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This Antimicrobial Prescribing and Stewardship Issue (volume 1) consist of manuscripts, including original research, review articles, case series, and opinion papers for topics related to antimicrobial (antibiotic, antifungal) stewardship, including: Disease-based/organism-based antimicrobial stewardship; Diagnostic stewardship; Influence of antimicrobial utilisation changes in antimicrobial resistance; Impact of antimicrobial stewardship on quality performance measures and patient outcomes; Novel antimicrobial stewardship education and training approaches or interventions aimed at the public and/or healthcare workers; Behavioural change approaches to antimicrobial stewardship; Collaborative practice agreements in antimicrobial stewardship; Antimicrobial stewardship in special populations (e.g., paediatrics, geriatrics, emergency medicine, hematology/oncology); Tackling AMR through antimicrobial stewardship in low- and middle-income countries; Antimicrobial stewardship for animal health; Antimicrobial stewardship in alternative settings (e.g., community practice, long-term care, and resource-limited small and rural hospitals); Antimicrobial use and stewardship in the context of the COVID-19 pandemic; Global collaborations to tackle AMR through antimicrobial stewardship.