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The process of discovering a drug is critical to the society's progress in medical care and quality of life. Antimalarial drug resistance is one of the biggest challenges of malaria control today. Therefore, it is necessary to seek for new drugs that attack crucial targets in the malarial pathogen in order to combat and relieve this tremendous prevalence. Thus, in an effort to discover novel antimalarial agents; new compounds were designed in the present work by incorporating some pharmacophoric assemblies to the pyridine nucleus.