Ashim Mitra, Chi H. Lee, Kun Cheng

Advanced Drug Delivery

• Gebundenes Buch

Produktbeschreibung

Offering a holistic view of the development of drug delivery systems, Advanced Drug Delivery presents the essential aspects necessary to understand and apply for effective drug delivery fundamentals, including practical issues, integration of pharmaceutics, and molecular biology. A suitable text for graduate and advanced undergraduate students, the book is logically divided into four sections: fundamentals, delivery approaches, disease applications, and future directions. Discussing design, in vitro studies, clinical evaluation, and regulatory approval, each chapter includes objectives and assessment questions.

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Provides both fundamentals and new and emerging applications

Advanced Drug Delivery brings readers fully up to date with the state of the science, presenting the basics, formulation strategies, and therapeutic applications of advanced drug delivery. The book demonstrates how core concepts of pharmaceutical sciences, chemistry, and molecular biology can be combined and applied in order to spark novel ideas to design and develop advanced drug delivery systems for the treatment of a broad range of human diseases.

Advanced Drug Delivery features contributions from an international team of pharmaceutical scientists. Chapters reflect a thorough review and analysis of the literature as well as the authors' firsthand experience developing drug delivery systems. The book is divided into four parts:
Part I, Introduction and Basics of Advanced Drug Delivery, explores physiological barriers, stability, transporters, and biomaterials in drug delivery
Part II, Strategies for Advanced Drug Delivery, offers tested and proven strategies for advanced delivery of both small molecules and macromolecules
Part III, Translational Research of Advanced Drug Delivery, focuses on regulatory considerations and translational applications of advanced drug delivery systems for the treatment of cardiovascular diseases, cancer, sexually transmitted diseases, ophthalmic diseases, and brain diseases
Part IV, Future Applications of Advanced Drug Delivery in Emerging Research Areas, examines stem cell research, cell-based therapeutics, tissue engineering, and molecular imaging

Each chapter provides objectives and assessment questions to help readers grasp key concepts and assess their knowledge as they progress through the book.

Advanced Drug Delivery is recommended for graduates and upper-level undergraduates in the pharmaceutical sciences who need a solid foundation in the basics. It is also recommended for pharmaceutical professionals who want to take advantage of new and emerging applications in advanced drug delivery systems.

Produktdetails

• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 530
• Erscheinungstermin: 4. November 2013
• Englisch
• Abmessung: 284mm x 222mm x 38mm
• Gewicht: 1458g
• ISBN-13: 9781118022665
• ISBN-10: 1118022661
• Artikelnr.: 38025172

Autorenporträt

ASHIM K. MITRA, PhD, is Chairman of Pharmaceutical Sciences at the University of Missouri-Kansas City. Dr. Mitra is also a University of Missouri Curators' Professor and has more than thirty years of experience in the field of ocular drug delivery and disposition. He has been the recipient of research awards from the NIH, AAPS, AACP, ARVO, and other pharmaceutical organizations. CHI H. LEE, PhD, is Professor of Pharmaceutical Sciences at the University of Missouri-Kansas City, where he teaches undergraduate and graduate pharmacy courses. His research focuses on elucidation of pathological mechanisms and formulation development of microbicidal and cardiovascular devices. KUN CHENG, PhD, is Associate Professor of Pharmaceutical Sciences at the University of Missouri-Kansas City. His research seeks to develop novel drug delivery systems for siRNA and small molecule drugs. Dr. Cheng is the recipient of the 2011 American Association of Pharmaceutical Scientists (AAPS) New Investigator Grant Award in Pharmaceutics and Pharmaceutical Technologies.

Inhaltsangabe

PREFACE xi ABOUT THE AUTHORS xiii CONTRIBUTORS xv PART I INTRODUCTION AND BASICS OF ADVANCED DRUG DELIVERY 1 1 Physiological Barriers in Advanced Drug Delivery: Gastrointestinal Barrier 3 D. Alexander Oh and Chi H. Lee 2 Solubility and Stability Aspects in Advanced Drug Delivery 21 Hoo-Kyun Choi
Robhash K. Subedi
and Chi H. Lee 3 The Role of Transporters and the Efflux System in Drug Delivery 47 Varun Khurana
Dhananjay Pal
Mukul Minocha
and Ashim K. Mitra 4 Biomaterial in Advanced Drug Delivery 75 Megha Barot
Mitesh Patel
Xiaoyan Yang
Wuchen Wang
and Chi H. Lee PART II STRATEGIES FOR ADVANCED DRUG DELIVERY 103 5 Strategies of Drug Targeting 105 Ravi S. Shukla
Zhijin Chen
and Kun Cheng 6 Prodrug and Bioconjugation 123 Ramya Krishna Vadlapatla
Sujay Shah
Aswani Dutt Vadlapudi
and Ashim K. Mitra 7 Nanoscale Drug Delivery Systems 141 Mitan R. Gokulgandhi
Ashaben Patel
Kishore Cholkar
Megha Barot
and Ashim K. Mitra 8 Stimuli-Responsive Target Strategies 157 Chi H. Lee 9 Implants 183 Aswani Dutt Vadlapudi
Ashaben Patel
Ramya Krishna Vadlapatla
Durga Paturi
and Ashim K. Mitra 10 Aptamers in Advanced Drug Delivery 201 Weiwei Gao
Omid C. Farokhzad
and Nazila Kamaly 11 Nanofiber 219 Megha Barot
Mitan R. Gokulgandhi
Animikh Ray
and Ashim K. Mitra 12 Biomimetic Self-Assembling Nanoparticles 231 Maxim G. Ryadnov 13 Protein and Peptide Drug Delivery 241 Mitesh Patel
Megha Barot
Jwala Renukuntla
and Ashim K. Mitra 14 Delivery of Nucleic Acids 257 Shaoying Wang
Bin Qin
and Kun Cheng 15 Delivery of Vaccines 275 Hari R. Desu
Rubi Mahato
and Laura A. Thoma PART III TRANSLATIONAL RESEARCH OF ADVANCED DRUG DELIVERY 297 16 Regulatory Considerations and Clinical Issues in Advanced Drug Delivery 299 Mei-Ling Chen 17 Advanced Drug Delivery in Cancer Therapy 323 Wanyi Tai and Kun Cheng 18 Advanced Delivery in Cardiovascular Diseases 341 Gayathri Acharya
Wuchen Wang
Divya Teja Vavilala
Mridul Mukherji
and Chi H. Lee 19 Recent Advances in Ocular Drug Delivery 365 Varun Khurana
Deep Kwatra
Vibhuti Agrahari
and Ashim K. Mitra 20 Advanced Drug Delivery Against STD 381 Chi H. Lee 21 Advanced Drug Delivery to the Brain 405 Nanda K. Mandava
Mitesh Patel
and Ashim K. Mitra PART IV FUTURE APPLICATIONS OF ADVANCED DRUG DELIVERY IN EMERGING RESEARCH AREAS 423 22 Cell-Based Therapeutics 425 Zhaoyang Ye
Yan Zhou
Haibo Cai
and Wen-Song Tan 23 Biomedical Applications and Tissue Engineering of Collagen 445 Chi H. Lee and Yugyung Lee 24 Molecular Imaging of Drug Delivery 469 Zheng-Rong Lu ANSWERS 489 INDEX 511

Rezensionen

"This book is a welcome addition to the range of study materials available at this level and can be unreservedly recommended to both aspiring and existing pharmaceutical professionals." (ChemMedChem, 1 January 2015)

"A suitable text for graduate and advanced undergraduate students, the book is logically divided into four sections: fundamentals, delivery approaches, disease applications, and future directions. Discussing design, in vitro studies, clinical evaluation, and regulatory approval, each chapter includes objectives and assessment questions." (Newbooks.lib, 11 September 2014