CDH13 gene polymorphism and metabolic syndrome in Gambian population - Bojang, Kebba S.;Lyrawati, Diana;Sujuti, Hidayat
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Polymorphism in CDH13 gene, which encodes for the adiponectin receptor, T-cadherin, is a genetic risk factor associated with metabolic syndrome; which is a complex syndrome with clustering of multiple cardiovascular risk factors. CDH13 rs3865188, which is found in the promoter region of the CDH13 gene, has been found to be associated with metabolic syndrome and its traits in Asian and European Caucasian populations. In this work, we investigated the association of CHD13 rs3865188 and metabolic syndrome in an African population (Gambian population) for the first time. CDH13 rs3865188 was…mehr

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Produktbeschreibung
Polymorphism in CDH13 gene, which encodes for the adiponectin receptor, T-cadherin, is a genetic risk factor associated with metabolic syndrome; which is a complex syndrome with clustering of multiple cardiovascular risk factors. CDH13 rs3865188, which is found in the promoter region of the CDH13 gene, has been found to be associated with metabolic syndrome and its traits in Asian and European Caucasian populations. In this work, we investigated the association of CHD13 rs3865188 and metabolic syndrome in an African population (Gambian population) for the first time. CDH13 rs3865188 was genotyped using PCR master mix and sequencing. Blood sugar, triglyceride and high-density lipoprotein levels- biochemical parameters of metabolic syndrome-were determined by standard clinical laboratory methods. The results demonstrated significant association between CDH13 rs385618 and metabolic syndrome in an African population for the first time. We also found genotypes CC and CA in CHD13 rs3865188 for the first time.
Autorenporträt
Kebba S. Bojang, MD, PhD, arbeitete als Kliniker in den Abteilungen für Innere Medizin am Edward Francis Small Teaching Hospital und am Kanifing General Hospital sowie als Dozent an der School of Medicine and Allied Health Sciences der Universität von Gambia. Er ist auch Dichter und Essayist und hat zwei Gedichtbände veröffentlicht.