Role Of Fdg Pet-ct In Evaluation Of Gastrointestinal Stromal Tumors - Moustafa, Hosna;El-Hennawy, Gihan;El-kholy, Esraa
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Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal tumors of the gastrointestinal tract. A definition of a new entity among the gastrointestinal mesenchymal tumors called the gastrointestinal stromal tumors (GISTs) which express the kit (CD117) protein a growth factor trans-membrane receptor with tyrosine kinase activity. Surgery is the mainstay of therapy for non-metastatic GISTs. The c-kit tyrosine kinase inhibitor Imatinib (Glivec), was found to be useful in treating GISTs, leading to a 40-70% response rate in metastatic or inoperable cases.The current Response…mehr

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Produktbeschreibung
Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal tumors of the gastrointestinal tract. A definition of a new entity among the gastrointestinal mesenchymal tumors called the gastrointestinal stromal tumors (GISTs) which express the kit (CD117) protein a growth factor trans-membrane receptor with tyrosine kinase activity. Surgery is the mainstay of therapy for non-metastatic GISTs. The c-kit tyrosine kinase inhibitor Imatinib (Glivec), was found to be useful in treating GISTs, leading to a 40-70% response rate in metastatic or inoperable cases.The current Response Evaluation Criteria in solid tumors are based on uni-dimensional tumor size, and do not take into account changes in responding GISTs such as a decrease in tumor density and decrease in the number of intra-tumoral vessels with CT. PET/CT is highly sensitive in assessment early response to Imatinib mesylate. Also, it is useful in predicting long-term response to imatinib in patients with metastaticGIST; however, widespread use of PET is limited because of cost constraints.
Autorenporträt
Doutoramento em NM, Universidade do Cairo, Egipto 1979. Professor de NM, Universidade do Cairo 1990-até à data. Chefe do projeto AFRA NM no Egipto 2003-2020. Diretor da Sociedade Egípcia de Especialistas em NM 1998 - até à data. Diretor da revista egípcia de NM 2008-até agora. Número de apresentações internacionais 44. Número de apresentações nacionais 102.