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Cancer Stem Cells covers a wide range of topics in cancer stem cell biology, including the functional characteristics of cancer stem cells and how they're generated, where they are localized, the means by which cancer stem cells can be targeted, and how cancer stem cells can be reprogrammed back to normal tissue stem cells. Each chapter begins with a brief historical note and concept summary, followed by a description of the latest basic or clinical advance associated with the topic. Cancer Stem Cells builds systematically from coverage of the basic research stage to an advanced research…mehr
Cancer Stem Cells covers a wide range of topics in cancer stem cell biology, including the functional characteristics of cancer stem cells and how they're generated, where they are localized, the means by which cancer stem cells can be targeted, and how cancer stem cells can be reprogrammed back to normal tissue stem cells. Each chapter begins with a brief historical note and concept summary, followed by a description of the latest basic or clinical advance associated with the topic. Cancer Stem Cells builds systematically from coverage of the basic research stage to an advanced research level, from clinical relevance to therapeutic potential, and will be a valuable resource for professionals in the fields of cancer research and stem cell biology.
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Dr. V.K. Rajasekhar, M.Sc., M.Phil., Ph.D., is a Senior Research Scientist at Memorial Sloan-Kettering Cancer Center, New York. His work with patient derived prostate cancer stem cell xenografts, a first study in renewable Biobanking of these clinically relevant cells, has garnered eclectic post-publication reviews. Dr. Rajasekhar has received competitive research awards from the Alexander von Humboldt Foundation, Germany, and the Robert A. Welch Foundation, Texas. He has conducted research at MD Anderson Cancer Center in Houston, University of California at Irvine, University of Freiburg in Germany, etc., and taught at the University of California, Irvine and the University of Medicine and Dentistry of New Jersey. Dr. Rajasekhar has served as a peer reviewer for several journals, including Stem Cells, Proceedings of National Academy of Sciences USA, Journal of Molecular Biology, Journal of Cell Biology, Neoplasia, etc.
Inhaltsangabe
About the Editor xi Contributors xiii Foreword xxi Preface xxiii Acknowledgments xxxv Section I Essentials of Cancer Stem Cells and Conceptual Modeling 1 1 Theoretical and Experimental Foundations of the "Cancer Stem Cell" Model 3 Pradeep S. Rajendran and Piero Dalerba 2 The Hallmarks of Prostate Cancer Stem Cells 17 Norman J. Maitland and Anne T. Collins 3 Self-Renewal, Induced Proliferation, and Autonomous Cell Growth Represent Distinct Modes of Cell Multiplication: Relevance to the Cancer Stem Cell Theory 39 Dov Zipori 4 Human Embryonic Stem Cells and Cancer: Modeling Disease in a Dish 49 Tamra Werbowetski-Ogilvie and Robyn McClelland 5 Cancer Stem Cell as a Result of a Reprogramming-Like Mechanism: Implications in Tumor Development and Treatment 61 J.M. Iglesias, Idoia Garcia-Ramirez, Alberto Martin-Lorenzo, L. Vellon, Lucia Ruiz-Roca, A.G. Martin, and Isidro Sanchez-Garcia 6 A Cancer Stem Cell Model: An Insight into the Conversion of Induced Pluripotent Stem Cells to Cancer Stem-Like Cells 79 Akifumi Mizutani, Ling Chen, Tomonari Kasai, Takayuki Kudoh, Hiroshi Murakami, Li Fu, and Masaharu Seno 7 Altruistic Stem Cells and Cancer Stem Cells 89 Bikul Das 8 The Emerging Concept of EMT-Induced Cancer Stem Cells 107 Jeremy Bastid 9 Models to Study Chronic Myeloid Leukemia Cancer Stem Cells 119 Sheela A. Abraham, Lisa Hopcroft, Ravi Bhatia, Steffen Koschmieder, Anthony D. Whetton, and Tessa L. Holyoake 10 Cancer Stem Cells in Melanoma: Biomarkers and Mathematical Models 133 Stefano Zapperi and Caterina A.M. La Porta Section II Stem Cells in Liquid Tumors 143 11 Acute Myeloid Leukemia Stem Cells--Updates and Controversies 145 Stephen S. Chung and Christopher Y. Park 12 Leukemia-Initiating Cells in Acute Lymphoblastic Leukemia 161 Thorsten Raff and Monika Brüggemann Section III Stem Cells in Solid Tumors 171 13 Lung Cancer Stem Cells and Resistance to Radiotherapy 173 Scott V. Bratman and Maximilian Diehn 14 Prostate Cancer Cell Heterogeneity and Prostate Cancer Stem Cells 183 Mark A. Badeaux and Dean G. Tang 15 Glioblastoma Stem Cells Drive Tumor Recurrence and Patient Relapse: What's the Evidence? 193 Aneet Mann, Randy van Ommeren, Branavan Manoranjan, Nicole McFarlane, Parvez Vora, Chitra Venugopal, and Sheila Singh 16 Stem Cells and Pancreatic Cancer 209 Susana Garcia-Silva and Christopher Heeschen 17 Melanoma Subpopulations with Cancer Stem Cell Phenotypes 223 Rajasekharan Somasundaram, Nicole Facompre, and Meenhard Herlyn 18 Sarcoma Stem Cells 235 Filemon S. Dela Cruz and Igor Matushansky Section IV Cancer Stem Cells in Tumor Metastasis Perspective 247 19 Cancer Stem Cells in Metastasis and Minimal Residual Disease 249 Joerg Huelsken and Albert Santamaria i Martinez 20 Role of Cancer Stem Cells in Metastasis 259 Giovanna Merchand-Reyes, Rosana Pelayo, Lenin Pavón, Richard G. Pestell, and Marco Velasco-Velázquez 21 Cancer Stem Cells and the Stromal Microenvironment 273 Li Li and David A. Margolin 22 A Perspective on Breast Cancer Malignant Progression: From Cancer Stem Cell Intra Tumor Heterogeneity to Metastasis-Initiating Cells 287 Pasquale Sansone, Vinagolu K. Rajasekhar, and Jacqueline Bromberg Section V Novel and Potential Targets in Cancer Stem Cells 295 23 Targeting Cancer Stem Cells--Modulating Embryonic Stem Cell Signaling, Epigenetics, and Tumor Metabolism 297 Naoko Takebe, Pamela Jo Harris, Yutaka Kondo, Abhilasha Nair, S. Percy Ivy, and Hideyuki Saya 24 Oct4, Oct1, and Cancer Stem Cells 319 Jessica Maddox and Dean Tantin 25 The Role of Cripto-1 in Cancer and Cancer Stem Cells 331 Hideaki Karasawa, Nadia P. Castro, Maria Cristina Rangel, and David S. Salomon 26 Leptin Signaling in the Regulation of Stem and Cancer Stem Cells 347 Shanchun Guo, Keshav K. Singh, James W. Lillard, and Lily Yang 27 Tumor-Initiating Stem-Like Cells: Carcinogenesis through Toll-Like Receptors, Environmental Factors, and Virus 361 Keigo Machida 28 The Role of Epithelial Cell Polarity Pathways on Cancer Stem Cells 373 Inmaculada Banon-Rodriguez, Ilenia Bernascone, and Fernando Martin-Belmonte 29 Cancer-Initiating Cells, Exosomes, and the Premetastatic Niche 389 Margot Zöller 30 MicroRNA Therapeutics to Target Brain Tumor Stem Cells 403 Derryn Xin Hui Chan, Srikanth Nama, Gopinath Sundaram, and Prabha Sampath 31 The Riboproteome Orchestrates Self-Renewal and Cell Fate in Leukemia 417 Elianna M. Amin and Michael G. Kharas Section VI Clinical Relevance of Cancer Stem Cells in Patients 435 32 Targeting Different States of Breast Cancer Stem Cells 437 Sean P. McDermott and Max S. Wicha 33 Difficulties in Targeting the Beating Heart: Therapeutic Implications of the Cancer Stem Cell Hypothesis in Melanoma 451 Jennifer Makalowski and Hinrich Abken 34 Targeting Cancer Stem Cells for Overcoming Drug Resistance and Cancer Progression 461 Yiwei Li, Dejuan Kong, Aamir Ahmad, Bin Bao, and Fazlul H. Sarkar 35 The Role of Cancer Stem Cells in Tumor Radioresistance 473 I. Kurth, C. Peitzsch, M. Baumann, and A. Dubrovska Index 493 Color plate located between pages 222 and 223.
About the Editor xi Contributors xiii Foreword xxi Preface xxiii Acknowledgments xxxv Section I Essentials of Cancer Stem Cells and Conceptual Modeling 1 1 Theoretical and Experimental Foundations of the "Cancer Stem Cell" Model 3 Pradeep S. Rajendran and Piero Dalerba 2 The Hallmarks of Prostate Cancer Stem Cells 17 Norman J. Maitland and Anne T. Collins 3 Self-Renewal, Induced Proliferation, and Autonomous Cell Growth Represent Distinct Modes of Cell Multiplication: Relevance to the Cancer Stem Cell Theory 39 Dov Zipori 4 Human Embryonic Stem Cells and Cancer: Modeling Disease in a Dish 49 Tamra Werbowetski-Ogilvie and Robyn McClelland 5 Cancer Stem Cell as a Result of a Reprogramming-Like Mechanism: Implications in Tumor Development and Treatment 61 J.M. Iglesias, Idoia Garcia-Ramirez, Alberto Martin-Lorenzo, L. Vellon, Lucia Ruiz-Roca, A.G. Martin, and Isidro Sanchez-Garcia 6 A Cancer Stem Cell Model: An Insight into the Conversion of Induced Pluripotent Stem Cells to Cancer Stem-Like Cells 79 Akifumi Mizutani, Ling Chen, Tomonari Kasai, Takayuki Kudoh, Hiroshi Murakami, Li Fu, and Masaharu Seno 7 Altruistic Stem Cells and Cancer Stem Cells 89 Bikul Das 8 The Emerging Concept of EMT-Induced Cancer Stem Cells 107 Jeremy Bastid 9 Models to Study Chronic Myeloid Leukemia Cancer Stem Cells 119 Sheela A. Abraham, Lisa Hopcroft, Ravi Bhatia, Steffen Koschmieder, Anthony D. Whetton, and Tessa L. Holyoake 10 Cancer Stem Cells in Melanoma: Biomarkers and Mathematical Models 133 Stefano Zapperi and Caterina A.M. La Porta Section II Stem Cells in Liquid Tumors 143 11 Acute Myeloid Leukemia Stem Cells--Updates and Controversies 145 Stephen S. Chung and Christopher Y. Park 12 Leukemia-Initiating Cells in Acute Lymphoblastic Leukemia 161 Thorsten Raff and Monika Brüggemann Section III Stem Cells in Solid Tumors 171 13 Lung Cancer Stem Cells and Resistance to Radiotherapy 173 Scott V. Bratman and Maximilian Diehn 14 Prostate Cancer Cell Heterogeneity and Prostate Cancer Stem Cells 183 Mark A. Badeaux and Dean G. Tang 15 Glioblastoma Stem Cells Drive Tumor Recurrence and Patient Relapse: What's the Evidence? 193 Aneet Mann, Randy van Ommeren, Branavan Manoranjan, Nicole McFarlane, Parvez Vora, Chitra Venugopal, and Sheila Singh 16 Stem Cells and Pancreatic Cancer 209 Susana Garcia-Silva and Christopher Heeschen 17 Melanoma Subpopulations with Cancer Stem Cell Phenotypes 223 Rajasekharan Somasundaram, Nicole Facompre, and Meenhard Herlyn 18 Sarcoma Stem Cells 235 Filemon S. Dela Cruz and Igor Matushansky Section IV Cancer Stem Cells in Tumor Metastasis Perspective 247 19 Cancer Stem Cells in Metastasis and Minimal Residual Disease 249 Joerg Huelsken and Albert Santamaria i Martinez 20 Role of Cancer Stem Cells in Metastasis 259 Giovanna Merchand-Reyes, Rosana Pelayo, Lenin Pavón, Richard G. Pestell, and Marco Velasco-Velázquez 21 Cancer Stem Cells and the Stromal Microenvironment 273 Li Li and David A. Margolin 22 A Perspective on Breast Cancer Malignant Progression: From Cancer Stem Cell Intra Tumor Heterogeneity to Metastasis-Initiating Cells 287 Pasquale Sansone, Vinagolu K. Rajasekhar, and Jacqueline Bromberg Section V Novel and Potential Targets in Cancer Stem Cells 295 23 Targeting Cancer Stem Cells--Modulating Embryonic Stem Cell Signaling, Epigenetics, and Tumor Metabolism 297 Naoko Takebe, Pamela Jo Harris, Yutaka Kondo, Abhilasha Nair, S. Percy Ivy, and Hideyuki Saya 24 Oct4, Oct1, and Cancer Stem Cells 319 Jessica Maddox and Dean Tantin 25 The Role of Cripto-1 in Cancer and Cancer Stem Cells 331 Hideaki Karasawa, Nadia P. Castro, Maria Cristina Rangel, and David S. Salomon 26 Leptin Signaling in the Regulation of Stem and Cancer Stem Cells 347 Shanchun Guo, Keshav K. Singh, James W. Lillard, and Lily Yang 27 Tumor-Initiating Stem-Like Cells: Carcinogenesis through Toll-Like Receptors, Environmental Factors, and Virus 361 Keigo Machida 28 The Role of Epithelial Cell Polarity Pathways on Cancer Stem Cells 373 Inmaculada Banon-Rodriguez, Ilenia Bernascone, and Fernando Martin-Belmonte 29 Cancer-Initiating Cells, Exosomes, and the Premetastatic Niche 389 Margot Zöller 30 MicroRNA Therapeutics to Target Brain Tumor Stem Cells 403 Derryn Xin Hui Chan, Srikanth Nama, Gopinath Sundaram, and Prabha Sampath 31 The Riboproteome Orchestrates Self-Renewal and Cell Fate in Leukemia 417 Elianna M. Amin and Michael G. Kharas Section VI Clinical Relevance of Cancer Stem Cells in Patients 435 32 Targeting Different States of Breast Cancer Stem Cells 437 Sean P. McDermott and Max S. Wicha 33 Difficulties in Targeting the Beating Heart: Therapeutic Implications of the Cancer Stem Cell Hypothesis in Melanoma 451 Jennifer Makalowski and Hinrich Abken 34 Targeting Cancer Stem Cells for Overcoming Drug Resistance and Cancer Progression 461 Yiwei Li, Dejuan Kong, Aamir Ahmad, Bin Bao, and Fazlul H. Sarkar 35 The Role of Cancer Stem Cells in Tumor Radioresistance 473 I. Kurth, C. Peitzsch, M. Baumann, and A. Dubrovska Index 493 Color plate located between pages 222 and 223.
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