Nanoparticulate Drug Delivery Systems
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This book provides an overview of nanoparticulate drug delivery systems, their potential applications and limitations. The chapters focus on new approaches, manufacturing methodologies, and applications of nanotechnology in drug delivery. Chapter 1 provides an overview of targeted nanomedicine and ddresses strategies developed to overcome limitations of existing systems. It covers a variety of specific topics like dendrimer-based drug delivery, the new liposome system, polymeric nanoparticle systems, and nanocrystals. Part 2 covers preclinical and clinical applications of nanoparticulate…mehr

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Produktbeschreibung
This book provides an overview of nanoparticulate drug delivery systems, their potential applications and limitations. The chapters focus on new approaches, manufacturing methodologies, and applications of nanotechnology in drug delivery. Chapter 1 provides an overview of targeted nanomedicine and ddresses strategies developed to overcome limitations of existing systems. It covers a variety of specific topics like dendrimer-based drug delivery, the new liposome system, polymeric nanoparticle systems, and nanocrystals. Part 2 covers preclinical and clinical applications of nanoparticulate systems that have identified their new potentials or biological barriers interfering with the delivery. Each chapter reviews state-of-the-art topics, includes extensive references, and assesses challenges in the field. Overall, this book delivers up-to-date information on nanoparticulate drug delivery systems for students, researchers and professionals in the pharmaceutical, biomedical engineering, and related health sciences industries.
Frank discussions of opportunities and challenges point the way to new, more effective drug delivery systems

Interest in nanomedicine has grown tremendously, fueled by the expectation that continued research will lead to the safe, efficient, and cost-effective delivery of drugs or imaging agents to human tissues and organs. The field, however, has faced several challenges attempting to translate novel ideas into clinical benefits. With contributions from an international team of leading nanomedicine researchers, this book provides a practical assessment of the possibilities and the challenges of modern nanomedicine that will enable the development of clinically effective nanoparticulate drug delivery products and systems.

Nanoparticulate Drug Delivery Systems focuses on the rationales and preclinical evaluation of new nanoparticulate drug carriers that have yet to be thoroughly reviewed in the literature. The first chapter sets the stage with a general overview of targeted nanomedicine. The book then explores new and promising nanoparticulate drug delivery systems, including:
Lipid nanoparticles for the delivery of nucleic acids
Multifunctional dendritic nanocarriers
Polymer drug nanoconjugates

Next, the book presents new opportunities and challenges for nanoparticulate drug delivery systems, including:
Clearance of nanoparticles during circulation
Drug delivery strategies for combatting multiple drug resistance
Toxicological assessment of nanomedicine

Chapters offer state-of-the-technology reviews with extensive references to facilitate further investigation. Moreover, each chapter concludes with an expert assessment of remaining challenges, pointing the way to solutions and new avenues of research.

With its frank discussions of opportunities and challenges, Nanoparticulate Drug Delivery Systems sets a solid foundation for new research leading to the discovery and development of better nanomedicines.
Autorenporträt
YOON YEO, PhD, is Assistant Professor of Industrial and Physical Pharmacy at the College of Pharmacy at Purdue University. She also holds a joint appointment as Assistant Professor at Purdue's Weldon School of Biomedical Engineering. Her research focuses on nanoparticle surface engineering for drug delivery to solid tumors, inhalable drug/gene delivery for cystic fibrosis therapy, and functional biomaterials based on carbohydrates. Dr. Yeo is the recipient of the NSF CAREER Award as well as New Investigator awards from both the American Association of Pharmaceutical Scientists and the American Association of Colleges of Pharmacy.