This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process - including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how…mehr
This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process - including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.
DARRELL R. BOVERHOF, PhD, is a Senior Toxicology Specialist at The Dow Chemical Company where he leads research programs on respiratory allergy and sensitization, nanotoxicology, and toxicogenomics. Dr. Boverhof has authored or coauthored numerous peer-reviewed publications, review articles, and book chapters in the area of toxicogenomics and serves on the editorial board of the journal Toxicological Sciences. B. BHASKAR GOLLAPUDI, PhD, is the Scientific Director of Mammalian Toxicology at The Dow Chemical Company's Global Toxicology & Environmental Research Laboratory. Dr. Gollapudi has authored or co-authored more than 80 scientific publications. He is an Associate Editor of the journal Toxicological Sciences and is currently serving as an adjunct Associate Professor of Toxicology in the Department of Public Health at the University of Michigan.
Inhaltsangabe
PREFACE. CONTRIBUTORS. 1 TOXICOLOGY "OMICS" TECHNOLOGIES AND TOXICOGENOMICS: A PRIMER (Darrell R. Boverhof and B. Bhaskar Gollapudi). 2 INTRODUCTION TO HUMAN HEALTH RISK ASSESSMENT (Irene Baskerville-Abraham Alison Willis Bernard Gadagbui and Lynne T. Haber). 3 PRACTICAL CONSIDERATIONS FOR THE APPLICATION OF TOXICOGENOMICS TO RISK ASSESSMENT: EARLY EXPERIENCE CURRENT DRIVERS AND A PATH FORWARD (Darrell R. Boverhof David R. Geter B. Bhaskar Gollapudi and Heli Hollnagel). 4 APPROACHES AND PRACTICAL CONSIDERATIONS FOR THE ANALYSIS OF TOXICOGENOMICS DATA (Zhenqiang Su Hong Fang Weida Tong Huixiao Hong Roger Perkins and Leming Shi). 5 GENOMICS IN IDENTIFYING MUTAGENIC MODE OF ACTION IN CARCINOGENESIS (Jiri Aubrecht and Ebru Caba). 6 APPLICATION OF GENOMICS FOR PREDICTING AND UNDERSTANDING THE MODE OF ACTION FOR NONGENOTOXIC CARCINOGENS (Mark R. Fielden). 7 GENOMICS IN CHARACTERIZING ENDOCRINE TOXICITY (Jorge M. Naciff and George P. Daston). 8 STUDYING ORGAN-SPECIFIC TOXICITY USING GENE-EXPRESSION PROFILING (M. Ann Mongan and Hisham K. Hamadeh). 9 TOXICOGENOMIC STUDIES IN HUMAN POPULATIONS (Cliona M. McHale Luoping Zhang Alan E. Hubbard and Martyn T. Smith). 10 TOXICOGENOMICS APPLIED TO ECOLOGICAL RISK ASSESSMENT (Daniel L. Villeneuve Dalma Martinovi¿c and Gerald T. Ankley). 11 ANALYSIS OF TRANSCRIPTOMIC DOSE-RESPONSE DATA FOR TOXICOLOGY AND RISK ASSESSMENT (Russell S. Thomas Longlong Yang Harvey J. Clewell and Melvin E. Andersen). 12 TOXICOGENOMICS AS A TOOL FOR VALIDATING ANIMAL TO HUMAN EXTRAPOLATIONS IN CHEMICAL RISK ASSESSMENT: CONCEPTS APPLICATIONS AND CHALLENGES (Alan Dombkowski and J. Craig Rowlands). 13 TOXICOGENOMICS AND ANIMAL ALTERNATIVES (Anne S. Kienhuis Joost H. M. van Delft and Jos C. S. Kleinjans). 14 TOXICOGENOMICS AND THE REGULATORY FRAMEWORK (Kathryn Gallagher Federico M. Goodsaid David J. Dix Susan Y. Euling Melissa Kramer Nancy E. McCarroll Julian R. Preston Philip G. Sayre Banalata Sen Douglas C. Wolf and William H. Benson). 15 STANDARDIZATION OF GENE-EXPRESSION INFORMATION FOR THE SAFETY EVALUATION: ACTIVITIES IN JAPAN (Ken-ichi Aisaki and Jun Kanno). 16 APPLYING TRANSCRIPTIONAL PROFILING IN DRUG SAFETY EVALUATION (Lois D. Lehman-McKeeman and William R. Foster). 17 REFRAMING THE RISK ASSESSMENT PARADIGM: TOWARD A SYSTEMS BIOLOGY APPROACH (Sarah N. Campion and Kim Boekelheide). INDEX.
PREFACE. CONTRIBUTORS. 1 TOXICOLOGY "OMICS" TECHNOLOGIES AND TOXICOGENOMICS: A PRIMER (Darrell R. Boverhof and B. Bhaskar Gollapudi). 2 INTRODUCTION TO HUMAN HEALTH RISK ASSESSMENT (Irene Baskerville-Abraham Alison Willis Bernard Gadagbui and Lynne T. Haber). 3 PRACTICAL CONSIDERATIONS FOR THE APPLICATION OF TOXICOGENOMICS TO RISK ASSESSMENT: EARLY EXPERIENCE CURRENT DRIVERS AND A PATH FORWARD (Darrell R. Boverhof David R. Geter B. Bhaskar Gollapudi and Heli Hollnagel). 4 APPROACHES AND PRACTICAL CONSIDERATIONS FOR THE ANALYSIS OF TOXICOGENOMICS DATA (Zhenqiang Su Hong Fang Weida Tong Huixiao Hong Roger Perkins and Leming Shi). 5 GENOMICS IN IDENTIFYING MUTAGENIC MODE OF ACTION IN CARCINOGENESIS (Jiri Aubrecht and Ebru Caba). 6 APPLICATION OF GENOMICS FOR PREDICTING AND UNDERSTANDING THE MODE OF ACTION FOR NONGENOTOXIC CARCINOGENS (Mark R. Fielden). 7 GENOMICS IN CHARACTERIZING ENDOCRINE TOXICITY (Jorge M. Naciff and George P. Daston). 8 STUDYING ORGAN-SPECIFIC TOXICITY USING GENE-EXPRESSION PROFILING (M. Ann Mongan and Hisham K. Hamadeh). 9 TOXICOGENOMIC STUDIES IN HUMAN POPULATIONS (Cliona M. McHale Luoping Zhang Alan E. Hubbard and Martyn T. Smith). 10 TOXICOGENOMICS APPLIED TO ECOLOGICAL RISK ASSESSMENT (Daniel L. Villeneuve Dalma Martinovi¿c and Gerald T. Ankley). 11 ANALYSIS OF TRANSCRIPTOMIC DOSE-RESPONSE DATA FOR TOXICOLOGY AND RISK ASSESSMENT (Russell S. Thomas Longlong Yang Harvey J. Clewell and Melvin E. Andersen). 12 TOXICOGENOMICS AS A TOOL FOR VALIDATING ANIMAL TO HUMAN EXTRAPOLATIONS IN CHEMICAL RISK ASSESSMENT: CONCEPTS APPLICATIONS AND CHALLENGES (Alan Dombkowski and J. Craig Rowlands). 13 TOXICOGENOMICS AND ANIMAL ALTERNATIVES (Anne S. Kienhuis Joost H. M. van Delft and Jos C. S. Kleinjans). 14 TOXICOGENOMICS AND THE REGULATORY FRAMEWORK (Kathryn Gallagher Federico M. Goodsaid David J. Dix Susan Y. Euling Melissa Kramer Nancy E. McCarroll Julian R. Preston Philip G. Sayre Banalata Sen Douglas C. Wolf and William H. Benson). 15 STANDARDIZATION OF GENE-EXPRESSION INFORMATION FOR THE SAFETY EVALUATION: ACTIVITIES IN JAPAN (Ken-ichi Aisaki and Jun Kanno). 16 APPLYING TRANSCRIPTIONAL PROFILING IN DRUG SAFETY EVALUATION (Lois D. Lehman-McKeeman and William R. Foster). 17 REFRAMING THE RISK ASSESSMENT PARADIGM: TOWARD A SYSTEMS BIOLOGY APPROACH (Sarah N. Campion and Kim Boekelheide). INDEX.
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