This book provides a complete view of what it takes to develop peptide-based medicine from a chemistry perspective and insights into the future of peptide drugs.
This book provides a complete view of what it takes to develop peptide-based medicine from a chemistry perspective and insights into the future of peptide drugs.
Ved Srivastava is Vice President of Chemistry and co-founder at Phoundry Pharmaceuticals, and prior to that he was head of Peptide Chemistry at GlaxoSmithKline and Vice President of research and production at New England Peptide. He spent several years with Amylin Pharmaceuticals where he focused on discovery and development of novel peptide hormones for diabetes, obesity and neuropsychiatric therapies. He has significantly contributed in the development of ByettaTM, SymlinTM and BydeureonTM for the treatment of diabetes. He also directed the research chemistry team of Psylin Neurosciences, Inc., a biotech company formed as a joint venture between Amylin Pharmaceuticals, Inc. and PshychoGenics, Inc. Ved has over 25 years of experience with expertise in drug discovery in the area metabolic diseases and inflammation with major emphasis in peptide medicinal chemistry and peptide delivery. He earned a Ph.D.in organic chemistry from the University of Lucknow, India and had subsequent postdoctoral appointments at the University of Georgia and the University of Colorado Medical School. Ved is energetically involved in the governance of the American Peptide Society.
Inhaltsangabe
Renaissance in Peptide Drug Discovery: The Third Wave Identification and Validation of Peptide Therapeutic Targets and Indications Peptide Biomarkers and Assay Development Peptide Libraries Technologies: Mixture Based Libraries Generation and Screening Macrocyclic peptides for intracellular drug targets Structural Design for Bioactive Peptides Peptide Lead Optimization - Strategies and Tactics ADME Properties of Peptide Therapeutics in Drug Discovery and Development Optimizing Peptides for Metabolic Diseases Peptide Therapeutics-Oncology Development of Peptide-based Diagnostic and Therapeutic Agents in Oncology Designing an Effective Peptide Vaccine Peptide Therapeutics: Neuropeptides From Spider Toxins to Therapeutics---Developing Selective Nav1.7 Peptide Inhibitors for Pain Structure and Function of Stress Responsive Peptides in Insects Technologies for Oral Delivery of Peptides Phylomer Libraries: A Rich Source of Peptide Hits in Phenotypic and Target Directed Screens Solid-Phase Peptide Synthesis, the State of the Art: Challenges and Opportunities
Renaissance in Peptide Drug Discovery: The Third Wave Identification and Validation of Peptide Therapeutic Targets and Indications Peptide Biomarkers and Assay Development Peptide Libraries Technologies: Mixture Based Libraries Generation and Screening Macrocyclic peptides for intracellular drug targets Structural Design for Bioactive Peptides Peptide Lead Optimization - Strategies and Tactics ADME Properties of Peptide Therapeutics in Drug Discovery and Development Optimizing Peptides for Metabolic Diseases Peptide Therapeutics-Oncology Development of Peptide-based Diagnostic and Therapeutic Agents in Oncology Designing an Effective Peptide Vaccine Peptide Therapeutics: Neuropeptides From Spider Toxins to Therapeutics---Developing Selective Nav1.7 Peptide Inhibitors for Pain Structure and Function of Stress Responsive Peptides in Insects Technologies for Oral Delivery of Peptides Phylomer Libraries: A Rich Source of Peptide Hits in Phenotypic and Target Directed Screens Solid-Phase Peptide Synthesis, the State of the Art: Challenges and Opportunities
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