chapter 17:
Engineering Microenvironments to Control Stem Cell Functions (Anielle
An-Chi Tsou and Song Li). Chapter 18: Improved lentiviral gene delivery
tools for stem cells (Sanjay Vasu, Jian-Ping Yang and Wieslaw Kudlicki).
Chapter 19: Sleeping Beauty-mediated Transposition in Stem Cells (Andrew
Wilbur, Jakub Tolar, Bruce R Blazar, Catherine M Verfaillie, Uma
Lakshmipathy, Dan S Kaufman and Scott McIvor). Chapter 20: PhiC31 Integrase
for Modification of Stem Cells (W. Edward Jung and Michelle Calos). Chapter
21: Cell Engineering using Integrase and Recombinase systems (Takefumi
Sone, Fumiko Nishi, Kazuhide Yahata, Yukari Sasaki, Hiroe Kishine, Taichi
Andoh, Ken Inoue, Bhaskar Thyagarajan, Jonathan D. Chesnut and Fumio
Imamoto). Chapter 22: hESC derived cardiomyocytes for cell therapy and drug
discovery (William Sun and Robert Zweigerdt). Chapter 23: hESC in Drug
discovery (Catharina Ellerstrom, Petter Bjorquist, Peter Sartipy, Johan
Hyllner and Raimund Strehl). Chapter 24: Characterization and Culturing of
Adipose-Derived Precursor Cells (Dietmar Hutmacher, Joanna
Olkowska-Truchanowicz, David Leong, Johannes Reichert and Thiam Chye Lim).
Chapter 25: Bringing Mesenchymal stem cells to clinic (Robert Deans).