Sepsis - Lehmann, Christian; Zhou, Juan; Caldwell, Charles C.
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Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Variability in pathogenesis and complex pathophysiology often delay diagnosis and create significant challenges for clinical studies in this group of critically ill patients. Mainly for those reasons, there is no therapy approved so far to overcome the underlying immune dysregulation. This book provides an overview about the state of the art of sepsis diagnostics and potential future therapies. Chapter 1 focuses on the immunologic staging of sepsis-the key for successful treatment of the…mehr

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Produktbeschreibung
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Variability in pathogenesis and complex pathophysiology often delay diagnosis and create significant challenges for clinical studies in this group of critically ill patients. Mainly for those reasons, there is no therapy approved so far to overcome the underlying immune dysregulation. This book provides an overview about the state of the art of sepsis diagnostics and potential future therapies. Chapter 1 focuses on the immunologic staging of sepsis-the key for successful treatment of the dysregulated hot response. Chapter 2 reveals similarities in the immune response in sepsis and cancer-opening new avenues for novel therapies. Chapter 3 introduces an important modulator of the immune response-the endogenous cannabinoid system and elucidates its role in organ dysfunction in sepsis. Facing the increasing bacterial resistance to classical antibiotics, Chapter 4 discusses two unique mechanisms to treat infection and inflammation in sepsis: iron chelation, and the sphingosine pathway. The authors, all experts in experimental and clinical sepsis research, seek to provide further understanding of the complexities of the immune response as the physiological basis for the development of new therapeutics in sepsis.
Autorenporträt
Dr. Christian Lehmann is Professor of Anesthesia, Pharmacology, Microbiology and Immunology, and Physiology and Biophysics at Dalhousie University, Halifax, NS, Canada. He is also Staff Anesthesiologist in the Department of Anesthesia, Nova Scotia Health Authority, Halifax. Dr. Lehmann has 25 years of experience in experimental and clinical inflammation research. He established experimental intravital imaging laboratories in Berlin and Greifswald, Germany. His focus of research is the microcirculation, i.e., capillary blood flow, cell-cell-interactions, and endothelial pathology. He participated in diverse German and international clinical multicenter trials, e.g., in sepsis. He joined Dalhousie University in 2007 and currently supervises research in three laboratories with modern equipment to study the microcirculation under various conditions experimentally and clinically. He is the author of more than 150 original publications, 13 book chapters and almost 200 published abstracts. He is a member of the Dalhousie Inflammation Group (DIG), the Microcirculation Diagnostics and Applied Studies (MiDAS) research group and the Cystic Fibrosis Translational Research (CFTR) group. In 2009, he founded the RESIST (Research in the Endocannabinoid System in Inflammation, Sepsis and Trauma) group with Dr. Melanie Kelly and others at Dalhousie University.