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Written by well-known experts in field, this is the first book dedicated to dealing with the single most challenging management issue in long-term steroid therapy. Overcoming Steroid Insensitivity in Respiratory Disease reviews important new advances in therapeutics and provides the clinician with the most up to date information on one of the most significant therapeutic challenges to effective management of these diseases. This unique book is an invaluable resource for all postgraduate students and specialist physicians in pulmonology allergy and asthma. It is also of interest for workers in biomedical and pharmaceutical research.…mehr
Written by well-known experts in field, this is the first book dedicated to dealing with the single most challenging management issue in long-term steroid therapy. Overcoming Steroid Insensitivity in Respiratory Disease reviews important new advances in therapeutics and provides the clinician with the most up to date information on one of the most significant therapeutic challenges to effective management of these diseases. This unique book is an invaluable resource for all postgraduate students and specialist physicians in pulmonology allergy and asthma. It is also of interest for workers in biomedical and pharmaceutical research.
Ian Adcock, Professor of Respiratory Cell and Molecular Biology at the National Heart and Lung Institute, Royal Brompton Campus,?London, UK. K Fan Chung, Professor, Experimental Studies Group, NHLI, Royal Brompton Campus,?London, UK.
Inhaltsangabe
Contents List of contributors Preface 1 Molecular Mechanisms of Glucocorticoid Receptor Action Pankaj Bhavsar and Ian M. Adcock 2 Side Effects of Topical and Oral Glucocorticoids Heike Schäcke, Khusru Asadullah and Wolf-Dietrich Döcke 3 Glucocorticoid Receptor Subtypes and Steroid Sensitivity Robert H. Oakley and John A. Cidlowski 4 Dissociated Glucocorticoids Ian M. Adcock 5 Generalized Glucocorticoid Insensitivity: Clinical Phenotype and Molecular Mechanisms Evangelia Charmandari, Tomoshige Kino and George P. Chrousos 6 Corticosteroid Responsiveness in Asthma: Clinical Aspects Kian Fan Chung 7 Glucocorticoid-insensitive Asthma: Molecular Mechanisms John W. Bloom 8 Cigarette Smoke, Oxidative Stress and Corticosteroid Responsiveness Irfan Rahman and David Adenuga 9 Regulation of Glucocorticoid Sensitivity by Macrophage Migration Inhibitory Factor Eric F. Morand 10 Steroid-sparing Strategies: Long-acting Inhaled ²2 -Agonists Anna Miller-Larsson and Olof Selroos 11 Steroid-sparing Strategies: Other Combinations Gaetano Caramori, Kazuhiro Ito and Alberto Papi 12 Kinases as Anti-inflammatory Targets for Respiratory Disease Iain Kilty 13 Pharmacokinetic/Pharmacodynamic Factors and Steroid Sensitivity Gönther Hochhaus 14 Improved Lung Deposition: New Inhaler Devices Omar S. Usmani Index
Contents List of contributors Preface 1 Molecular Mechanisms of Glucocorticoid Receptor Action Pankaj Bhavsar and Ian M. Adcock 2 Side Effects of Topical and Oral Glucocorticoids Heike Schäcke, Khusru Asadullah and Wolf-Dietrich Döcke 3 Glucocorticoid Receptor Subtypes and Steroid Sensitivity Robert H. Oakley and John A. Cidlowski 4 Dissociated Glucocorticoids Ian M. Adcock 5 Generalized Glucocorticoid Insensitivity: Clinical Phenotype and Molecular Mechanisms Evangelia Charmandari, Tomoshige Kino and George P. Chrousos 6 Corticosteroid Responsiveness in Asthma: Clinical Aspects Kian Fan Chung 7 Glucocorticoid-insensitive Asthma: Molecular Mechanisms John W. Bloom 8 Cigarette Smoke, Oxidative Stress and Corticosteroid Responsiveness Irfan Rahman and David Adenuga 9 Regulation of Glucocorticoid Sensitivity by Macrophage Migration Inhibitory Factor Eric F. Morand 10 Steroid-sparing Strategies: Long-acting Inhaled ²2 -Agonists Anna Miller-Larsson and Olof Selroos 11 Steroid-sparing Strategies: Other Combinations Gaetano Caramori, Kazuhiro Ito and Alberto Papi 12 Kinases as Anti-inflammatory Targets for Respiratory Disease Iain Kilty 13 Pharmacokinetic/Pharmacodynamic Factors and Steroid Sensitivity Gönther Hochhaus 14 Improved Lung Deposition: New Inhaler Devices Omar S. Usmani Index
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