This book describes recent progress in enzyme-driven green syntheses of industrially important molecules. The first three introductory chapters overview recent technological advances in enzymes and cell-based transformations, and green chemistry metrics for synthetic efficiency. The remaining chapters are directed to case studies in biotechnological production of pharmaceuticals (small molecules, natural products and biologics), flavors, fragrance and cosmetics, fine chemicals, value-added chemicals from glucose and biomass, and polymeric materials. The book is aimed to facilitate the…mehr
This book describes recent progress in enzyme-driven green syntheses of industrially important molecules. The first three introductory chapters overview recent technological advances in enzymes and cell-based transformations, and green chemistry metrics for synthetic efficiency. The remaining chapters are directed to case studies in biotechnological production of pharmaceuticals (small molecules, natural products and biologics), flavors, fragrance and cosmetics, fine chemicals, value-added chemicals from glucose and biomass, and polymeric materials.
The book is aimed to facilitate the industrial applications of this powerful and emerging green technology, and catalyze the advancement of the technology itself.
JUNHUA (Alex) TAO is currently CEO of Metabomics, Inc. Prior to that; he was the CSO of Elevance Renewable Sciences, and the creator and head of the Biotransformations Group at Pfizer, where he was also a core member of the API Development Team. He co-authored over 60 publications including "Biocatalysis for the Pharmaceutical Industry" (Wiley, 2009) and co-invented over 20 patents. In addition, he was the recipient of the Pfizer Achievement Award, the Pfizer Green Chemistry Award, and a key member of the Lyrica process development team, which won the IChemE Award for Excellence in Green Chemistry and Engineering (2006). ROMAS JOSEPH KAZLAUSKAS is Professor of Biochemistry, Molecular Biology and Biophysics at the BioTechnology Institute of the University of Minnesota, Twin Cities. He is the coauthor of over eighty papers and reviews, and the book Hydrolases in Organic Synthesis. He also served as the co-chair of two Gordon Research Conferences, one on biocatalysis and one on green chemistry.
Inhaltsangabe
Contributors vii Preface xi Part I. Introduction Chapters 1 1. Biotechnology Tools for Green Synthesis: Enzymes, Metabolic Pathways, and Their Improvement by Engineering 3 2. How Green Can the Industry Become with Biotechnology? 23 3. Emerging Enzymes and Their Synthetic Applications 45 4. Reaction Efficiencies and Green Chemistry Metrics of Biotransformations 67 Part II. Application and Case Studies-Pharmaceuticals and Fine Chemicals 89 5. Biocatalytic Routes to Chiral Intermediates for Development of Drugs 91 6. Transglutaminase for Protein Drug Modification: Pegylation and Beyond 151 7. Microbial Production of Plant-Derived Pharmaceutical Natural Products Through Metabolic Engineering: Artemisinin and Beyond 173 8. Toward Greener Therapeutic Proteins 197 Part III. Application and Case Studies-Flavor & Fragrance, Agrochemicals and Fine Chemicals 221 9. Opportunities for Biocatalysis in the Flavor, Fragrance, and Cosmetic Industry 223 10. Application of Biocatalysis in the Agrochemical Industry 255 11. Green Porduction of Fine Chemicals by Isolated Enzymes 277 12. Whole Cell Production of Fine Chemicals and Intermediates 299 Part IV. Application and Case Studies-Polymers and Renewable Chemicals 327 13. Green Chemistry for the Production of Biodegradable, Biorenewable, Biocompatible, and Polymers 329 14. Enzymatic Degradation of Lignocellulosic Biomass 361 15. Bioconversion of Nenewables-Plant Oils 391 16. Microbial Bioprocesses for industrial-Scale Chemical Production 429 Index 469
Contributors vii Preface xi Part I. Introduction Chapters 1 1. Biotechnology Tools for Green Synthesis: Enzymes, Metabolic Pathways, and Their Improvement by Engineering 3 2. How Green Can the Industry Become with Biotechnology? 23 3. Emerging Enzymes and Their Synthetic Applications 45 4. Reaction Efficiencies and Green Chemistry Metrics of Biotransformations 67 Part II. Application and Case Studies-Pharmaceuticals and Fine Chemicals 89 5. Biocatalytic Routes to Chiral Intermediates for Development of Drugs 91 6. Transglutaminase for Protein Drug Modification: Pegylation and Beyond 151 7. Microbial Production of Plant-Derived Pharmaceutical Natural Products Through Metabolic Engineering: Artemisinin and Beyond 173 8. Toward Greener Therapeutic Proteins 197 Part III. Application and Case Studies-Flavor & Fragrance, Agrochemicals and Fine Chemicals 221 9. Opportunities for Biocatalysis in the Flavor, Fragrance, and Cosmetic Industry 223 10. Application of Biocatalysis in the Agrochemical Industry 255 11. Green Porduction of Fine Chemicals by Isolated Enzymes 277 12. Whole Cell Production of Fine Chemicals and Intermediates 299 Part IV. Application and Case Studies-Polymers and Renewable Chemicals 327 13. Green Chemistry for the Production of Biodegradable, Biorenewable, Biocompatible, and Polymers 329 14. Enzymatic Degradation of Lignocellulosic Biomass 361 15. Bioconversion of Nenewables-Plant Oils 391 16. Microbial Bioprocesses for industrial-Scale Chemical Production 429 Index 469
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