Herbal Medicines Research
Herausgeber: Liu, Willow J H
Herbal Medicines Research
Herausgeber: Liu, Willow J H
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This book introduces the methodology for collection and identification of herbal materials, extraction and isolation of compounds from herbs, in vitro bioassay, in vivo animal test, toxicology, and clinical trials of herbal research. To fully understand and make the best use of herbal medicines requires the close combination of chemistry, biochemistry, biology, pharmacology, and clinical science. Although there are many books about traditional medicines research, they mostly focus on either chemical or pharmacological study results of certain plants. This book, however, covers the systematic…mehr
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This book introduces the methodology for collection and identification of herbal materials, extraction and isolation of compounds from herbs, in vitro bioassay, in vivo animal test, toxicology, and clinical trials of herbal research. To fully understand and make the best use of herbal medicines requires the close combination of chemistry, biochemistry, biology, pharmacology, and clinical science. Although there are many books about traditional medicines research, they mostly focus on either chemical or pharmacological study results of certain plants. This book, however, covers the systematic study and analysis of herbal medicines in general - including chemical isolation and identification, bioassay and mechanism study, pharmacological experiment, and quality control of the raw plant material and end products.
Produktdetails
- Produktdetails
- Verlag: John Wiley & Sons / Wiley
- Seitenzahl: 488
- Erscheinungstermin: 15. Februar 2011
- Englisch
- Abmessung: 240mm x 161mm x 31mm
- Gewicht: 897g
- ISBN-13: 9780470149362
- ISBN-10: 0470149361
- Artikelnr.: 31199176
- Verlag: John Wiley & Sons / Wiley
- Seitenzahl: 488
- Erscheinungstermin: 15. Februar 2011
- Englisch
- Abmessung: 240mm x 161mm x 31mm
- Gewicht: 897g
- ISBN-13: 9780470149362
- ISBN-10: 0470149361
- Artikelnr.: 31199176
Willow J. H. Liu is the owner of 21st Century Herbs & Health, Inc. Dr. Liu has been working on traditional Chinese herbs and Western herbal medicines for twenty-five years. She has research experience on herbs using the methodologies of modern chemistry, biology, and pharmacology in China, Germany, and the United States. Dr. Liu has also worked in both product development and clinical application of herbal medicines. Her papers on isolation and identification, chemical analysis, bioassay screening, animal studies, and studies of the mechanisms of herbal medicines have been published in different international journals.
Preface. Contributors. Abbreviations. 1. Introduction to Traditional Herbal
Medicines and Their Study (Willow J.H. Liu). 1.1 Definition and Trends of
Traditional Herbal Medicines. 1.2 Research and Development of Herbal
Medicines. 1.3 Common Mistakes Seen in Research on Traditional Herbal
Medicines. 1.4 Research on Traditional Herbs Should Refer to Theories and
Clinical Application of Traditional Medicine. 1.5 Brief Introduction of
Different Systems of Traditional Medicine. 1.6 Regulation of Herbal
Medicines and Their Products. 1.7 Achievements and Challenges of Research
on Chinese Herbal Medicines. References. 2. Collection and Identification
of Raw Herbal Materials (Ping Li, Ling Yi, and Hui-Juan Liu). 2.1
Collection of Herbal Materials. 2.2 Methods for Species Identification of
Herbal Materials. References. 3. Extraction and Isolation of Compounds from
Herbal Medicines (Hong-Wei Liu). 3.1 Compounds in Plants and Their
Structures and Properties. 3.2 Methods for Extraction of Herbal Medicines.
3.3 Methods for Isolation of Compounds from Herbal Extracts. 3.4 An Example
of Extraction and Compound Isolation from Herbal Medicine. References. 4.
Identification and Structure Elucidation of Compounds from Herbal Medicines
(Xin-miao Liang, Yu Jin, Jia-tao Feng, and Yan-xiong Ke). 4.1 Structural
Characteristics and Chemical Identification of Compounds in Herbal
Medicines. 4.2 Brief Introduction of UV, IR, NMR, MS, and other Spectra.
4.3 Identification of Compounds by HPLC and TLC. 4.4 Identification of
Compounds By Spectra. 4.5 Structure Elucidation of Unknown Compounds by
Hyphenated Technique. References. 5. Bioassays for Screening and Functional
Elucidation of Herbal Medicines (Willow J.H. Liu). 5.1 History of Screening
Compounds from Natural Products for Drug Development. 5.2 Brief
Introduction of Enzymes, Receptors, Cells, and Gene Expression. 5.3
Selection of Bioassay. 5.4 Evaluation of Bioassay Results of Herbal
Samples. 5.5 Enzyme Binding Assay. 5.6 Receptor Binding Assay. 5.7 Gene
Expression Assays. 5.8 New Technologies and other Bioassays for Screening
and Mechanism Study. 5.9 Keys to Functional Mechanism Study of Herbal
Medicines. 5.10 Example 1. Screening and Evaluation of Estrogenic Activity
of Herbal Medicines. 5.11 Example 2. Functional Elucidation of Black Cohosh
for Menopause Symptoms. References. 6. Functional Evaluation of Herbal
Medicines by Animal Experiments (Chun-fu Wu, Fang Wang, and Chun-li Li).
6.1 Purposes and Significance of Pharmacological Research for Herbal
Medicines. 6.2 Characteristics of Pharmacological Research of Herbal
Medicines. 6.3 Design of Pharmacological Study on Herbal Medicines. 6.4
Examples of In Vivo Experiments for Herbal Extracts. References. 7. Safety
Pharmacology and Toxicity Study of Herbal Medicines (Jing-yu Yang and
Li-hui Wang). 7.1 Safety Pharmacology. 7.2 Acute Toxicity Study. 7.3
Chronic Toxicity Study. 7.4 Special Toxicity Study. 7.5 Examples of In Vivo
Toxicological Experiments for Compounds or Extracts from Herbal Medicines.
References. 8. Clinical Study of Traditional Herbal Medicine (Hong Yuan,
Guo-ping Yang, and Zhi-jun Huang). 8.1 Introduction to Clinical Trials and
Challenge of Clinical Trials on Herbal Medicines. 8.2 Essential Elements
and Principles of Clinical Trial Design. 8.3 Design of Clinical Trials. 8.4
Examples of Clinical Trials. References. 9. Standardization and Quality
Control of Herbal Extracts and Products (Jian-guo Zeng, Man-liang Tan, Xuan
Peng, and Qi Luo). 9.1 Introduction of QA, QC, and GMP. 9.2
Standardizations and SOP of Herbal Extracts. 9.3 Equipment for Quality
Control of Herbal Extracts and Products. 9.4 Qualitative Analysis of Herbal
Extracts and Products. 9.5 Quantitative Analysis of Herbal Extracts and
Products. References. 10. Understanding Traditional Chinese Medicine and
Chinese Herbs (Willow J.H. Liu). 10.1 Understanding TCM Theories with
Modern Medical Terminology. 10.2 Chemicals are Fundamental Substances Refl
ecting Functions of Chinese Herbs. 10.3 Brief Introduction to the
Properties of Chinese Herbs. 10.4 Modern Pharmacology of Chinese Herbal
Medicine. 10.5 Chinese Herbal Formulas. References. Index.
Medicines and Their Study (Willow J.H. Liu). 1.1 Definition and Trends of
Traditional Herbal Medicines. 1.2 Research and Development of Herbal
Medicines. 1.3 Common Mistakes Seen in Research on Traditional Herbal
Medicines. 1.4 Research on Traditional Herbs Should Refer to Theories and
Clinical Application of Traditional Medicine. 1.5 Brief Introduction of
Different Systems of Traditional Medicine. 1.6 Regulation of Herbal
Medicines and Their Products. 1.7 Achievements and Challenges of Research
on Chinese Herbal Medicines. References. 2. Collection and Identification
of Raw Herbal Materials (Ping Li, Ling Yi, and Hui-Juan Liu). 2.1
Collection of Herbal Materials. 2.2 Methods for Species Identification of
Herbal Materials. References. 3. Extraction and Isolation of Compounds from
Herbal Medicines (Hong-Wei Liu). 3.1 Compounds in Plants and Their
Structures and Properties. 3.2 Methods for Extraction of Herbal Medicines.
3.3 Methods for Isolation of Compounds from Herbal Extracts. 3.4 An Example
of Extraction and Compound Isolation from Herbal Medicine. References. 4.
Identification and Structure Elucidation of Compounds from Herbal Medicines
(Xin-miao Liang, Yu Jin, Jia-tao Feng, and Yan-xiong Ke). 4.1 Structural
Characteristics and Chemical Identification of Compounds in Herbal
Medicines. 4.2 Brief Introduction of UV, IR, NMR, MS, and other Spectra.
4.3 Identification of Compounds by HPLC and TLC. 4.4 Identification of
Compounds By Spectra. 4.5 Structure Elucidation of Unknown Compounds by
Hyphenated Technique. References. 5. Bioassays for Screening and Functional
Elucidation of Herbal Medicines (Willow J.H. Liu). 5.1 History of Screening
Compounds from Natural Products for Drug Development. 5.2 Brief
Introduction of Enzymes, Receptors, Cells, and Gene Expression. 5.3
Selection of Bioassay. 5.4 Evaluation of Bioassay Results of Herbal
Samples. 5.5 Enzyme Binding Assay. 5.6 Receptor Binding Assay. 5.7 Gene
Expression Assays. 5.8 New Technologies and other Bioassays for Screening
and Mechanism Study. 5.9 Keys to Functional Mechanism Study of Herbal
Medicines. 5.10 Example 1. Screening and Evaluation of Estrogenic Activity
of Herbal Medicines. 5.11 Example 2. Functional Elucidation of Black Cohosh
for Menopause Symptoms. References. 6. Functional Evaluation of Herbal
Medicines by Animal Experiments (Chun-fu Wu, Fang Wang, and Chun-li Li).
6.1 Purposes and Significance of Pharmacological Research for Herbal
Medicines. 6.2 Characteristics of Pharmacological Research of Herbal
Medicines. 6.3 Design of Pharmacological Study on Herbal Medicines. 6.4
Examples of In Vivo Experiments for Herbal Extracts. References. 7. Safety
Pharmacology and Toxicity Study of Herbal Medicines (Jing-yu Yang and
Li-hui Wang). 7.1 Safety Pharmacology. 7.2 Acute Toxicity Study. 7.3
Chronic Toxicity Study. 7.4 Special Toxicity Study. 7.5 Examples of In Vivo
Toxicological Experiments for Compounds or Extracts from Herbal Medicines.
References. 8. Clinical Study of Traditional Herbal Medicine (Hong Yuan,
Guo-ping Yang, and Zhi-jun Huang). 8.1 Introduction to Clinical Trials and
Challenge of Clinical Trials on Herbal Medicines. 8.2 Essential Elements
and Principles of Clinical Trial Design. 8.3 Design of Clinical Trials. 8.4
Examples of Clinical Trials. References. 9. Standardization and Quality
Control of Herbal Extracts and Products (Jian-guo Zeng, Man-liang Tan, Xuan
Peng, and Qi Luo). 9.1 Introduction of QA, QC, and GMP. 9.2
Standardizations and SOP of Herbal Extracts. 9.3 Equipment for Quality
Control of Herbal Extracts and Products. 9.4 Qualitative Analysis of Herbal
Extracts and Products. 9.5 Quantitative Analysis of Herbal Extracts and
Products. References. 10. Understanding Traditional Chinese Medicine and
Chinese Herbs (Willow J.H. Liu). 10.1 Understanding TCM Theories with
Modern Medical Terminology. 10.2 Chemicals are Fundamental Substances Refl
ecting Functions of Chinese Herbs. 10.3 Brief Introduction to the
Properties of Chinese Herbs. 10.4 Modern Pharmacology of Chinese Herbal
Medicine. 10.5 Chinese Herbal Formulas. References. Index.
Preface. Contributors. Abbreviations. 1. Introduction to Traditional Herbal
Medicines and Their Study (Willow J.H. Liu). 1.1 Definition and Trends of
Traditional Herbal Medicines. 1.2 Research and Development of Herbal
Medicines. 1.3 Common Mistakes Seen in Research on Traditional Herbal
Medicines. 1.4 Research on Traditional Herbs Should Refer to Theories and
Clinical Application of Traditional Medicine. 1.5 Brief Introduction of
Different Systems of Traditional Medicine. 1.6 Regulation of Herbal
Medicines and Their Products. 1.7 Achievements and Challenges of Research
on Chinese Herbal Medicines. References. 2. Collection and Identification
of Raw Herbal Materials (Ping Li, Ling Yi, and Hui-Juan Liu). 2.1
Collection of Herbal Materials. 2.2 Methods for Species Identification of
Herbal Materials. References. 3. Extraction and Isolation of Compounds from
Herbal Medicines (Hong-Wei Liu). 3.1 Compounds in Plants and Their
Structures and Properties. 3.2 Methods for Extraction of Herbal Medicines.
3.3 Methods for Isolation of Compounds from Herbal Extracts. 3.4 An Example
of Extraction and Compound Isolation from Herbal Medicine. References. 4.
Identification and Structure Elucidation of Compounds from Herbal Medicines
(Xin-miao Liang, Yu Jin, Jia-tao Feng, and Yan-xiong Ke). 4.1 Structural
Characteristics and Chemical Identification of Compounds in Herbal
Medicines. 4.2 Brief Introduction of UV, IR, NMR, MS, and other Spectra.
4.3 Identification of Compounds by HPLC and TLC. 4.4 Identification of
Compounds By Spectra. 4.5 Structure Elucidation of Unknown Compounds by
Hyphenated Technique. References. 5. Bioassays for Screening and Functional
Elucidation of Herbal Medicines (Willow J.H. Liu). 5.1 History of Screening
Compounds from Natural Products for Drug Development. 5.2 Brief
Introduction of Enzymes, Receptors, Cells, and Gene Expression. 5.3
Selection of Bioassay. 5.4 Evaluation of Bioassay Results of Herbal
Samples. 5.5 Enzyme Binding Assay. 5.6 Receptor Binding Assay. 5.7 Gene
Expression Assays. 5.8 New Technologies and other Bioassays for Screening
and Mechanism Study. 5.9 Keys to Functional Mechanism Study of Herbal
Medicines. 5.10 Example 1. Screening and Evaluation of Estrogenic Activity
of Herbal Medicines. 5.11 Example 2. Functional Elucidation of Black Cohosh
for Menopause Symptoms. References. 6. Functional Evaluation of Herbal
Medicines by Animal Experiments (Chun-fu Wu, Fang Wang, and Chun-li Li).
6.1 Purposes and Significance of Pharmacological Research for Herbal
Medicines. 6.2 Characteristics of Pharmacological Research of Herbal
Medicines. 6.3 Design of Pharmacological Study on Herbal Medicines. 6.4
Examples of In Vivo Experiments for Herbal Extracts. References. 7. Safety
Pharmacology and Toxicity Study of Herbal Medicines (Jing-yu Yang and
Li-hui Wang). 7.1 Safety Pharmacology. 7.2 Acute Toxicity Study. 7.3
Chronic Toxicity Study. 7.4 Special Toxicity Study. 7.5 Examples of In Vivo
Toxicological Experiments for Compounds or Extracts from Herbal Medicines.
References. 8. Clinical Study of Traditional Herbal Medicine (Hong Yuan,
Guo-ping Yang, and Zhi-jun Huang). 8.1 Introduction to Clinical Trials and
Challenge of Clinical Trials on Herbal Medicines. 8.2 Essential Elements
and Principles of Clinical Trial Design. 8.3 Design of Clinical Trials. 8.4
Examples of Clinical Trials. References. 9. Standardization and Quality
Control of Herbal Extracts and Products (Jian-guo Zeng, Man-liang Tan, Xuan
Peng, and Qi Luo). 9.1 Introduction of QA, QC, and GMP. 9.2
Standardizations and SOP of Herbal Extracts. 9.3 Equipment for Quality
Control of Herbal Extracts and Products. 9.4 Qualitative Analysis of Herbal
Extracts and Products. 9.5 Quantitative Analysis of Herbal Extracts and
Products. References. 10. Understanding Traditional Chinese Medicine and
Chinese Herbs (Willow J.H. Liu). 10.1 Understanding TCM Theories with
Modern Medical Terminology. 10.2 Chemicals are Fundamental Substances Refl
ecting Functions of Chinese Herbs. 10.3 Brief Introduction to the
Properties of Chinese Herbs. 10.4 Modern Pharmacology of Chinese Herbal
Medicine. 10.5 Chinese Herbal Formulas. References. Index.
Medicines and Their Study (Willow J.H. Liu). 1.1 Definition and Trends of
Traditional Herbal Medicines. 1.2 Research and Development of Herbal
Medicines. 1.3 Common Mistakes Seen in Research on Traditional Herbal
Medicines. 1.4 Research on Traditional Herbs Should Refer to Theories and
Clinical Application of Traditional Medicine. 1.5 Brief Introduction of
Different Systems of Traditional Medicine. 1.6 Regulation of Herbal
Medicines and Their Products. 1.7 Achievements and Challenges of Research
on Chinese Herbal Medicines. References. 2. Collection and Identification
of Raw Herbal Materials (Ping Li, Ling Yi, and Hui-Juan Liu). 2.1
Collection of Herbal Materials. 2.2 Methods for Species Identification of
Herbal Materials. References. 3. Extraction and Isolation of Compounds from
Herbal Medicines (Hong-Wei Liu). 3.1 Compounds in Plants and Their
Structures and Properties. 3.2 Methods for Extraction of Herbal Medicines.
3.3 Methods for Isolation of Compounds from Herbal Extracts. 3.4 An Example
of Extraction and Compound Isolation from Herbal Medicine. References. 4.
Identification and Structure Elucidation of Compounds from Herbal Medicines
(Xin-miao Liang, Yu Jin, Jia-tao Feng, and Yan-xiong Ke). 4.1 Structural
Characteristics and Chemical Identification of Compounds in Herbal
Medicines. 4.2 Brief Introduction of UV, IR, NMR, MS, and other Spectra.
4.3 Identification of Compounds by HPLC and TLC. 4.4 Identification of
Compounds By Spectra. 4.5 Structure Elucidation of Unknown Compounds by
Hyphenated Technique. References. 5. Bioassays for Screening and Functional
Elucidation of Herbal Medicines (Willow J.H. Liu). 5.1 History of Screening
Compounds from Natural Products for Drug Development. 5.2 Brief
Introduction of Enzymes, Receptors, Cells, and Gene Expression. 5.3
Selection of Bioassay. 5.4 Evaluation of Bioassay Results of Herbal
Samples. 5.5 Enzyme Binding Assay. 5.6 Receptor Binding Assay. 5.7 Gene
Expression Assays. 5.8 New Technologies and other Bioassays for Screening
and Mechanism Study. 5.9 Keys to Functional Mechanism Study of Herbal
Medicines. 5.10 Example 1. Screening and Evaluation of Estrogenic Activity
of Herbal Medicines. 5.11 Example 2. Functional Elucidation of Black Cohosh
for Menopause Symptoms. References. 6. Functional Evaluation of Herbal
Medicines by Animal Experiments (Chun-fu Wu, Fang Wang, and Chun-li Li).
6.1 Purposes and Significance of Pharmacological Research for Herbal
Medicines. 6.2 Characteristics of Pharmacological Research of Herbal
Medicines. 6.3 Design of Pharmacological Study on Herbal Medicines. 6.4
Examples of In Vivo Experiments for Herbal Extracts. References. 7. Safety
Pharmacology and Toxicity Study of Herbal Medicines (Jing-yu Yang and
Li-hui Wang). 7.1 Safety Pharmacology. 7.2 Acute Toxicity Study. 7.3
Chronic Toxicity Study. 7.4 Special Toxicity Study. 7.5 Examples of In Vivo
Toxicological Experiments for Compounds or Extracts from Herbal Medicines.
References. 8. Clinical Study of Traditional Herbal Medicine (Hong Yuan,
Guo-ping Yang, and Zhi-jun Huang). 8.1 Introduction to Clinical Trials and
Challenge of Clinical Trials on Herbal Medicines. 8.2 Essential Elements
and Principles of Clinical Trial Design. 8.3 Design of Clinical Trials. 8.4
Examples of Clinical Trials. References. 9. Standardization and Quality
Control of Herbal Extracts and Products (Jian-guo Zeng, Man-liang Tan, Xuan
Peng, and Qi Luo). 9.1 Introduction of QA, QC, and GMP. 9.2
Standardizations and SOP of Herbal Extracts. 9.3 Equipment for Quality
Control of Herbal Extracts and Products. 9.4 Qualitative Analysis of Herbal
Extracts and Products. 9.5 Quantitative Analysis of Herbal Extracts and
Products. References. 10. Understanding Traditional Chinese Medicine and
Chinese Herbs (Willow J.H. Liu). 10.1 Understanding TCM Theories with
Modern Medical Terminology. 10.2 Chemicals are Fundamental Substances Refl
ecting Functions of Chinese Herbs. 10.3 Brief Introduction to the
Properties of Chinese Herbs. 10.4 Modern Pharmacology of Chinese Herbal
Medicine. 10.5 Chinese Herbal Formulas. References. Index.