David Bensimon, Vincent Croquette, Jean-Francois Allemand, Xavier Michalet, Terence Strick

Single-Molecule Studies of Nucleic Acids and Their Proteins

• Gebundenes Buch

Produktbeschreibung

This book is an introduction to the novel physical tools that allow single molecule manipulation and visualisation. It describes the use of these tools to understand the elastic properties of single molecules of DNA and RNA and to study their interactions with the many proteins that process them.

Produktdetails

• Verlag: Oxford University Press, USA
• Seitenzahl: 240
• Erscheinungstermin: 20. Februar 2019
• Englisch
• Abmessung: 249mm x 175mm x 18mm
• Gewicht: 386g
• ISBN-13: 9780198530923
• ISBN-10: 0198530927
• Artikelnr.: 51966892

Autorenporträt

David Bensimon and Vincent Croquette have been co-leaders of a group at the LPS-ENS that has been studying single DNA molecules and their interactions with proteins since 1991. Jean-François Allemand, Terence Strick and Xavier Michalet have been their students and collaborators ever since. They have jointly developed magnetic traps and have been studying various aspects of single molecule DNA/protein transactions. Since joining the lab of Professor S. Weiss at UCLA , Xavier Michalet has been focusing on the use of fluorescent and spectroscopic methods to study single biomolecules.

Inhaltsangabe

1: Introduction to DNA
2: Manipulating DNA
3: Fluorescence Spectroscopy and Microscopy Techniques
4: The Mechanical Properties of Nucleic Acids
5: Structural Transitions in DNA
6: Single Molecule Studies of DNA-associated Motors
7: DNA and RNA Polymerases
8: DNA Helicases
9: Topoisomerases
10: Conclusions