Retinoid Signaling Pathways

Herausgegeben:Pohl, Ehmke

• Gebundenes Buch

Produktbeschreibung

Retinoid Signaling Pathways, Volume 637, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Sections in this release include The chemistry and biochemistry of Vitamin A and its natural derivative, Biosynthesis of retinoic acids, Biodegration of retinoic acids mediated by retinoid binding proteins, Retinoic acid homeostasis, Cryo Electron Microscopy to study retinol update via the STRA6 receptor, Immuno-detection of retinoic acid synthesis enzymes in the brain, classical pathway of gene regulation by retinoids, Protein-protein interactions in the regulation of retinoid acid receptors activity, and much more.

Produktdetails

• Methods in Enzymology Volume 637
• Verlag: Academic Press / Elsevier Science & Technology
• Artikelnr. des Verlages: S0076-6879(20)X0009-7
• Englisch
• Abmessung: 31mm x 150mm x 229mm
• Gewicht: 1060g
• ISBN-13: 9780128201442
• Artikelnr.: 67578462

Inhaltsangabe

1. Vitamin A and its natural derivatives


Chris P.F. Redfern


2. Post-natal all-trans-retinoic acid biosynthesis


Joseph L. Napoli


3. Retinoid metabolism and functions mediated by retinoid binding-proteins


Joseph L. Napoli and Hong Sik Yoo


4. Generation and isolation of recombinant retinoid oxidoreductase complex


Mark K. Adams, Olga V. Belyaeva and Natalia Y. Kedishvili


5. Sample preparation for structural and functional analyses of the STRA6 receptor for retinol-binding protein


Brianna K. Costabile, Youn-Kyung Kim, Yunting Chen, Oliver B. Clarke, Loredana Quadro and Filippo Mancia


6. Use of fixatives for immunohistochemistry and their application for detection of retinoic acid synthesizing enzymes in the central nervous system


Azita Kouchmeshky and Peter McCaffery


7. Classical pathways of gene regulation by retinoids


Ehmke Pohl and Charles W.E. Tomlinson


8. Protein-protein interactions in the regulation of RAR-RXR heterodimers transcriptional activity


Albane le Maire, Pierre Germain and William Bourguet


9. Natural ligands of RXR receptors


Patricia García, Paula Lorenzo and Angel R. de Lera


10. DNA recognition by retinoic acid nuclear receptors


Carole Peluso-Iltis, Judit Osz and Natacha Rochel


11. Noncanonical retinoic acid signaling


Jennifer Nhieu, Yu-Lung Lin and Li-Na Wei


12. Retinoic acid and microRNA


Lijun Wang, Atharva Piyush Rohatgi and Yu-Jui Yvonne Wan


13. Analysis of vitamin A and retinoids in biological matrices


Lindsay C. Czuba, Guo Zhong, King Yabut and Nina Isoherranen


14. Effects of vitamin A and retinoic acid on mouse embryonic stem cells and their differentiating progeny


Mary Ann Asson-Batres and Christopher W. Norwood


15. Identifying vitamin A signaling by visualizing gene and protein activity, and by biochemical isolation of vitamin A metabolites


Stephen R. Shannon, Jianshi Yu, Amy E. Defnet, Danika Bongfeldt, Alexander R. Moise, Maureen A. Kane and Paul A. Trainor


16. Whole mount in situ hybridization and immunohistochemistry for studying retinoic acid signaling in developing amphioxus


Matteo Bozzo, Simona Candiani and Michael Schubert


17. Design of synthetic retinoids


David R. Chisholm and Andrew Whiting


18. Application of human organotypic skin raft cultures for analysis of retinoid metabolism, retinoic acid signaling, and screening of bioactive rexinoids


Alla V. Klyuyeva, Kelli R. Goggans, Natalia Y. Kedishvili and Olga V. Belyaeva


19. Tissue localization of retinoic acid receptor (RAR) active drugs


Azita Kouchmeshky, Timothy Goodman, Andy Whiting and Peter McCaffery


20. The development of methodologies for high-throughput retinoic acid binding assays in drug discovery and beyond


Charles W.E. Tomlinson and Andrew Whiting


21. Using the human CYP26A1 gene promoter as a suitable tool for the determination of RAR-mediated retinoid activity

Reza Zolfaghari, Floyd J. Mattie, Cheng-Hsin Wei, David R. Chisholm, Andrew Whiting and A. Catharine Ross