This book gives researchers and their associates a comprehensivereview of the biochemistry, absorption, metabolism, biologicalactivities, disease prevention, and health promotion of glutathioneand sulfur amino acids. Discussion deals with the complexrelationship between GSH and sulfur amino acids and theirphysiological role, as well as they and their metabolites'possible role in chronic-degenerative diseases. Special attentionis paid to the molecular mechanisms for the modulation oftranscription factors and enzyme activities. Finally, the bookcovers the nutritional and therapeutic significance…mehr
This book gives researchers and their associates a comprehensivereview of the biochemistry, absorption, metabolism, biologicalactivities, disease prevention, and health promotion of glutathioneand sulfur amino acids. Discussion deals with the complexrelationship between GSH and sulfur amino acids and theirphysiological role, as well as they and their metabolites'possible role in chronic-degenerative diseases. Special attentionis paid to the molecular mechanisms for the modulation oftranscription factors and enzyme activities. Finally, the bookcovers the nutritional and therapeutic significance of dietarysulfur amino acids, as shown in human and animal models.
Roberta Masella works as Head of the Human Nutrition Unit, Department of Veterinary Public Health and Food Safety, at Istituto Superiore di Sanità (ISS). She was previously head of the Gastroenterology Unit in the Laboratory of Metabolism and Pathological Biochemistry at ISS. She is the author of nearly 100 peer-reviewed publications, as well as seventy presentations at international congresses. Giuseppe (Joe) Mazza is the Principal Food and Bioscience Research Scientist at Agriculture and Agri-Food Canada, Summerland, British Columbia, and an adjunct professor in food science and nutrition at the Universities of Manitoba and British Columbia. A prolific author and editor of over 200 journal articles and twelve books, he is on the editorial boards of World of Food Science, Plant Foods for Human Nutrition, Italian Journal of Food Science, and Journal of Functional Foods.
Inhaltsangabe
PREFACE. CONTRIBUTORS. I INTRODUCTION. 1 GLUTATHIONE AND THE SULFUR-CONTAINING AMINO ACIDS: AN OVERVIEW (John T. Brosnan and Margaret E. Brosnan). Acknowledgments. References. II CHEMISTRY AND METABOLISM OF GSH AND SULFUR AMINO ACIDS. 2 SULFUR AMINO ACIDS CONTENTS OF DIETARY PROTEINS: DAILY INTAKE AND REQUIREMENTS (Cécile Bos, Jean-François Huneau, and Claire Gaudichon). References. 3 CELLULAR COMPARTMENTALIZATION OF GLUTATHIONE (Federico V. Pallardó, Jelena Markovic, and José Vinã). References. 4 INTESTINAL METABOLISM OF SULFUR AMINO ACIDS (Nancy Benight, Douglas G. Burrin, and Barbara Stoll). References. 5 HEPATIC SULFUR AMINO ACID METABOLISM (Kevin L. Schalinske). References. III ANTIOXIDANT AND DETOXIFICATION ACTIVITIES. 6 GLUTATHIONE AND SULFUR CONTAINING AMINO ACIDS: ANTIOXIDANTAND CONJUGATION ACTIVITIES (Nils-Erik Huseby, Elisabeth Sundkvist, and Gunbjørg Svineng). References. 7 GLUTAREDOXIN AND THIOREDOXIN ENZYME SYSTEMS: CATALYTIC MECHANISMS AND PHYSIOLOGICAL FUNCTIONS (Elizabeth A. Sabens and John J. Mieyal). References. 8 METHIONINE SULFOXIDE REDUCTASES: A PROTECTIVE SYSTEM AGAINST OXIDATIVE DAMAGE (Herbert Weissbach and Nathan Brot). Acknowledgment. References. IV BIOACTIVITY OF GSH AND SULFUR AMINO ACIDS AS REGULATORS OF CELLULAR PROCESSES. 9 REGULATION OF PROTEIN FUNCTION BY GLUTATHIONYLATION (Pietro Ghezzi and Paolo Di Simplicio). References. 10 GSH, SULFUR AMINO ACIDS, AND APOPTOSIS (Giuseppe Filomeni, Katia Aquilano, and Maria Rosa Ciriolo). Acknowledgments. References. 11 METHIONINE OXIDATION: IMPLICATION IN PROTEIN REGULATION, AGING, AND AGING-ASSOCIATED DISEASES (Jackob Moskovitz and Derek B. Oien). References. 12 SULFUR AMINO ACIDS, GLUTATHIONE, AND IMMUNE FUNCTION (Robert Grimble). References. V GSH AND SULFUR AMINO ACIDS IN PATHOLOGICAL PROCESSES. 13 SULFUR AMINO ACID DEFICIENCY AND TOXICITY: RESEARCH WITH ANIMAL MODELS (David H. Baker and Ryan N. Dilger). References. 14 HUMAN PATHOLOGIES AND ABERRANT SULFUR METABOLISM (Danyelle M. Townsend, Haim Tapiero, and Kenneth D. Tew). References. 15 INBORN ERRORS OF GSH METABOLISM (llinor Ristoff). Acknowledgments. References. 16 HOMOCYSTEINE METABOLISM AND PATHOLOGICAL IMPLICATIONS: THE HOMOCYSTEINE THIOLACTONE HYPOTHESIS OF VASCULAR DISEASE (Hieronim Jakubowski). References. 17 HOMOCYSTEINE AND CARDIOVASCULAR DISEASE (Jayanta R. Das and Sanjay Kaul). References. 18 HOMOCYSTEINE AND NEUROLOGICAL DISORDERS (Rodica E. Petrea and Sudha Seshadri). References. 19 GLUTATHIONE, SULFUR AMINO ACIDS, AND CANCER (José M. Estrela, Julian Carretero, and Angel Ortega). References. VI GSH AND SULFUR AMINO ACIDS AS DRUGS AND NUTRACEUTICALS. 20 GSH, GSH DERIVATIVES, AND ANTIVIRAL ACTIVITY (Anna Teresa Palamara, Lucia Nencioni, Rossella Sgarbanti, and Enrico Garaci). References. 21 N-ACETYL CYSTEINE AND CYTOPROTECTIVE EFFECTS AGAINST BRONCHOPULMONARY DAMAGE: FROM IN VITRO STUDIES TO CLINICAL APPLICATION (Richard Dekhuijzen). References. 22 TAURINE AS DRUG AND FUNCTIONAL FOOD COMPONENT (Ramesh C. Gupta, Massimo D'Archivio, and Roberta Masella). References. SUBJECT INDEX.
PREFACE. CONTRIBUTORS. I INTRODUCTION. 1 GLUTATHIONE AND THE SULFUR-CONTAINING AMINO ACIDS: AN OVERVIEW (John T. Brosnan and Margaret E. Brosnan). Acknowledgments. References. II CHEMISTRY AND METABOLISM OF GSH AND SULFUR AMINO ACIDS. 2 SULFUR AMINO ACIDS CONTENTS OF DIETARY PROTEINS: DAILY INTAKE AND REQUIREMENTS (Cécile Bos, Jean-François Huneau, and Claire Gaudichon). References. 3 CELLULAR COMPARTMENTALIZATION OF GLUTATHIONE (Federico V. Pallardó, Jelena Markovic, and José Vinã). References. 4 INTESTINAL METABOLISM OF SULFUR AMINO ACIDS (Nancy Benight, Douglas G. Burrin, and Barbara Stoll). References. 5 HEPATIC SULFUR AMINO ACID METABOLISM (Kevin L. Schalinske). References. III ANTIOXIDANT AND DETOXIFICATION ACTIVITIES. 6 GLUTATHIONE AND SULFUR CONTAINING AMINO ACIDS: ANTIOXIDANTAND CONJUGATION ACTIVITIES (Nils-Erik Huseby, Elisabeth Sundkvist, and Gunbjørg Svineng). References. 7 GLUTAREDOXIN AND THIOREDOXIN ENZYME SYSTEMS: CATALYTIC MECHANISMS AND PHYSIOLOGICAL FUNCTIONS (Elizabeth A. Sabens and John J. Mieyal). References. 8 METHIONINE SULFOXIDE REDUCTASES: A PROTECTIVE SYSTEM AGAINST OXIDATIVE DAMAGE (Herbert Weissbach and Nathan Brot). Acknowledgment. References. IV BIOACTIVITY OF GSH AND SULFUR AMINO ACIDS AS REGULATORS OF CELLULAR PROCESSES. 9 REGULATION OF PROTEIN FUNCTION BY GLUTATHIONYLATION (Pietro Ghezzi and Paolo Di Simplicio). References. 10 GSH, SULFUR AMINO ACIDS, AND APOPTOSIS (Giuseppe Filomeni, Katia Aquilano, and Maria Rosa Ciriolo). Acknowledgments. References. 11 METHIONINE OXIDATION: IMPLICATION IN PROTEIN REGULATION, AGING, AND AGING-ASSOCIATED DISEASES (Jackob Moskovitz and Derek B. Oien). References. 12 SULFUR AMINO ACIDS, GLUTATHIONE, AND IMMUNE FUNCTION (Robert Grimble). References. V GSH AND SULFUR AMINO ACIDS IN PATHOLOGICAL PROCESSES. 13 SULFUR AMINO ACID DEFICIENCY AND TOXICITY: RESEARCH WITH ANIMAL MODELS (David H. Baker and Ryan N. Dilger). References. 14 HUMAN PATHOLOGIES AND ABERRANT SULFUR METABOLISM (Danyelle M. Townsend, Haim Tapiero, and Kenneth D. Tew). References. 15 INBORN ERRORS OF GSH METABOLISM (llinor Ristoff). Acknowledgments. References. 16 HOMOCYSTEINE METABOLISM AND PATHOLOGICAL IMPLICATIONS: THE HOMOCYSTEINE THIOLACTONE HYPOTHESIS OF VASCULAR DISEASE (Hieronim Jakubowski). References. 17 HOMOCYSTEINE AND CARDIOVASCULAR DISEASE (Jayanta R. Das and Sanjay Kaul). References. 18 HOMOCYSTEINE AND NEUROLOGICAL DISORDERS (Rodica E. Petrea and Sudha Seshadri). References. 19 GLUTATHIONE, SULFUR AMINO ACIDS, AND CANCER (José M. Estrela, Julian Carretero, and Angel Ortega). References. VI GSH AND SULFUR AMINO ACIDS AS DRUGS AND NUTRACEUTICALS. 20 GSH, GSH DERIVATIVES, AND ANTIVIRAL ACTIVITY (Anna Teresa Palamara, Lucia Nencioni, Rossella Sgarbanti, and Enrico Garaci). References. 21 N-ACETYL CYSTEINE AND CYTOPROTECTIVE EFFECTS AGAINST BRONCHOPULMONARY DAMAGE: FROM IN VITRO STUDIES TO CLINICAL APPLICATION (Richard Dekhuijzen). References. 22 TAURINE AS DRUG AND FUNCTIONAL FOOD COMPONENT (Ramesh C. Gupta, Massimo D'Archivio, and Roberta Masella). References. SUBJECT INDEX.
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