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The potential lipotoxic effect of accumulation of fatty acids innon-adipose tissues is thought to be a major component in thedevelopment of insulin resistance. Chronic exposure to highconcentrations of free fatty acids in the blood affects pancreaticbeta cell function, insulin secretion and lipid synthesis in theliver, and storage in adipose tissue. Maintaining the normal levelsof fatty acids requires coordinated regulation between the liver,adipose tissue and skeletal muscle. This book deals with the molecular aspects of fatty acid actionin obesity and insulin resistance. The topics include…mehr

Produktbeschreibung
The potential lipotoxic effect of accumulation of fatty acids innon-adipose tissues is thought to be a major component in thedevelopment of insulin resistance. Chronic exposure to highconcentrations of free fatty acids in the blood affects pancreaticbeta cell function, insulin secretion and lipid synthesis in theliver, and storage in adipose tissue. Maintaining the normal levelsof fatty acids requires coordinated regulation between the liver,adipose tissue and skeletal muscle. This book deals with the molecular aspects of fatty acid actionin obesity and insulin resistance. The topics include lipidmetabolism and adipose tissue biology, and beta cell function andinsulin resistance. Chapters deal with the molecular genetics andmolecular physiology of energy homeostasis.

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  • Produktdetails
  • Verlag: John Wiley & Sons
  • Seitenzahl: 222
  • Erscheinungstermin: 02.08.2008
  • Englisch
  • ISBN-13: 9780470985564
  • Artikelnr.: 37301141
Inhaltsangabe
Bruce M. Spiegelman Chair's introduction

Bruce M. Spiegelman
Transcriptional control of energy homeostasis through the PGC1 coactivators
Discussion

Stephen O'Rahilly
Human obesity and insulin resistance: lessons from xperiments of nature
Discussion

Deborah M. Muoio and Timothy R. Koves
Lipid-induced metabolic ysfunction in skeletal muscle
Discussion

Alan D. Attie, Matthew T. Flowers, Jessica B. Flowers, Albert K. Groen, Folkert Kuipers and James M. Ntambi
Stearoyl-CoA desaturase eficiency, hypercholesterolaemia, cholestasis and diabetes
Discussion

Karen Reue
The role of lipin 1 in adipogenesis and lipid metabolism
Discussion

David Carling
The role of the AMP-activated protein kinase in the regulation f energy homeostasis
Discussion

Gökhan S. Hotamisligil
Endoplasmic reticulum stress and inflammation in besity and type 2 diabetes
Discussion

Ira Tabas, Tracie Seimon, Jerry Arellano, Yankun Li, Fabien Forcheron, Dongying Cui, Seongah Han, Chien-Ping Liang, Alan Tall and Domenico Accili
The impact of insulin resistance on macrophage death athways in advanced atherosclerosis
Discussion

Sandra Lobo and David A. Bernlohr
Fatty acid transport in adipocytes and he development of insulin resistance
Discussion

Paul N. Black and Concetta C. DiRusso
Vectorial acylation: linking fatty cid transport and activation to metabolic trafficking
Discussion

Günther Daum, Andrea Wagner, Tibor Czabany, Karlheinz Grillitsch and Karin Athenstaedt
Lipid storage and mobilization pathways in yeast
Discussion

John Zhong Li and Peng Li
Cide proteins and the development of besity
Discussion

General discussion I
Visualizing brown adipose tissue with FDG-PET

Takashi Kadowaki, Toshimasa Yamauchi, Naoto Kubota, Kazuo Hara and Kohjiro Ueki
Adiponectin and adiponectin receptors in obesity-linked nsulin resistance
Discussion

Gabriel Pascual, Amy L. Sullivan, Sumito Ogawa, Amir Gamliel, Valentina Perissi, Michael G. Rosenfeld and Christopher K. Glass
Anti-inflammatory and antidiabetic roles of PPAR³
Discussion

Final discussion
Nutrition, ageing and lipotoxicity
Index of contributors

Subject index
Rezensionen
"This book will be an excellent resource for either beginning students or more established investigators in the field. The speakers are all top notch researchers who gave clear and informative presentations. The integrative nature of the follow up discussions and the excellent insights provided by the chair of the meeting throughout give the book an unusual coherence and consistency that is often lacking in broad, general reviews." ( Doody s , April 2008)