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This comprehensive text provides a detailed overview of the molecular mechanisms underpinning the development of cancer and its treatment. Written by an international panel of researchers, specialists and practitioners in the field, the text discusses all aspects of cancer biology from the causes, development and diagnosis through to the treatment of cancer. The text offers in-depth coverage of traditional areas of study, while also discussing areas of controversy and emerging importance and highlighting future directions for research.
This comprehensive text provides a detailed overview of the molecular mechanisms underpinning the development of cancer and its treatment. Written by an international panel of researchers, specialists and practitioners in the field, the text discusses all aspects of cancer biology from the causes, development and diagnosis through to the treatment of cancer. The text offers in-depth coverage of traditional areas of study, while also discussing areas of controversy and emerging importance and highlighting future directions for research.
Stella Pelengaris Ph.D is Director of Pharmalogos and previous Researcher at the Imperial Cancer Research Fund, and Senior Research Fellow at the University of Warwick and Warwick Medical School. Mike Khan Ph.D FRCP is Associate Professor of Medicine at University Hospitals of Coventry and Warwickshire and previous Head of Molecular Medicine at the University of Warwick.
Inhaltsangabe
Contributors vii Preface to the Second Edition ix Reviews of the First Edition x Acknowledgments and Dedication xi About the Companion Website xii Introduction 1 1 Overview of Cancer Biology 3 Michael Khan and Stella Pelengaris 2 The Burden of Cancer 43 William P. Steward and Anne L. Thomas 3 Nature and Nurture in Oncogenesis 67 Michael Khan and Stella Pelengaris 4 DNA Replication and the Cell Cycle 111 Stella Pelengaris and Michael Khan 5 Growth Signaling Pathways and the New Era of Targeted Treatment of Cancer 146 Stella Pelengaris and Michael Khan 6 Oncogenes 188 Stella Pelengaris and Michael Khan 7 Tumor Suppressors 239 Martine F. Roussel 8 Cell Death 266 Stella Pelengaris and Michael Khan 9 Senescence Telomeres and Cancer Stem Cells 295 Maria A. Blasco and Michael Khan 10 Genetic Instability Chromosomes and Repair 314 Michael Khan 11 There Is More to Cancer than Genetics: Regulation of Gene and Protein Expression by Epigenetic Factors Small Regulatory RNAs and Protein Stability 350 Stella Pelengaris and Michael Khan 12 Cell Adhesion in Cancer 383 Charles H. Streuli 13 Tumor Immunity and Immunotherapy 410 Cassian Yee 14 Tumor Angiogenesis 429 Christiana Ruhrberg 15 Cancer Chemistry: Designing New Drugs for Cancer Treatment 438 Ana M. Pizarro and Peter J. Sadler 16 Biologically Targeted Agents from Bench to Bedside 461 Michael Khan Peter Sadler Ana M. Pizarro and Stella Pelengaris 17 The Diagnosis of Cancer 509 Anne L. Thomas Bruno Morgan and William P. Steward 18 Treatment of Cancer: Chemotherapy and Radiotherapy 526 Anne L. Thomas J.P. Sage and William P. Steward 19 Caring for the Cancer Patient 544 Nicky Rudd and Esther Waterhouse 20 Systems Biology of Cancer 554 Walter Schubert Norbert C.J. de Wit and Peter Walden Glossary 585 Answers to Questions 597 Index 603
Contributors vii Preface to the Second Edition ix Reviews of the First Edition x Acknowledgments and Dedication xi About the Companion Website xii Introduction 1 1 Overview of Cancer Biology 3 Michael Khan and Stella Pelengaris 2 The Burden of Cancer 43 William P. Steward and Anne L. Thomas 3 Nature and Nurture in Oncogenesis 67 Michael Khan and Stella Pelengaris 4 DNA Replication and the Cell Cycle 111 Stella Pelengaris and Michael Khan 5 Growth Signaling Pathways and the New Era of Targeted Treatment of Cancer 146 Stella Pelengaris and Michael Khan 6 Oncogenes 188 Stella Pelengaris and Michael Khan 7 Tumor Suppressors 239 Martine F. Roussel 8 Cell Death 266 Stella Pelengaris and Michael Khan 9 Senescence Telomeres and Cancer Stem Cells 295 Maria A. Blasco and Michael Khan 10 Genetic Instability Chromosomes and Repair 314 Michael Khan 11 There Is More to Cancer than Genetics: Regulation of Gene and Protein Expression by Epigenetic Factors Small Regulatory RNAs and Protein Stability 350 Stella Pelengaris and Michael Khan 12 Cell Adhesion in Cancer 383 Charles H. Streuli 13 Tumor Immunity and Immunotherapy 410 Cassian Yee 14 Tumor Angiogenesis 429 Christiana Ruhrberg 15 Cancer Chemistry: Designing New Drugs for Cancer Treatment 438 Ana M. Pizarro and Peter J. Sadler 16 Biologically Targeted Agents from Bench to Bedside 461 Michael Khan Peter Sadler Ana M. Pizarro and Stella Pelengaris 17 The Diagnosis of Cancer 509 Anne L. Thomas Bruno Morgan and William P. Steward 18 Treatment of Cancer: Chemotherapy and Radiotherapy 526 Anne L. Thomas J.P. Sage and William P. Steward 19 Caring for the Cancer Patient 544 Nicky Rudd and Esther Waterhouse 20 Systems Biology of Cancer 554 Walter Schubert Norbert C.J. de Wit and Peter Walden Glossary 585 Answers to Questions 597 Index 603
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