Revival
Delivery Strategies for Antisense Oligonucleotide Therapeutics (1995)
Herausgeber: Akhtar, Saghir
Revival
Delivery Strategies for Antisense Oligonucleotide Therapeutics (1995)
Herausgeber: Akhtar, Saghir
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With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids. Important delivery issues, such as improving biological stability, improving cell-specific targeting and cellular uptake.
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With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids. Important delivery issues, such as improving biological stability, improving cell-specific targeting and cellular uptake.
Produktdetails
- Produktdetails
- Verlag: CRC Press
- Seitenzahl: 318
- Erscheinungstermin: 25. Januar 2019
- Englisch
- Abmessung: 234mm x 156mm x 17mm
- Gewicht: 445g
- ISBN-13: 9781138558571
- ISBN-10: 1138558575
- Artikelnr.: 56928967
- Verlag: CRC Press
- Seitenzahl: 318
- Erscheinungstermin: 25. Januar 2019
- Englisch
- Abmessung: 234mm x 156mm x 17mm
- Gewicht: 445g
- ISBN-13: 9781138558571
- ISBN-10: 1138558575
- Artikelnr.: 56928967
Saghir Akhtar
1. Preface 2. Overview of antisense oligonucleotide therapeutics and
delivery 3. Disrupting the flow of genetic information with antisense
oligodeoxynucleotides: research and therapeutic applications 4. Cellular
delivery of ribozymes 5. Improved structural design and cellular 6. Uptake
of gt-rich triplex-forming oligonucleotides 7. Pharmacokinetic and
distribution studies 8. Pharmacokinetics and delivery of oligonucleotides
to the brain 9. In vivo pharmacokinetics of oligonucleotides following
administration by different routes 10. Improving biological stability of
oligonucleotides 11. Nuclease-resistant nucleic acid therapeutics 12.
Self-stabilized oligonucleotides as novel antisense agents 13. Circular
oligonucleotides as potential modulators of gene expression 14. Peptide
nucleic acids as antisense therapeutic agents 15. Stabilized rna analogues
for antisense and ribozyme applications 16. Improving membrane transport
and targeted delivery of antisense oligonucleotides 17. Uptake and
localization of phosphodeister and chimeric 18. Oligodeoxynucleotides in
normal and leukaemic primary cells 19. Oligonucleotide transport across
membranes and into cells: effects of chemical modifications 20. Liposomes
as a delivery system for antisense and ribozyme compounds 21. Intracellular
delivery of oligonucleotides with cationic liposomes 22. The delivery of
oligonucleotides using ph-sensitive liposomes 23. Enhancing endsosomal exit
of nucleic acids using ph-sensitive viral fusion peptides 24. Targeted
delivery of anti-hepatitis b antisense oligonucleotides 25. Design,
synthesis, and cellular delivery of antibody antisense oligonucleotide
conjugates for cancer therapy
delivery 3. Disrupting the flow of genetic information with antisense
oligodeoxynucleotides: research and therapeutic applications 4. Cellular
delivery of ribozymes 5. Improved structural design and cellular 6. Uptake
of gt-rich triplex-forming oligonucleotides 7. Pharmacokinetic and
distribution studies 8. Pharmacokinetics and delivery of oligonucleotides
to the brain 9. In vivo pharmacokinetics of oligonucleotides following
administration by different routes 10. Improving biological stability of
oligonucleotides 11. Nuclease-resistant nucleic acid therapeutics 12.
Self-stabilized oligonucleotides as novel antisense agents 13. Circular
oligonucleotides as potential modulators of gene expression 14. Peptide
nucleic acids as antisense therapeutic agents 15. Stabilized rna analogues
for antisense and ribozyme applications 16. Improving membrane transport
and targeted delivery of antisense oligonucleotides 17. Uptake and
localization of phosphodeister and chimeric 18. Oligodeoxynucleotides in
normal and leukaemic primary cells 19. Oligonucleotide transport across
membranes and into cells: effects of chemical modifications 20. Liposomes
as a delivery system for antisense and ribozyme compounds 21. Intracellular
delivery of oligonucleotides with cationic liposomes 22. The delivery of
oligonucleotides using ph-sensitive liposomes 23. Enhancing endsosomal exit
of nucleic acids using ph-sensitive viral fusion peptides 24. Targeted
delivery of anti-hepatitis b antisense oligonucleotides 25. Design,
synthesis, and cellular delivery of antibody antisense oligonucleotide
conjugates for cancer therapy
1. Preface 2. Overview of antisense oligonucleotide therapeutics and
delivery 3. Disrupting the flow of genetic information with antisense
oligodeoxynucleotides: research and therapeutic applications 4. Cellular
delivery of ribozymes 5. Improved structural design and cellular 6. Uptake
of gt-rich triplex-forming oligonucleotides 7. Pharmacokinetic and
distribution studies 8. Pharmacokinetics and delivery of oligonucleotides
to the brain 9. In vivo pharmacokinetics of oligonucleotides following
administration by different routes 10. Improving biological stability of
oligonucleotides 11. Nuclease-resistant nucleic acid therapeutics 12.
Self-stabilized oligonucleotides as novel antisense agents 13. Circular
oligonucleotides as potential modulators of gene expression 14. Peptide
nucleic acids as antisense therapeutic agents 15. Stabilized rna analogues
for antisense and ribozyme applications 16. Improving membrane transport
and targeted delivery of antisense oligonucleotides 17. Uptake and
localization of phosphodeister and chimeric 18. Oligodeoxynucleotides in
normal and leukaemic primary cells 19. Oligonucleotide transport across
membranes and into cells: effects of chemical modifications 20. Liposomes
as a delivery system for antisense and ribozyme compounds 21. Intracellular
delivery of oligonucleotides with cationic liposomes 22. The delivery of
oligonucleotides using ph-sensitive liposomes 23. Enhancing endsosomal exit
of nucleic acids using ph-sensitive viral fusion peptides 24. Targeted
delivery of anti-hepatitis b antisense oligonucleotides 25. Design,
synthesis, and cellular delivery of antibody antisense oligonucleotide
conjugates for cancer therapy
delivery 3. Disrupting the flow of genetic information with antisense
oligodeoxynucleotides: research and therapeutic applications 4. Cellular
delivery of ribozymes 5. Improved structural design and cellular 6. Uptake
of gt-rich triplex-forming oligonucleotides 7. Pharmacokinetic and
distribution studies 8. Pharmacokinetics and delivery of oligonucleotides
to the brain 9. In vivo pharmacokinetics of oligonucleotides following
administration by different routes 10. Improving biological stability of
oligonucleotides 11. Nuclease-resistant nucleic acid therapeutics 12.
Self-stabilized oligonucleotides as novel antisense agents 13. Circular
oligonucleotides as potential modulators of gene expression 14. Peptide
nucleic acids as antisense therapeutic agents 15. Stabilized rna analogues
for antisense and ribozyme applications 16. Improving membrane transport
and targeted delivery of antisense oligonucleotides 17. Uptake and
localization of phosphodeister and chimeric 18. Oligodeoxynucleotides in
normal and leukaemic primary cells 19. Oligonucleotide transport across
membranes and into cells: effects of chemical modifications 20. Liposomes
as a delivery system for antisense and ribozyme compounds 21. Intracellular
delivery of oligonucleotides with cationic liposomes 22. The delivery of
oligonucleotides using ph-sensitive liposomes 23. Enhancing endsosomal exit
of nucleic acids using ph-sensitive viral fusion peptides 24. Targeted
delivery of anti-hepatitis b antisense oligonucleotides 25. Design,
synthesis, and cellular delivery of antibody antisense oligonucleotide
conjugates for cancer therapy