Mikhail Soloviev, Per Andrén, Chris Shaw

Peptidomics

Methods and Applications
Ed. by Mikhail Soloviev, Per Andren and Chris Shaw

• Gebundenes Buch

Produktbeschreibung

The first truly comprehensive book about peptidomics for protein and peptide analysis, Peptidomics: Methods and Applications offers a detailed description of the hows and whys of technique, and how it has evolved. It details methods and describes typical applications, including the use of peptidomics for drug discovery and toxicity analysis. The book provides information that is both sufficiently detailed to be a step-by-step guide for beginning researchers, while also being a reference for experienced professionals. The book explains the current state of the field, new developments now emerging, and examples of applications for fields from pharmaceutical science, to toxicity biomarkers, to neuroscience.

---

The definitive guide to peptidomics- a hands-on lab reference

The first truly comprehensive book about peptidomics for protein and peptide analysis, this reference provides a detailed description of the hows and whys of peptidomics and how the techniques have evolved. With chapters contributed by leading experts, it covers naturally occurring peptides, peptidomics methods and new developments, and the peptidomics approach to biomarker discovery. Explaining both the principles and the applications, Peptidomics: Methods and Applications:
_

Features examples of applications in diverse fields, including pharmaceutical science, toxicity biomarkers, and neuroscience
_

Details the successful peptidomic analyses of biological material ranging from plants to mammals
_

Describes a cross section of analytical techniques, including traditional methodologies, emerging trends, and new techniques for high throughput approaches

An enlightening reference for experienced professionals, this book is sufficiently detailed to serve as a step-by-step guide for beginning researchers and an excellent resource for students taking biotechnology and proteomics courses. It is an invaluable reference for protein chemists and biochemists, professionals and researchers in drug and biopharmaceutical development, analytical and bioanalytical chemists, toxicologists, and others.

Produktdetails

• Verlag: Wiley & Sons
• Artikelnr. des Verlages: 14667781000
• 1. Auflage
• Seitenzahl: 424
• Erscheinungstermin: 14. Dezember 2007
• Englisch
• Abmessung: 236mm x 160mm x 28mm
• Gewicht: 740g
• ISBN-13: 9780471677819
• ISBN-10: 0471677817
• Artikelnr.: 23170961

Autorenporträt

Mikhail Soloviev is a Senior Lecturer in Biological Chemistry at theRoyal Holloway University of London and serves as the Editor-in-Chiefof the Journal of Nanobiotechnology. CHRIS SHAW is a Professor in DrugDiscovery in the School of Pharmacy at Queen's University in Belfast.PER ANDRéN is an Adjunct Professor in the Department of Pharmaceutical Biosciences at Uppsala University in Sweden.

Inhaltsangabe

SECTION 1: STUDIES OF NATURALLY OCCURRING PEPTIDES. Chapter 1: Analysis of
the peptidomes of amphibian skin granular gland secretions - an integrated
functional genomic strategy (Chris Shaw, and Tianbao Chen). Chapter 2: A
short history of insect (neuro)peptidomics - A personal story of the birth
and youth of an excellent model for studying peptidome biology (Peter
D.E.M. Verhaert, Martijn W.H. Pinkse, Maria C. Prieto-Conaway, and Markus
Kellmann). Chapter 3: Peptidomics of short linear cytolytic peptides from
spider venom (Sergey A. Kozlov, Alexander A. Vassilevski, and Eugene V.
Grishin). Chapter 4: Molecular cloning approaches to peptidomics: the
identification of novel cDNAs encoding neurotoxin-like peptide pools
(Zhensheng Pan, Richard Barry, and Mikhail Soloviev). Chapter 5: Wheat
antimicrobial peptides (Tatyana I. Odintsova, and Tsezi A. Egorov). Chapter
6: Immunopeptidomics: Applications to dissect immune responses through
proteomic-based approaches (Ernesto Oviedo-Orta, and Alexandra
Bermudez-Fajardo). Chapter 7: Strategies for reliable and improved
identification of peptides (Karl Skuld, Maria Folth, Marcus Svensson, Anna
Nilsson, Per Svenningsson, and Per E. Andrun). SECTION 2: PEPTIDOMICS
METHODS AND NEW DEVELOPMENTS. Chapter 8: Peptidomics approach to proteomics
(Petra Zarbig, and Harald Mischak). Chapter 9: The importance of sample
handling in neuropeptidomics (Karl Skuld, Marcus Svensson, Anna Nilsson,
Maria Folth, Per Svenningsson, and Per E. Andrun). Chapter 10: Affinity
peptidomics and protein microarrays: application to forensics and
biometrics (Julian Bailes, and Mikhail Soloviev). Chapter 11: Selective
depletion and enrichment methods for the analysis of protein and peptide
pools (Paul Finch, and Mikhail Soloviev). Chapter 12: Detection of target
peptides in foods and feeds by mass spectrometry (Mireia Fernandez Ocaca).
Chapter 13: Quantification of Polypeptides by Mass Spectrometry (Pedro R.
Cutillas). SECTION 3: PEPTIDOMICS APPROACH TO BIOMARKER DISCOVERY. Chapter
14: Biomarker discovery (Petra Zarbig, and Harald Mischak). Chapter 15: Can
peptidomics provide a useful approach for the identification of biomarkers
of toxicological exposure or effect (Helen Griffiths)? Chapter 16:
Peptidomics in Neuroendocrine research: a Caenorhabditis elegans and Mus
musculus study (Kurt Boonen, Steven J. Husson, Geert Baggerman, Anja
Cerstiaens, Walter Luyten, and Liliane Schoofs). CONCLUSION. Chapter 17:
Peptidomics and Biology: two scientific disciplines driving each other
(Chris Shaw, and Peter D.E.M. Verhaert).