1. Short Introduction and History
Robert B. Raffa
Abstract
Introduction and History
Conclusion
2. Patient's Perspective
Robert B. Raffa and Kathy Martin
Abstract
Introduction
Conclusion
3. Oncology Nurse's Perspective
Jamie S. Myers
Abstract
Prelude: Personal Reflections of an Oncology Nurse
Chemotherapy?Related Cognitive Impairment: The Oncology Nurse Perspective
Oncology Nursing Research
Oncology Nursing Education
Conclusion
4. Oncology Pharmacist's Perspective
Rachel Clark?Vetri
Abstract
Introduction
Conclusion
5. The Impact of Chemo Brain on the Patient with a High Grade Glioma
Michele R. Lucas
Abstract
Background
Brain Cancer
Impact of Chemo Brain on the Patient
Impact of Chemo Brain on the Family
Impact of Chemo Brain on Society
Conclusion
6. Neurocognitive Efects of Childhood Cancer
Treatment
Jennifer Costa
Abstract
Background
Identified Risk Factors
Treatment of Childhood Leukemia: Past and Present
Treatment of Childhood Brain Tumors: Past and Present
Neurocognitive Effects of Chemotherapy
Cognitive Remediation
Pharmacological Intervention: Methylphenidate
Conclusion
7. The Economic Burden
Albert I. Wertheimer
Abstract
Epidemiology of Chemo Fog
Disease Impact
Economic Burden of Chemo Fog
Conclusion
8. Designing Conceptual Model?Based Research in Chemotherapy?Related Changes in Cognitive Function
Lisa M. Hess
Abstract Understanding the Issue
Designing Research Trials
Conclusion
9. Neuropsychologic Testing for Chemotherapy?Related Cognitive Impairment
Jamie S. Myers
Abstract
Introduction
Neuropsychologic Test Overview
Issues Related to Neurocognitive Testing for CRCI
Conclusion
10. Imaging as a Means of Studying Chemotherapy?Related Cognitive Impairment
Robert B. Raffa
Abstract
Introduction
Electrophysiological Studies
Neuroimaging Studies
Conclusion
11. Chemotherapy Associated Central Nervous System Damage
Jörg Dietrich
Abstract
Introduction
Stem Cells, Progenitor Cells and Lineage Systems within the Central
NervousSystem
Cell?Biological Analysis of Chemotherapy Associated Brain Damage
Conclusion
12. Is Systemic Anti?Cancer Therapy Neurotoxic? Does Chemo Brain Exist? And Should We Rename It?
Sophie Taillibert
Abstract
Introduction
Towards a Better Definition of Chemo Brain
Towards a Better Understanding of Chemo Brain
Does Chemo Brain Exist?
Conclusion
13. Evaluation of Multiple Neurotoxic Outcomes in Cancer Chemotherapy
Bernard Weiss
Abstract
Introduction
Two Contrasting Views of Neurotoxicity
Dimensions of Neurotoxicity
Lessons Learned from Studies of Cognitive Dysfunction
Cognitive Function Approaches
Sensory Function
Motor Function
Animal Models
Alternative Approaches
Conclusion
14. Chemotherapy?Related Visual System Toxicity
Robert B. Raffa
Abstract
Introduction
Visual?System Deficits in Chemo Fog/'Chemo Brain'
Chemotherapeutic Agent Toxicity on the Visual System
Conclusion
15. The Possible Role of Cytokines in Chemotherapy?Induced Cognitive Deficits
Jamie S. Myers
Abstract
The Role of Proinflammatory Cytokines
Overview of Cytokines
The Immune Response
Proinflammatory Cytokines and Cancer
Proinflammatory Cytokines and Antineoplastic Agents
Proinflammatory Cytokines and Sickness Behavior
Proinflammatory Cytokines and Other Symptoms
Future Implications
Conclusion
16. Pharmacokinetics of Anti?Cancer Drugs Used in Breast Cancer Chemotherapy
Swati Nagar
Abstract
Introduction
Pharmacokinetics of Anticancer Drugs Used in Breast Cancer Chemotherapy
Pharmacokinetics in Special Populations: Age and Menopause Status
Pharmacokinetics of Anticancer Drugs and Memory Deficit as a Pharmacodynamic Endpoint
Conclusion
17. Combination Analysis
Ronald J. Tallarida
Abstract
Introduction
Drug Additivity
Tests of Drug Combinations and the Isobole
Error Estimates
Dose?Effect Relation of the Drug Combination
Variable Potency Ratio
Conclusion
18. Animal Models
Ellen A. Walker
Abstract
Introduction
Effects of Cancer Chemotherapeutic Agents on the Disruption of Sensory
Processing