Die erste umfassende Abhandlung über Chemie und biologische Aktivität der Aminophosphin- und -phosphonsäuren einschließlich ihrer Derivate (Ester und Peptide)! Der Schwerpunkt liegt auf der anwendungsorientierten agrochemischen und biomedizinischen Forschung, beispielsweise im Hinblick auf die Inhibition von Proteasen. Ausführlich diskutiert wird die enantioselektive Synthese der Verbindungen. Mit vielen spektroskopischen und Strukturdaten.
Die erste umfassende Abhandlung über Chemie und biologische Aktivität der Aminophosphin- und -phosphonsäuren einschließlich ihrer Derivate (Ester und Peptide)! Der Schwerpunkt liegt auf der anwendungsorientierten agrochemischen und biomedizinischen Forschung, beispielsweise im Hinblick auf die Inhibition von Proteasen. Ausführlich diskutiert wird die enantioselektive Synthese der Verbindungen. Mit vielen spektroskopischen und Strukturdaten.
Valery P. Kukhar is the author of Aminophosphonic and Aminophosphinic Acids: Chemistry and Biological Activity, published by Wiley. Harry R. Hudson is the author of Aminophosphonic and Aminophosphinic Acids: Chemistry and Biological Activity, published by Wiley.
Inhaltsangabe
Naturally Occurring Aminophosphonic and Aminophosphinic Acids (P. Mastalerz & P. Kafarski). Synthesis of -Aminoalkanephosphonic and -Aminoalkanephosphinic Acids (P. Kafarski & J. Zo). Synthesis of Aminoalkanephosphonic and Aminoalkanephosphinic Acids with the Amino Substituent in Other than the -Position (V. Kukhar). -Amino Acid Analogues Bearing Side-Chain C-P Linkages (S. Lall and R. Engel). Asymmetric Synthesis of Aminophosphonic and Aminophosphinic Acids (V. Kukhar). Synthesis of Phosphono- and Phosphinopeptides (P. Kafarski & B. Lejczak). Column Chromatography of Aminophosphonic Acids and Phosphonopeptides (S. Galushko). Physical Properties and NMR-Spectroscopic Characterization of Aminophosphonates and Aminophosphinates (G. Hägele). Structure and Stability Constants of Metal Complexes in Solution (T. Kiss & I. Lázár). X-Ray Crystallographic Studies (N. Choi & M. McPartlin). Mass Spectrometry and Gas Chromatography-Mass Spectrometry of Aminoalkanephosphonic Acids (Z. Kudzin & M. Sochaki). The Biological Activity of Phosphono- and Phosphinopeptides (P. Kafarski & B. Lejezak). Aminophosphonic and Aminophosphinic Acids and their Derivatives as Agrochemicals (H. Hudson). Neuroactive Aminophosphonic and Aminophosphinic Acid Derivatives (D. Jane). Aminophosphonic and Aminophosphinic Acid Derivatives in the Design of Transition State Analogue Inhibitors: Biomedical Opportunities and Limitations (J. Oleksyszyn). Aminophosphonic and Aminophosphinic Acids in the Design and Synthesis of HIV Protease Inhibitors (A. Peyman). Aminophosphonic Acid Derivatives as Antithrombotic Agents (D. Green, et al.). Aminophosphonic and Aminophosphinic Acid Derivatives as Inhibitors of Human Collagenase (R. Markwell). Index.
Naturally Occurring Aminophosphonic and Aminophosphinic Acids (P. Mastalerz & P. Kafarski). Synthesis of -Aminoalkanephosphonic and -Aminoalkanephosphinic Acids (P. Kafarski & J. Zo). Synthesis of Aminoalkanephosphonic and Aminoalkanephosphinic Acids with the Amino Substituent in Other than the -Position (V. Kukhar). -Amino Acid Analogues Bearing Side-Chain C-P Linkages (S. Lall and R. Engel). Asymmetric Synthesis of Aminophosphonic and Aminophosphinic Acids (V. Kukhar). Synthesis of Phosphono- and Phosphinopeptides (P. Kafarski & B. Lejczak). Column Chromatography of Aminophosphonic Acids and Phosphonopeptides (S. Galushko). Physical Properties and NMR-Spectroscopic Characterization of Aminophosphonates and Aminophosphinates (G. Hägele). Structure and Stability Constants of Metal Complexes in Solution (T. Kiss & I. Lázár). X-Ray Crystallographic Studies (N. Choi & M. McPartlin). Mass Spectrometry and Gas Chromatography-Mass Spectrometry of Aminoalkanephosphonic Acids (Z. Kudzin & M. Sochaki). The Biological Activity of Phosphono- and Phosphinopeptides (P. Kafarski & B. Lejezak). Aminophosphonic and Aminophosphinic Acids and their Derivatives as Agrochemicals (H. Hudson). Neuroactive Aminophosphonic and Aminophosphinic Acid Derivatives (D. Jane). Aminophosphonic and Aminophosphinic Acid Derivatives in the Design of Transition State Analogue Inhibitors: Biomedical Opportunities and Limitations (J. Oleksyszyn). Aminophosphonic and Aminophosphinic Acids in the Design and Synthesis of HIV Protease Inhibitors (A. Peyman). Aminophosphonic Acid Derivatives as Antithrombotic Agents (D. Green, et al.). Aminophosphonic and Aminophosphinic Acid Derivatives as Inhibitors of Human Collagenase (R. Markwell). Index.
Rezensionen
"...will be useful for introducing new workers to these fields, as well as occupying an important place on many reference bookshelves." -- Applied Organometallic Chemistry, Vol 14, 2000
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